Interesting facts
Discovering 3-(2-chlorophenothiazin-10-yl)-N,N-dimethyl-propan-1-amine
3-(2-chlorophenothiazin-10-yl)-N,N-dimethyl-propan-1-amine is a fascinating compound belonging to the family of phenothiazines, which are known for their wide application in the pharmaceutical industry. This compound exhibits properties that make it particularly significant in the treatment of mental health disorders. Here are some interesting facts:
- Pharmaceutical Applications: Many derivatives of phenothiazines, including this compound, are used as antipsychotic medications. They are known to influence neurotransmitter pathways, helping manage conditions like schizophrenia and bipolar disorder.
- Mechanism of Action: The compound primarily function by antagonizing dopamine receptors. This action can help reduce symptoms of psychosis by modulating the balance of neurotransmitters in the brain.
- Chemical Structure: The presence of the Cl (chlorine) atom in its structure greatly affects its pharmacological activity. Chlorine substitutions can enhance the compound's lipophilicity and receptor affinity.
- Historical Context: Phenothiazines were first synthesized in the 1930s, and their introduction into psychiatric treatment in the 1950s marked a major breakthrough in addressing severe mental health disorders.
- Research Potential: Ongoing research continues to explore the potential of similar compounds in treating other conditions, including antiemetic effects for nausea and vomiting.
Understanding compounds like 3-(2-chlorophenothiazin-10-yl)-N,N-dimethyl-propan-1-amine not only highlights their therapeutic properties but also provides insight into how chemical modifications can lead to substantially different biological activities. As researchers and students delve deeper into pharmacology, the significance of such compounds becomes increasingly evident.
Synonyms
chlorpromazine
50-53-3
Thorazine
Largactil
Chloropromazine
Aminazine
Contomin
Chlorderazin
Propaphenin
Chlorpromados
Fenactil
Sanopron
Wintermin
Esmind
Largactilothiazine
Megaphen
Novomazina
Chlorpromazinum
Chlorpromazin
Clorpromazina
Largactyl
Phenactyl
Promactil
Aminazin
Elmarin
Fenaktyl
Promazil
Torazina
2-Chloropromazine
Proma
Prozil
Chlor-Promanyl
Ampliactil
Psychozine
Fraction AB
3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine
Amplictil
Aminasine
10H-Phenothiazine-10-propanamine, 2-chloro-N,N-dimethyl-
SKF 2601-A
Chlor-PZ
HL 5746
BC 135
CPZ
Cromedazine
Plegomasine
Amplicitil
3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine
N-(3-Dimethylaminopropyl)-3-chlorophenothiazine
HSDB 3033
Chlorpromazinum [INN-Latin]
Clorpromazina [INN-Spanish]
4560 R.P.
3-(2-chlorophenothiazin-10-yl)-N,N-dimethyl-propan-1-amine
CCRIS 3711
CHEBI:3647
[3-(2-chloro-10H-phenothiazin-10-yl)propyl]dimethylamine
UNII-U42B7VYA4P
Hemoglobin kodaira
EINECS 200-045-8
U42B7VYA4P
2-Cloro-10 (3-dimetilaminopropil)fenotiazina
2-chloro-N,N-dimethyl-10H-Phenothiazine-10-propanamine
NSC 167745
NSC-167745
3-(2-Chloro-10H-phenothiazin-10-yl)-N,N-dimethyl-1-propanamine
34468-21-8
DTXSID0022808
2-Chloro-10-(3-(dimethylamino)propyl)phenothiazine
2-Chloro-10-[3-(dimethylamino)propyl]phenothiazine
Chloro-3 (dimethylamino-3 propyl)-10 phenothiazine
SKF-2601A
CHEMBL71
GG 407
NSC-226514
J2.794D
Phenothiazine, 2-chloro-10-(3-(dimethylamino)propyl)-
DTXCID002808
Chlorpromazine [USP:INN:BAN]
Phenothiazine hydrochloride
Hibanil
Unitensen
NSC167745
Phenothiazine, 2-chloro-10-[3-(dimethylamino)propyl]-
NCGC00015273-11
Thorazine Suppositories
Clorpromazina [Italian]
Chlorpromazinum (INN-Latin)
Clorpromazina (INN-Spanish)
146702-01-4
CHLORPROMAZINE (MART.)
CHLORPROMAZINE [MART.]
