Skip to main content

Cetirizine hydrochloride

ADVERTISEMENT
Identification
Molecular formula
C21H27Cl3N2O3
CAS number
83881-52-1
IUPAC name
[3-[(2-chloro-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-5-ium-11-yl)oxy]-2-methyl-propyl]-dimethyl-ammonium;dichloride
State
State
Cetirizine hydrochloride is typically found in a solid state at room temperature in the form of tablets or capsules for oral administration.
Melting point (Celsius)
117.00
Melting point (Kelvin)
390.15
Boiling point (Celsius)
453.50
Boiling point (Kelvin)
726.70
General information
Molecular weight
461.82g/mol
Molar mass
461.8190g/mol
Density
1.0498g/cm3
Appearence
Cetirizine hydrochloride typically appears as a white to off-white, crystalline powder. It is relatively soluble in water, making it suitable for various pharmaceutical formulations.
Comment on solubility

Solubility of 3-[(2-chloro-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-5-ium-11-yl)oxy]-2-methyl-propyl]-dimethyl-ammonium;dichloride

The solubility of the compound 3-[(2-chloro-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-5-ium-11-yl)oxy]-2-methyl-propyl]-dimethyl-ammonium;dichloride is influenced by various factors such as its ionic nature and the presence of functional groups. Given its structure, we can anticipate several key points regarding its solubility:

  • Ionic Character: Being a quaternary ammonium salt, it is expected to have good solubility in polar solvents like water due to the ionic interactions.
  • Hydrophilicity: The presence of the dimethyl-ammonium group enhances solubility in aqueous solutions, making it more accessible for interactions with water molecules.
  • Polar Functional Groups: The chloro and oxy groups can further contribute to the hydrophilicity, positively influencing solubility.
  • Solvent Dependence: While it is likely soluble in water, its solubility in organic solvents could vary. For example, it may not exhibit the same level of solubility in non-polar solvents.

In summary, one might expect this compound to be relatively soluble in polar solvents while demonstrating limited solubility in non-polar solvents due to its ionic nature and functional groups that promote interactions with polar media.

Interesting facts

Interesting Facts about 3-[(2-chloro-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-5-ium-11-yl)oxy]-2-methyl-propyl]-dimethyl-ammonium;dichloride

This complex compound boasts a range of fascinating characteristics that make it a subject of interest in both chemical research and practical applications. Here are some compelling aspects:

  • Structural Diversity: The structure of this compound incorporates a unique fusion of a quinoline derivative and a dimethylammonium moiety. The presence of the cyclohepta[b]quinoline core contributes to its structural intrigue, potentially influencing its biological activity.
  • Biological Significance: Compounds like this can exhibit interesting pharmacological properties, which makes them valuable in medicinal chemistry. The ammonium group is often involved in interactions with biological targets, opening the door to potential therapeutic applications.
  • Charge Characteristics: The dichloride salt form indicates that the compound is positively charged, which may enhance its solubility in polar solvents and affect its behavior in biological systems. Charged species often have different transport mechanisms which can be crucial when considering drug design.
  • Chemical Reactivity: Due to the presence of both a chlorinated aromatic system and a quaternary ammonium group, this compound may undergo unique chemical reactions. These can include nucleophilic substitutions and interactions with other electrophiles in organic synthesis.
  • Potential Uses: There is speculation about the compound's uses in applications such as catalysis, dye production, or even as a starting material for synthesizing more complex molecules. Its dual functional groups suggest versatility across various fields of chemistry.

Notable points to consider in research involving this compound include its synthesis methods, reactivity under different conditions, and interactions with biological systems. As the field of chemistry evolves, compounds like this will undoubtedly continue to shine, inspiring innovation and exploration.

Synonyms
18833-57-3
6H-Cyclohepta(b)quinoline, 2-chloro-11-(3-(dimethylamino)-2-methylpropoxy)-7,8,9,10-tetrahydro-, dihydrochloride