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Chloroquine

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Identification
Molecular formula
C18H26Cl3N3O
CAS number
54-05-7
IUPAC name
3-[(2-chloro-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-5-ium-11-yl)oxy]propyl-dimethyl-ammonium;dichloride
State
State

At room temperature, Chloroquine is in a solid state. It is typically supplied as a crystalline powder for pharmaceutical applications.

Melting point (Celsius)
87.00
Melting point (Kelvin)
360.15
Boiling point (Celsius)
486.00
Boiling point (Kelvin)
759.15
General information
Molecular weight
515.87g/mol
Molar mass
515.8670g/mol
Density
1.3480g/cm3
Appearence

Chloroquine appears as a white to slightly yellow, crystalline powder when pure. It is odorless and has a bitter taste. The powder is very hygroscopic and tends to absorb moisture readily from the atmosphere, leading to clumping if not stored properly.

Comment on solubility

Solubility of 3-[(2-chloro-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-5-ium-11-yl)oxy]propyl-dimethyl-ammonium; dichloride

The solubility of 3-[(2-chloro-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-5-ium-11-yl)oxy]propyl-dimethyl-ammonium; dichloride can be influenced by several factors. This compound, being a quaternary ammonium salt, generally displays good solubility characteristics in various solvents.

Key Factors Affecting Solubility:

  • Polarity: The presence of polar functional groups often enhances solubility in polar solvents such as water.
  • Temperature: Higher temperatures can increase solubility for many salts, possibly due to the increased kinetic energy overcoming lattice forces.
  • pH Level: The ionic nature of the compound may be affected by pH, impacting its solubility in aqueous solutions.

Typically, quaternary ammonium salts are known for their ability to dissolve well in water due to their ionic nature. However, the specific structural features of the 3-[(2-chloro-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-5-ium-11-yl)oxy]propyl-dimethyl-ammonium part can introduce unique solubility characteristics, leading to potential solubility issues in organic solvents.

In summary, while this compound may be soluble in polar solvents, its solubility profile should be thoroughly characterized under varying conditions to ascertain its full behavior in different environments.

Interesting facts

Interesting Facts about 3-[(2-chloro-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-5-ium-11-yl)oxy]propyl-dimethyl-ammonium;dichloride

This compound belongs to a fascinating class of quaternary ammonium compounds that often exhibit unique properties due to their structural characteristics. Here are some compelling facts about this compound:

  • Quaternary Ammonium Structure: The presence of a quaternary nitrogen atom contributes to its positive charge, enhancing its interaction with various biological systems.
  • Cycloheptaquinoline Moiety: The incorporation of a cycloheptaquinoline core provides a complex cyclic structure, which can play a critical role in the compound's pharmacological activity.
  • Potential Biological Activity: Compounds containing similar moieties have been studied for their potential as antimicrobial and antiviral agents, highlighting the importance of structural diversity in drug design.
  • Surface Activity: As a quaternary ammonium salt, it may possess surfactant properties, which can be useful in formulations for pharmaceuticals and cosmetics.
  • Versatile Applications: Due to its unique chemical structure, this compound may find applications in various fields such as medicinal chemistry, material science, and agriculture.

As one considers the implications of such compounds, it's important to recognize that even a single atom or group can significantly alter its biological and chemical reactivity. As stated by chemist Linus Pauling, "The best way to have a good idea is to have a lot of ideas." This is particularly relevant when exploring the diverse world of chemical compounds like 3-[(2-chloro-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-5-ium-11-yl)oxy]propyl-dimethyl-ammonium;dichloride, where innovation and creativity can lead to novel discoveries.

Synonyms
5605-45-8
6H-Cyclohepta(b)quinoline, 2-chloro-11-(3-(dimethylamino)propoxy)-7,8,9,10-tetrahydro-, dihydrochloride
2-Chloro-11-(3-(dimethylamino)propoxy)-7,8,9,10-tetrahydro-6H-cyclohepta(b)quinoline 2HCl