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Chlorpromazine

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Identification
Molecular formula
C17H19ClN2S
CAS number
50-53-3
IUPAC name
3-(2-chlorophenothiazin-10-yl)propyl-trimethyl-ammonium
State
State

At room temperature, chlorpromazine is typically found in a solid state.

Melting point (Celsius)
190.00
Melting point (Kelvin)
463.20
Boiling point (Celsius)
523.90
Boiling point (Kelvin)
797.10
General information
Molecular weight
355.32g/mol
Molar mass
355.3170g/mol
Density
1.2800g/cm3
Appearence

Chlorpromazine typically appears as a white to off-white crystalline powder. It is very slightly soluble in water but more soluble in organic solvents like chloroform and ethanol.

Comment on solubility

Solubility of 3-(2-chlorophenothiazin-10-yl)propyl-trimethyl-ammonium

The solubility of 3-(2-chlorophenothiazin-10-yl)propyl-trimethyl-ammonium can be intriguing due to its complex structure. Several factors influence the solubility of this compound:

  • Polar vs Non-Polar Nature: Being a quaternary ammonium compound, it exhibits significant polarity, which often enhances its solubility in polar solvents like water or alcohols.
  • Substituents: The presence of the 2-chlorophenothiazine group may affect its hydrophobic and hydrophilic balance, potentially leading to differing solubility characteristics.
  • Concentration: The solubility might vary with concentration - higher concentrations can lead to saturation points, affecting dissolution rates.
  • Temperature: Typically, increasing temperature improves solubility, especially for organic compounds.

Important considerations when dealing with solubility include:

  1. Determining if the compound can form hydrogen bonds with the solvent.
  2. Assessing whether the ionic nature of the ammonium group facilitates ion-dipole interactions.
  3. Understanding the impact of pH levels in solutions which may alter the charge and, consequently, solubility.

In summary, the solubility of 3-(2-chlorophenothiazin-10-yl)propyl-trimethyl-ammonium is influenced by its polarity, structural components, temperature, and the solvent used. Further investigation may reveal interesting applications based on its solubility properties.

Interesting facts

Interesting Facts about 3-(2-chlorophenothiazin-10-yl)propyl-trimethyl-ammonium

3-(2-chlorophenothiazin-10-yl)propyl-trimethyl-ammonium is a compound that piques the interest of many in the field of medicinal chemistry. This compound is notably linked to various therapeutic applications due to its biological activity. Here are some interesting insights:

  • Therapeutic Potential: This compound is a derivative of phenothiazine, a class of medications that are widely used as antipsychotic agents. The structure of phenothiazines enables a range of interactions at various biological targets, making them effective in treating psychiatric disorders.
  • Quaternary Ammonium Ion: The presence of the trimethyl-ammonium group imparts a permanent positive charge to the molecule. This characteristic can enhance the compound's solubility in aqueous environments and may influence its pharmacokinetic properties.
  • Chlorine Substitution: The 2-chloro substitution on the phenothiazine ring not only aids in modulating the biological activity but also impacts the electronic properties of the compound. Such modifications can lead to a variation in the efficacy and safety profile of the resulting drug.
  • Research Applications: Ongoing research is investigating the potential of compounds like this one in treating other conditions, including anxiety disorders and certain types of cancer, due to their diverse mechanism of action.
  • Designer Drugs: This compound exemplifies the strategy of drug design where structural modifications are made to enhance desired effects while minimizing side effects. This could lead to more targeted and effective therapies for patients.

In summary, 3-(2-chlorophenothiazin-10-yl)propyl-trimethyl-ammonium stands out in the chemical landscape due to its essential role in the development of therapeutic agents. Understanding its properties and applications continues to be an exciting area of research for chemists and medical scientists alike.

Synonyms
19077-31-7
10H-Phenothiazine-10-propanaminium, 2-chloro-N,N,N-trimethyl-
Methochlorpromazine
Methylchlorpromazine
N-Methyl chlorpromazine
Quaternary-chlorpromazine
Q-CPZ
CHEMBL279905
SK&F 2680-J
3-(2-chlorophenothiazin-10-yl)propyl-trimethylazanium
SCHEMBL9570329
CHEMBL1183102
DTXSID40940653
BDBM50019879
[3-(2-Chloro-phenothiazin-10-yl)-propyl]-trimethyl-ammonium; iodide
3-(2-chloro-10H-phenothiazin-10-yl)-N,N,N-trimethylpropan-1-aminium