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Chlorpromazine Hydrochloride

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Identification
Molecular formula
C17H20ClN3S · HCl
CAS number
69-09-0
IUPAC name
3-(2-chlorophenothiazin-10-yl)-N,N-dimethyl-propan-1-amine;hydrochloride
State
State

Chlorpromazine Hydrochloride is a solid at room temperature, typically prepared in a laboratory setting as a powder or within pharmaceutical preparations for medicinal uses.

Melting point (Celsius)
196.00
Melting point (Kelvin)
469.15
Boiling point (Celsius)
424.20
Boiling point (Kelvin)
697.35
General information
Molecular weight
355.33g/mol
Molar mass
355.3170g/mol
Density
1.3000g/cm3
Appearence

Chlorpromazine Hydrochloride appears as a white or creamy-white crystalline powder. It is often odorless or may have a faint characteristic odor. When exposed to air or light, it might turn light gray or pink upon prolonged exposure. The compound is usually prepared in tablet form or as an injectable solution for medical use.

Comment on solubility

Solubility of 3-(2-chlorophenothiazin-10-yl)-N,N-dimethyl-propan-1-amine; hydrochloride

The compound 3-(2-chlorophenothiazin-10-yl)-N,N-dimethyl-propan-1-amine; hydrochloride (C17H20ClN3S · HCl) exhibits a range of solubility characteristics that are important for its applications.

Solubility Characteristics:

  • Aqueous Solubility: The hydrochloride form of this compound is likely to be soluble in water due to the presence of the hydrochloride salt, which typically enhances solubility in polar solvents.
  • Solvent Interactions: It may exhibit higher solubility in organic solvents such as ethanol and dimethyl sulfoxide (DMSO), allowing for versatile applications in various formulations.
  • pH Influence: The solubility could be influenced by the pH of the solution; as with many hydrochloride salts, the acid-base balance is critical in determining solubility behavior.
  • Temperature Dependency: There may be an increase in solubility at elevated temperatures, which is a common trait for many compounds.

Overall, the solubility profiles of compounds like this one are crucial as they dictate their bioavailability, efficacy, and suitability for formulation in pharmaceutical contexts. Understanding these properties enables better handling and application in scientific and medical pursuits.

Interesting facts

Interesting Facts about 3-(2-chlorophenothiazin-10-yl)-N,N-dimethyl-propan-1-amine; hydrochloride

This intriguing compound, often discussed in the context of pharmacology and medicinal chemistry, has garnered attention due to its unique structure and properties. Here are some fascinating points about this compound:

  • Dual Functionality: As a derivative of phenothiazine, this compound combines the properties of both phenothiazine and amine, providing possibilities for various biological activities. Its design allows for interactions with a range of biological targets.
  • Pharmacological Applications: Compounds like this one, due to their phenothiazine structure, are often explored for their potential as antipsychotics and antidepressants, targeting neurotransmitter pathways in the brain.
  • Synthesis Insights: The synthesis of this compound typically involves multi-step reactions that require careful control of reaction conditions, highlighting the complexity and creativity involved in modern synthetic organic chemistry.
  • Chlorine's Role: The presence of the chlorine atom enhances the compound's pharmacological activity by improving its binding affinity to various receptors, which is a common strategy in drug design called "bioisosteric replacement."
  • Dynamic Interactions: Upon administration, the hydrochloride salt form allows for better solubility and bioavailability, showcasing the importance of salt forms in drug formulation.

In the words of a prominent chemist, "Molecules tell stories, and the narratives of their interactions can change the lives of many." This compound serves as a fantastic example of how understanding chemical structure can lead to breakthroughs in therapeutic applications.

Exploring compounds like 3-(2-chlorophenothiazin-10-yl)-N,N-dimethyl-propan-1-amine; hydrochloride not only deepens our comprehension of chemistry but also opens doors for novel treatment options in medicine.

