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Amiodarone hydrochloride

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Identification
Molecular formula
C25H30Cl2N2O3
CAS number
19774-82-4
IUPAC name
3-[(2-chloro-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-5-ium-11-yl)amino]propyl-dimethyl-ammonium;dichloride
State
State

Amiodarone hydrochloride is typically found in a solid state at room temperature.

Melting point (Celsius)
158.00
Melting point (Kelvin)
431.15
Boiling point (Celsius)
379.50
Boiling point (Kelvin)
652.65
General information
Molecular weight
681.79g/mol
Molar mass
681.7860g/mol
Density
1.4000g/cm3
Appearence

Amiodarone hydrochloride appears as a white or yellow crystalline powder. It is slightly hygroscopic, meaning it can absorb moisture from the air. The crystalline structure forms well-defined edges and can appear slightly translucent when in small quantities.

Comment on solubility

Solubility of 3-[(2-chloro-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-5-ium-11-yl)amino]propyl-dimethyl-ammonium; dichloride

The solubility of the compound 3-[(2-chloro-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-5-ium-11-yl)amino]propyl-dimethyl-ammonium; dichloride can be influenced by several factors due to its complex ionic structure.

Key Factors Influencing Solubility:

  • Polarity: Given its quaternary ammonium structure, the compound is likely to possess significant polarity, enhancing its solubility in polar solvents, particularly water.
  • Ionic Interactions: The dichloride component suggests robust ionic interactions which may further promote solubility in aqueous solutions.
  • Temperature: Increased temperatures may augment the solubility of this compound, making it more soluble in various solvent systems.
  • pH Levels: The solubility can vary depending on the pH of the solution, as protonation states of the amino groups may change.

Interestingly, solubility can often dictate the bioavailability and functionality of compounds in biological systems. For this compound, understanding its solubility profile is critical for its applications in pharmaceuticals and related fields.

In conclusion, while specific solubility data may not be readily available, one can hypothesize that 3-[(2-chloro-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-5-ium-11-yl)amino]propyl-dimethyl-ammonium; dichloride should exhibit appreciable solubility in polar solvents, particularly in conditions that enhance ionic dissociation and interaction.

Interesting facts

Interesting Facts About 3-[(2-Chloro-7,8,9,10-tetrahydro-6H-cycloheptabquinolin-5-ium-11-yl)amino]propyl-dimethyl-ammonium; dichloride

This fascinating compound, often referred to in research due to its unique structure and properties, plays an intriguing role in the fields of medicinal chemistry and pharmacology.

Key Features:

  • Quinoline Derivative: The compound features a quinoline moiety, which is known for its diverse biological activities including anti-microbial and anti-cancer properties. Quinoline derivatives have been widely studied for their potential as therapeutic agents.
  • Cationic Nature: The presence of the dimethylammonium group makes this compound cationic, which can enhance its interaction with biomolecules and cell membranes, making it a candidate for drug delivery systems.
  • Chlorine Atom: The inclusion of a chlorine atom not only enhances lipophilicity but can also influence the compound's reactivity, potentially leading to various applications in organic synthesis.

Furthermore, researchers have explored this compound for its potential in:

  • Anticholinergic Effects: Its structural similarity to neurotransmitters makes it a subject of investigation for altering neuronal signaling pathways.
  • Aromatic Interactions: The cycloheptab quinoline system might facilitate unique interactions in biological systems, enhancing its effectiveness in therapeutic contexts.

In the realm of scientific exploration, this compound stands out due to its complex structure and diverse potential applications in drug development, showcasing the fusion of organic chemistry with biological relevance. As we delve deeper into research, its therapeutic promise continues to unfold, making it a compound of great interest in various fields!

Synonyms
18833-76-6
6H-Cyclohepta(b)quinoline, 2-chloro-11-((3-(dimethylamino)propyl)amino)-7,8,9,10-tetrahydro-, dihydrochloride