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Clotrimazole

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Identification
Molecular formula
C22H17ClN2O
CAS number
23593-75-1
IUPAC name
3-[(2-chloro-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-yl)sulfanyl]-N,N-dimethyl-propan-1-amine
State
State

At room temperature, clotrimazole is in a solid state. It is provided primarily in this form for direct application or for formulation into creams, lotions, or tablets for medicinal use. As such, it's a stable compound suitable for various pharmaceutical preparations.

Melting point (Celsius)
142.00
Melting point (Kelvin)
415.15
Boiling point (Celsius)
531.50
Boiling point (Kelvin)
804.65
General information
Molecular weight
344.85g/mol
Molar mass
344.8480g/mol
Density
1.2978g/cm3
Appearence

Clotrimazole appears as a white crystalline powder. It is odorless and is often noted for its crystalline structure. Used primarily in a medicinal context, specifically as an antifungal agent, its appearance as a powder is typical for many pharmaceutical compounds, making it easy to handle and use in formulations.

Comment on solubility

Solubility of 3-[(2-chloro-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-yl)sulfanyl]-N,N-dimethyl-propan-1-amine

The solubility of 3-[(2-chloro-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-yl)sulfanyl]-N,N-dimethyl-propan-1-amine is influenced by several factors, including its molecular structure and the presence of functional groups. Understanding the solubility of this compound is crucial for various applications in pharmaceuticals and chemical research.

Key Factors Affecting Solubility:

  • Polarity: The presence of polar functional groups can enhance solubility in polar solvents, while non-polar regions may favor solubility in non-polar solvents.
  • Hydrogen Bonding: Compounds capable of forming hydrogen bonds often exhibit improved solubility in water, which is vital for biological activity.
  • pH Dependence: The solubility of amines can change significantly with pH, as protonation can increase their solubility in aqueous environments.

In general, 3-[(2-chloro-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-yl)sulfanyl]-N,N-dimethyl-propan-1-amine is expected to show varying solubility properties across different solvents. Experimental data should be consulted for precise solubility values, but theoretical predictions suggest:

  • Possible moderate solubility in polar solvents.
  • Lower solubility in non-polar solvents due to its structural characteristics.

Experimentation and further research are essential to confirm these solubility trends and to fully understand the implications for its practical use.

Interesting facts

Interesting Facts about 3-[(2-chloro-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-yl)sulfanyl]-N,N-dimethyl-propan-1-amine

This complex organic compound is a fascinating example of medicinal chemistry, particularly in the development of novel therapeutic agents. Known for the intricate architecture of its molecular structure, it showcases a variety of chemical functionalities that provide valuable insights into drug design and synthesis.

Key Features of the Compound:

  • Chlorinated Compound: The presence of a chlorine atom introduces unique reactivity patterns and can influence the pharmacokinetic properties of the molecule.
  • Cyclohepta[b]quinoline Framework: This bicyclic moiety is notable for its biological activity, often associated with alkaloids and their derivatives, which have been used in various therapeutic areas.
  • Sulfanyl Group: The sulfanyl functional group is known for its ability to participate in various chemical reactions, potentially enhancing the bioactivity of the compound.
  • Dimethylamine Substituent: The N,N-dimethyl element contributes to the compound's basicity and can influence its interaction with biological targets, such as receptors or enzymes.

In the realm of pharmacology, compounds like this one are often investigated for:

  • Antimicrobial properties
  • Anticancer effects
  • Psychoactive potential

Moreover, the synthesis of such a compound might involve various advanced techniques in organic chemistry, including:

  • Multi-step synthesis pathways
  • Use of protecting groups
  • Rigorous purification methods

As an educational insight, it’s important to note that understanding the structure-activity relationship (SAR) of such compounds can lead to groundbreaking discoveries in the field of drug development. Characters of the compound serve as crucial building blocks in exploring how modifications affect overall biological activity.

In summary, 3-[(2-chloro-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-yl)sulfanyl]-N,N-dimethyl-propan-1-amine is not just a compound, but a gateway into the complex world of organic chemistry and pharmaceutical research, engaging scientists in the pursuit of new knowledge and innovative therapies.