Chlorpromazine (USP:INN:BAN)
Prazilpromactil
Chlordelazin
Phenathyl
chlorpromethazine
CHLORPROMAZINE (USP MONOGRAPH)
CHLORPROMAZINE [USP MONOGRAPH]
CAS-50-53-3
Thorazine (TN)
Z80
chlorpromazine cation
[3-(2-chloro-10H-phenothiazin-10-yl)propyl]dimethylamine hydrochloride
CAS-69-09-0
phenothiazine, 2-chloro-10-(3-dimethylaminopropyl)-
Chlorpromazine (USP/INN)
Chlorpromazine cation radical
Amplicatil
Chlropromados
Fraction
2-Cloro-10 (3-dimetilaminopropil)fenotiazina [Italian]
JHICC02042
Chloro-3 (dimethylamino-3 propyl)-10 phenothiazine [French]
SKF 2601A
SKF-2601
MFCD00133295
Hibernal (Salt/Mix)
Lomazine (Salt/Mix)
Tranzine (Salt/Mix)
Norcozine (Salt/Mix)
Spectrum_000142
Prestwick0_000064
Prestwick1_000064
Prestwick2_000064
Prestwick3_000064
Spectrum2_001156
Spectrum3_000346
Spectrum4_000283
Spectrum5_000717
Lopac-C-8138
Biomol-NT_000020
Epitope ID:136898
GTPL83
10H-Phenothiazine-10-propanamine, 2-chloro-N,N-dimethyl-, radical ion(1+)
CHLORPROMAZINE [MI]
SCHEMBL8321
CHLORPROMAZINE [INN]
10-(3-Dimethylaminopropyl)-2-chlorophenothiazine
2-Chloro-10-(3-dimethylaminopropyl)phenothiazine
Lopac0_000249
Oprea1_110255
BSPBio_000247
BSPBio_002011
CHLORPROMAZINE [HSDB]
KBioGR_000806
KBioGR_002312
KBioSS_000622
KBioSS_002314
MLS003166901
CHLORPROMAZINE [VANDF]
CHLORPROMAZINUM [HPUS]
DivK1c_000624
SPECTRUM1500184
2-chloro-10-(3-(dimethylamino)propyl)-phenothiazine
SPBio_001111
SPBio_002168
BPBio1_000273
BPBio1_001181
QSPL 401
CHLORPROMAZINE [WHO-DD]
HMS501P06
KBio1_000624
KBio2_000622
KBio2_002312
KBio2_003190
KBio2_004880
KBio2_005758
KBio2_007448
KBio3_001231
KBio3_002792
A10BB02
N05AA01
N05AF03
cMAP_000017
NINDS_000624
Bio1_000457
Bio1_000946
Bio1_001435
HMS1920M03
HMS2089C12
HMS2091E06
HMS3430C19
HMS3886G22
KUC112482N
Pharmakon1600-01500184
ALBB-022464
BCP03610
CHLORPROMAZINE [ORANGE BOOK]
Tox21_110120
BBL028251
BDBM50001888
CCG-40059
NSC756661
NSC756689
s5749
STK182870
AKOS001490972
Tox21_110120_1
4560 RP
DB00477
FC40106
KS-5101
NSC-756661
NSC-756689
RP-4560
SDCCGSBI-0050237.P005
IDI1_000624
PS31 - Chlorpromazine/Norchlorpromazine
QTL1_000021
NCGC00015273-01
NCGC00015273-02
NCGC00015273-03
NCGC00015273-04
NCGC00015273-05
NCGC00015273-06
NCGC00015273-07
NCGC00015273-08
NCGC00015273-09
NCGC00015273-10
NCGC00015273-12
NCGC00015273-13
NCGC00015273-14
NCGC00015273-15
NCGC00015273-16
NCGC00015273-17
NCGC00015273-19
NCGC00015273-31
NCGC00024409-04
NCGC00024409-05
NCGC00024409-06
NCGC00024409-07
NCGC00024409-08
KSC-315-032-
SMR001453710
2-chloro-10-[3-(dimethylamino)propyl]-
SBI-0050237.P004
WLN: T C666 BN ISJ B3N1&1 EG
2601A
AB00051943
NS00001759
2601-A
C06906
D00270
G77950
AB00051943-15
AB00051943-16
AB00051943_17
AB00051943_18
3-Chloro-10-(3-dimethylaminopropyl)phenothiazine
L000182
Q407972
SR-01000000012-5
SR-01000000012-6
2-Chloro-10-(N-dimethylamino-n-propyl)-phenothiazine
BRD-K89997465-001-05-3
BRD-K89997465-001-10-3
BRD-K89997465-003-43-0
BRD-K89997465-003-44-8
10h-phenothiazine-10-propanamine, 2-chloro-n,n-dimethyl
1N,1N-dimethyl-3-(2-chloro-10H-10-phenothiazinyl)-1-propanamine
3-(2-Chloro-10H-phenothiazin-10-yl)-N,N-dimethyl-1-propanamine #
3-(2-Chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan1-amine
(chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine
(chlorpromazine)[3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine
[3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine (chlor-promazine)
[3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine( Chlorpromazine)
[3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine(clorpromazine)
Chlorpromazine;[3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine
200-045-8
Solubility of 3-(2-chlorophenothiazin-10-yl)-N,N-dimethyl-propan-1-amine (C17H19ClN2S)
The solubility of 3-(2-chlorophenothiazin-10-yl)-N,N-dimethyl-propan-1-amine is an intriguing characteristic that can significantly impact its applications in various fields. The compound's solubility can be influenced by factors such as:
Furthermore, “the nature of the solvent” is crucial when determining solubility. Many organic compounds, including tertiary amines like this one, often show better solubility in organic solvents such as:
In conclusion, the solubility of 3-(2-chlorophenothiazin-10-yl)-N,N-dimethyl-propan-1-amine is influenced by its unique molecular structure and the environment in which it is placed. Understanding these solubility properties is essential for effective application in pharmaceuticals and related fields.