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Clomipramine

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Identification
Molecular formula
C19H23ClN2
CAS number
303-49-1
IUPAC name
3-(2-chloro-6,11-dihydrobenzo[c][1]benzothiepin-11-yl)-N,N-dimethyl-propan-1-amine
State
State

Clomipramine exists as a solid at room temperature, typically in the form of its hydrochloride salt for pharmaceutical formulations.

Melting point (Celsius)
179.60
Melting point (Kelvin)
452.75
Boiling point (Celsius)
518.40
Boiling point (Kelvin)
791.55
General information
Molecular weight
314.87g/mol
Molar mass
314.8770g/mol
Density
1.2800g/cm3
Appearence

Clomipramine is typically a white to off-white crystalline powder. It might have negligible odor and is often available in the form of hydrochloride salt for its pharmaceutical preparations.

Comment on solubility

Solubility of 3-(2-chloro-6,11-dihydrobenzo[c][1]benzothiepin-11-yl)-N,N-dimethyl-propan-1-amine

The solubility of 3-(2-chloro-6,11-dihydrobenzo[c][1]benzothiepin-11-yl)-N,N-dimethyl-propan-1-amine is influenced by its structural characteristics and functional groups. Key factors affecting its solubility include:

  • Molecular Weight: The relatively high molecular weight can lead to decreased solubility in water.
  • Polarity: The presence of chlorine atoms and other substituents may alter the compound's overall polarity.
  • Hydrogen Bonding: The potential for hydrogen bonding may enhance solubility in polar solvents.

In general, compounds such as this one, which possess an aromatic system combined with aliphatic amines, may exhibit:

  • Moderate solubility in organic solvents, including ethanol and dichloromethane.
  • Limited solubility in water, depending on the pH and temperature conditions.

It is often observed that larger substituents or bulky groups can significantly hinder solubility in aqueous environments. In practical applications, exploring various solvents and conditions is essential to determine the optimal solubility for this compound, as the solubility profile might vary substantially based on experimental setups.

Interesting facts

Interesting Facts about 3-(2-Chloro-6,11-dihydrobenzo[c][1]benzothiepin-11-yl)-N,N-dimethyl-propan-1-amine

This unique compound boasts intriguing characteristics that catch the interest of chemists and pharmacologists alike. Here are some remarkable aspects surrounding this compound:

  • Complex Structure: The chemical structure of this compound is quite intricate, featuring a fused bicyclic system. The presence of the benzothiepin moiety adds a layer of complexity that can lead to unique pharmacological properties.
  • Pharmacological Potential: Compounds with similar structures have drawn attention for their potential use as therapeutic agents. They may interact with various biological targets, which can lead to various medicinal properties.
  • Substituents Matter: The inclusion of the 2-chloro substitution introduces halogen chemistry into the compound, which can significantly influence how it interacts within biological systems. Halogens often affect the lipophilicity and biological activity.
  • Applications in Research: Due to its unique features, this compound is likely to be of interest in medicinal chemistry and drug discovery. Researchers may explore its effects on neurotransmitter systems, particularly in relation to neuropsychiatric disorders.
  • Analytical Challenges: The complexity of this molecule presents analytical challenges in terms of purification and characterization. Techniques like NMR, mass spectrometry, and chromatography are essential in accurately determining its properties and behavior.

In conclusion, 3-(2-chloro-6,11-dihydrobenzo[c][1]benzothiepin-11-yl)-N,N-dimethyl-propan-1-amine exemplifies the exciting intersection of structure and biological activity in chemical research. Its potential uses and implications in pharmacology make it a fascinating subject for ongoing studies.