Synonyms
Chlorpromazine hydrochloride
69-09-0
Chlorpromazine Hcl
Sonazine
Chloractil
Klorproman
Marazine
Norcozine
Klorpromex
Plegomazin
Promacid
Promapar
Hebanil
Hibernal
Hybernal
Lomazine
Neurazine
Promachel
Promexin
Taroctyl
Tranzine
Chlorpromazinium chloride
NCI-C05210
Unitensen
Chloropromazine monohydrochloride
Propaphen
Chlorpromazine (hydrochloride)
Aminazin monohydrochloride
Fenactil monohydrochloride
[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-dimethylamine hydrochloride
Ampliactil monohydrochloride
Hibanil
CHLOROPROMAZINE HYDROCHLORIDE
Thorazine hydrochloride
Chlorpromazine monohydrochloride
Largaktyl
CHEBI:3649
DTXSID7024827
Chlorpromazine chloride
10-(3-Dimethylaminopropyl)-2-chlorophenothiazine monohydrochloride
4560 Rp hydrochloride
Chlorpromazine Hydrochloride Intensol
MFCD00012654
9WP59609J6
3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine hydrochloride
Chlorpromazin-d6 hydrochloride
MLS000069401
DTXCID404827
Phenothiazine hydrochloride
Chlorpromazine.HCl
2-Chloro-10-(3-(dimethylamino)propyl)phenothiazine monohydrochloride
3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine;hydrochloride
NSC17479
10H-Phenothiazine-10-propanamine, 2-chloro-N,N-dimethyl-, monohydrochloride
NSC-17479
69-09-0 (HCl)
Aminazinum
Megatil
SMR000058254
2-Chloro-10-(3-dimethylaminopropyl)phenothiazine hydrochloride
Phenothiazine, 2-chloro-10-(3-(dimethylamino)propyl)-, monohydrochloride
Chlorpromazine, Hydrochloride
Contomin hydrochloride
Megaphen hydrochloride
2-Chloro-10-(3-dimethylaminopropyl)phenothiazine monohydrochloride
Largactil monohydrochloride
CPZ (VAN)
CHLORPROMAZINE HYDROCHLORIDE (MART.)
CHLORPROMAZINE HYDROCHLORIDE [MART.]
CCRIS 6221
CHLORPROMAZINE HYDROCHLORIDE (USP-RS)
CHLORPROMAZINE HYDROCHLORIDE [USP-RS]
[3-(2-chloro-10H-phenothiazin-10-yl)propyl]dimethylamine hydrochloride
CAS-69-09-0
Propaphenin hydrochloride
CHLORPROMAZINE HYDROCHLORIDE (EP IMPURITY)
CHLORPROMAZINE HYDROCHLORIDE (EP MONOGRAPH)
CHLORPROMAZINE HYDROCHLORIDE [EP IMPURITY]
CHLORPROMAZINE HYDROCHLORIDE [EP MONOGRAPH]
SR-01000000012
CHLORPROMAZINE HYDROCHLORIDE (USP MONOGRAPH)
CHLORPROMAZINE HYDROCHLORIDE [USP MONOGRAPH]
EINECS 200-701-3
NSC 17479
2-Chloro-10-[3-(dimethylamino)propyl]phenothiazine monohydrochloride
AI3-28023
UNII-9WP59609J6
Prestwick_58
Sonazine (TN)
Chlorpromazine HCl?
2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine monohydrochloride
CHLORPROMAZINE HCI
AC1LCWF1
Chlorpromazine hydrochloride [USP:BAN:JAN]
Opera_ID_1294
Chlorpromazini hydrochloridum
AMINAZIN HYDROCHLORIDE
CHEMBL1713
Hydrochloride, Chlorpromazine
SCHEMBL41771
MLS001148603
MLS002222157
HY-B0407A
Chlorpromazine hydrochloride, 98%
HMS1568M09
BCP30284
DZB18246
Tox21_300517
Tox21_500249
NSC226514
s2456
AKOS005111082
CCG-220064
CCG-221553
LP00249
NC00552
Chlorpromazine hydrochloride (JP17/USP)
CHLORPROMAZINE HYDROCHLORIDE [MI]
NCGC00024409-09
NCGC00093711-01
NCGC00093711-02
NCGC00180973-01
NCGC00254272-01
NCGC00260934-01
AC-10573
CHLORPROMAZINE HYDROCHLORIDE [JAN]
LS-14587
CHLORPROMAZINE HYDROCHLORIDE [VANDF]
C2481
CHLORPROMAZINE HYDROCHLORIDE [WHO-DD]
CHLORPROMAZINE HYDROCHLORIDE [WHO-IP]
Chlorpromazine hydrochloride, >=98% (TLC)
EU-0100249
NS00078900
SW196373-5
EN300-20245
C 8138
C07952
Chlorpromazine, Hydrochloride - CAS 69-09-0
D00789
D89519
MLS-0090820.0001
CHLORPROMAZINE HYDROCHLORIDE [GREEN BOOK]
WLN: T C666 BN ISJ B3N1&1 EG &GH
CHLORPROMAZINE HYDROCHLORIDE [ORANGE BOOK]
CHLORPROMAZINI HYDROCHLORIDUM [WHO-IP LATIN]
SR-01000000012-2
SR-01000000012-9
Q27106159
Chlorpromazine.HCl, 1mg/ml in Methanol (as free base)
Z104477466
2-chloro-10-(3-dimethylaminopropyl) phenothiazine hydrochloride
Chlorpromazine hydrochloride, meets USP testing specifications
Chlorpromazine hydrochloride, VETRANAL(TM), analytical standard
2-Chloro-10-[3-(dimethylamino)-1-propyl]phenothiazine Hydrochloride
Chlorpromazine Hydrochloride 1.0 mg/ml in Methanol (as free base)
10H-phenothiazine-10-propanamine hydrochloride, 2-chloro-N,N-dimethyl-
Chlorpromazine hydrochloride, European Pharmacopoeia (EP) Reference Standard
10H-Phenothiazine-10-propanamine, 2-chloro-N,N-dimethyl-, hydrochloride (1:1)
3-(2-Chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropylamine monohydrochloride
Chlorpromazine hydrochloride, United States Pharmacopeia (USP) Reference Standard
PHENOTHIAZINE-10-PROPANAMINE, 2-CHLORO-N,N-DIMETHYL-, MONOHYDROCHLORIDE
200-701-3