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Clonazolam

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Identification
Molecular formula
C17H12ClN3O
CAS number
33887-02-4
IUPAC name
3-(2-chlorophenyl)-2-methyl-quinazolin-4-one
State
State

Clonazolam is typically found in a solid state at room temperature, usually as a crystalline powder.

Melting point (Celsius)
250.00
Melting point (Kelvin)
523.15
Boiling point (Celsius)
531.30
Boiling point (Kelvin)
804.45
General information
Molecular weight
353.78g/mol
Molar mass
353.7760g/mol
Density
1.3400g/cm3
Appearence

Clonazolam usually appears as a white to pale yellow crystalline powder. Its appearance can also vary depending on the purity and form it is in, but it is generally quite uniform in texture.

Comment on solubility

Solubility of 3-(2-chlorophenyl)-2-methyl-quinazolin-4-one

The solubility of 3-(2-chlorophenyl)-2-methyl-quinazolin-4-one is influenced by various factors, such as temperature, solvent choice, and molecular structure. Understanding its solubility characteristics can provide insights into its behavior in different environments.

Key Factors Affecting Solubility:

  • Temperature: Generally, an increase in temperature can enhance solubility, allowing more of the compound to dissolve in a given solvent.
  • Polarity of the Solvent: This compound may have limited solubility in polar solvents due to its relatively non-polar characteristics, suggesting that non-polar or slightly polar solvents may be more effective.
  • Molecular Structure: The presence of the 2-chlorophenyl group may introduce significant steric hindrance, potentially affecting how well the compound interacts with solvent molecules.

Moreover, it is essential to consider the following solubility aspects:

  • Some compounds can be classified as sparingly soluble, which means they dissolve slightly but not significantly in solvents.
  • The crystalline structure of the compound may also play a role, as more ordered structures often exhibit lower solubility.
  • Solubility trends in small organic molecules, particularly in pharmaceutical applications, are critical for understanding bioavailability.

In conclusion, the solubility of 3-(2-chlorophenyl)-2-methyl-quinazolin-4-one can vary significantly based on the aforementioned factors. Researchers often conduct experiments to determine specific solubility values under controlled conditions to provide precise data.

Interesting facts

Interesting Facts about 3-(2-chlorophenyl)-2-methyl-quinazolin-4-one

3-(2-chlorophenyl)-2-methyl-quinazolin-4-one is a fascinating compound that belongs to the quinazoline family, which is known for its diverse biological activities. Here are some intriguing aspects of this particular compound:

  • Biological Significance: Quinazolines, including this compound, are often studied for their potential pharmaceutical applications. They have shown promising activity against various diseases, making them candidates for drug development.
  • Antimicrobial Properties: Several derivatives of quinazoline are noted for their antimicrobial effects. This particular compound may exhibit similar tendencies, warranting further research into its effectiveness against pathogens.
  • Structure-Activity Relationship: The inclusion of the 2-chlorophenyl group is of significant interest. The electronic and steric properties of the chlorine atom can influence the overall reactivity and interaction of the molecule with biological targets.
  • Applications in Medicinal Chemistry: The versatility of quinazoline derivatives makes them useful in the synthesis of new compound libraries aimed at targeting cancer and other diseases.
  • Complexity of Synthesis: The synthesis of 3-(2-chlorophenyl)-2-methyl-quinazolin-4-one can be quite complex, often involving multiple reaction steps and specific conditions to achieve the desired purity and yield.

As a compound of interest in both academic and pharmaceutical research, 3-(2-chlorophenyl)-2-methyl-quinazolin-4-one serves as a reminder of the intricate relationship between molecular structure and biological activity. Continued exploration of such compounds can lead to significant advancements in drug discovery and therapeutic development.

Synonyms
MECLOQUALONE
Mecloqualon
Nubarene
Casfen
340-57-8
B 208-Tropon
Meclocualona
CHI 8
Mecloqualonum
NSC-142005
W 4744
Mecloqualone [USAN:INN]
4(3H)-Quinazolinone, 3-(2-chlorophenyl)-2-methyl-
Mecloqualonum [INN-Latin]
Meclocualona [INN-Spanish]
2-Methyl-3-(2-chlorophenyl)chinazolon-4
3-(o-Chlorophenyl)-2-methyl-4(3H)-quinazolinone
2-Methyl-3-(o-chlorophenyl)-4-quinazolinone
NSC 142005
B 208
EINECS 206-432-8
09XU4VDV7E
BRN 0228324
DTXSID7048875
4(3H)-Quinazolinone, 3-(o-chlorophenyl)-2-methyl-
MECLOQUALONE [MI]
MECLOQUALONE [INN]
MECLOQUALONE [USAN]
3-(2-Chlorophenyl)-2-methyl-4(3H)-quinazolinone
DTXCID7028801
W-4744
3-(2-Chloro-phenyl)-2-methyl-3H-quinazolin-4-one
NSC631629
NCGC00247713-01
3-(o-Chlorophenyl)-2-methyl-4-quinazolone
Mecloqualonum (INN-Latin)
Meclocualona (INN-Spanish)
3-(2-chlorophenyl)-2-methylquinazolin-4-one
UNII-09XU4VDV7E
DEA No. 2572
MECLAQUALONE
BAS 04894077
Mecloqualone (USAN/INN)
SCHEMBL113419
CHEMBL279960
CHEBI:135113
Tox21_112870
NSC142005
STK860296
AKOS000663205
NSC-631629
CAS-340-57-8
WLN: T66 BVN ENJ CR BG & D1
2-Methyl-3-(o-chlorophenyl)-4-quinazolone
NS00029606
3-(2-chlorophenyl)-2-methyl-quinazolin-4-one
D04877
3-(2-chlorophenyl)-2-methylquinazolin-4(3H)-one
SR-01000323300
Q6804828
SR-01000323300-1
3-(2-chloro-phenyl)-2-methyl-3,4-dihydro-quinazolin-4-one
206-432-8