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Clomipramine hydrochloride

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Identification
Molecular formula
C19H23ClN2S
HCl
CAS number
303-49-1
IUPAC name
3-(2-chloro-6,11-dihydrobenzo[c][1]benzothiepin-11-yl)propyl-dimethyl-ammonium;chloride
State
State

Clomipramine hydrochloride is typically in a solid state at room temperature. It exists as a crystalline powder that is hygroscopic, meaning it can absorb moisture from the air.

Melting point (Celsius)
191.30
Melting point (Kelvin)
464.45
Boiling point (Celsius)
265.00
Boiling point (Kelvin)
538.15
General information
Molecular weight
351.30g/mol
Molar mass
351.3010g/mol
Density
1.1600g/cm3
Appearence

Clomipramine hydrochloride is generally found as a white or slightly yellow crystalline powder. It may appear slightly off-white if impurities are present.

Comment on solubility

Solubility of 3-(2-chloro-6,11-dihydrobenzo[c][1]benzothiepin-11-yl)propyl-dimethyl-ammonium chloride

The solubility of 3-(2-chloro-6,11-dihydrobenzo[c][1]benzothiepin-11-yl)propyl-dimethyl-ammonium chloride can be characterized as follows:

  • Nature of the Compound: Being a quaternary ammonium salt, its solubility tends to be high in polar solvents.
  • Solvent Interaction: This compound is likely to be soluble in water due to the presence of the chloride ion, which can interact favorably with water molecules.
  • Factors Affecting Solubility:
    • Temperature: Increased temperature generally enhances solubility for ionic compounds.
    • pH Level: The solubility might be influenced by the pH of the solution, possibly affecting ionization.
    • Presence of Other Ions: The solubility can also be altered by the presence of other ions in the solution, potentially leading to precipitation or complexation.
  • Practical Implications: Knowledge of this compound's solubility is essential for applications in biomedical fields, where the solubility can impact its bioavailability and pharmacokinetics.

In summary, while specific solubility data may vary, the characteristic properties of quaternary ammonium salts suggest that this compound will demonstrate appreciable solubility in polar environments, particularly water.

Interesting facts

Interesting Facts about 3-(2-chloro-6,11-dihydrobenzo[c][1]benzothiepin-11-yl)propyl-dimethyl-ammonium;chloride

This fascinating compound is a part of the class of chemicals known as quaternary ammonium compounds, which are known for their unique properties and various applications. Here are some intriguing points about this specific compound:

  • Pharmaceutical Significance: This compound is related to benzothiepin derivatives, which have shown potential in the development of new pharmaceutical agents, particularly for their neuroactive effects.
  • Chlorine Influence: The presence of a chlorine atom plays a crucial role in the compound's reactivity and biological activity, often enhancing efficacy in medicinal chemistry applications.
  • Ammonium Quaternary Structure: Its quaternary ammonium structure contributes to unique properties such as stability and the ability to interact with a variety of biological systems, making it useful in both drug design and as a surfactant.
  • Historical Context: Compounds of this nature have been explored extensively since the mid-20th century, providing a rich history of research in medicinal chemistry.

As a student or scientist, understanding such compounds opens the door to innovations in medicine and other industries. Embracing the complexity within a single compound is what makes chemistry truly exciting!

Synonyms
Dibenz(b,e)thiepin, 6,11-dihydro-2-chloro-11-(3-(dimethylamino)propyl)-, hydrochloride
2-Chloro-6,11-dihydro-11-(3-(dimethylamino)propyl)dibenz(b,e)thiepin hydrochloride
1159-84-8