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Loratadine

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Identification
Molecular formula
C22H23ClN2O
CAS number
79794-75-5
IUPAC name
3-[(2-chloro-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-yl)oxy]-N,N,2-trimethyl-propan-1-amine
State
State

At room temperature, loratadine is in a solid state.

Melting point (Celsius)
134.00
Melting point (Kelvin)
407.00
Boiling point (Celsius)
247.80
Boiling point (Kelvin)
520.95
General information
Molecular weight
382.89g/mol
Molar mass
382.8840g/mol
Density
1.1460g/cm3
Appearence

Loratadine is a white to off-white crystalline powder. It is practically insoluble in water but soluble in organic solvents such as ethanol, methanol, and acetone.

Comment on solubility

Solubility of 3-[(2-chloro-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-yl)oxy]-N,N,2-trimethyl-propan-1-amine

The solubility of 3-[(2-chloro-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-yl)oxy]-N,N,2-trimethyl-propan-1-amine can be influenced by several factors related to its molecular structure and functional groups.

Factors Affecting Solubility

  • Polarity: The presence of the amine group and the ether bond can contribute to the molecule's polarity, enhancing its ability to dissolve in polar solvents like water.
  • Hydrogen Bonding: The amine's capacity to participate in hydrogen bonding could further aid solubility, particularly in protic solvents.
  • Hydrophobic Regions: Conversely, the bulky cycloheptaquinoline structure may create hydrophobic regions, limiting solubility in polar solvents and favoring organic solvents instead.
  • Temperature: Solubility is often temperature-dependent; increased temperatures typically enhance the solubility of organic compounds.

In summary, while this compound may exhibit partial solubility in polar solvents due to its functional groups, its extensive hydrophobic regions suggest that it could be more soluble in nonpolar organic solvents. Therefore, understanding the solubility of this compound requires careful consideration of the solvent's characteristics as well as the compound's structural features.

Interesting facts

Interesting Facts about 3-[(2-chloro-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-yl)oxy]-N,N,2-trimethyl-propan-1-amine

This fascinating compound has attracted the attention of researchers due to its unique structural characteristics and potential applications in various fields. Here are some notable points to consider:

  • Complex Structure: The compound features a blend of a cycloheptaquinoline core and a trimethylamine moiety, showcasing an intricate interplay of aromatic and aliphatic features. This complexity allows for interesting physicochemical properties.
  • Biological Relevance: Compounds similar to this one have exhibited a range of biological activities, especially in medicinal chemistry. The quinoline scaffold is known for its *antimicrobial and antitumor effects*, which makes this compound a candidate for further bioactivity studies.
  • Potential Drug Development: Researchers often examine compounds with this type of structure for drug development, particularly in targeting diseases where traditional therapies have been ineffective. The presence of chlorine adds to its chemical diversity, which can influence its reactivity and interactions.
  • Insight into Structure-Activity Relationship (SAR): The detailed study of compounds like this contributes to a greater understanding of SAR, a pivotal aspect in drug design. Variations in substituents can drastically change biological activity, making them crucial for optimizing pharmacological profiles.
  • Interesting Reaction Pathways: Organic chemists may explore various synthetic routes to produce such compounds, potentially uncovering new reaction mechanisms or strategies for incorporating complex, multi-cyclic structures.

In summary, 3-[(2-chloro-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-yl)oxy]-N,N,2-trimethyl-propan-1-amine is not just a compound of interest because of its molecular structure, but also for its potential impact in the fields of pharmacology and material science. The ongoing research around compounds like this opens exciting avenues for discovery and innovation.