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Prazosin

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Identification
Molecular formula
C19H21N3S
CAS number
19216-56-9
IUPAC name
3-[2-(diethylamino)ethyl]quinazoline-4-thione
State
State

At room temperature, prazosin is typically in a solid state, appearing as a crystalline powder due to its high melting point. It is used pharmaceutically mainly in the form of its hydrochloride salt, giving it stability and solubility necessary for medicinal applications.

Melting point (Celsius)
276.00
Melting point (Kelvin)
549.00
Boiling point (Celsius)
255.00
Boiling point (Kelvin)
528.10
General information
Molecular weight
327.42g/mol
Molar mass
327.4210g/mol
Density
1.2632g/cm3
Appearence

Prazosin hydrochloride is an off-white to white crystalline powder. It is known for its light sensitivity, where it may gradually darken upon prolonged exposure. The compound is slightly soluble in water and ethanol, but practically insoluble in chloroform and ether.

Comment on solubility

Solubility of 3-[2-(diethylamino)ethyl]quinazoline-4-thione

The solubility of 3-[2-(diethylamino)ethyl]quinazoline-4-thione can be influenced by various factors, including its molecular structure and the presence of functional groups.

Key Points on Solubility:

  • Polarity: The presence of a diethylamino group often increases the polarity of the molecule, which can enhance its solubility in polar solvents such as water.
  • Hydrogen Bonding: This compound may engage in hydrogen bonding, affecting its solubility profile. Compounds with functional groups capable of forming hydrogen bonds typically have improved solubility in polar solvents.
  • Organic Solvents: It is also likely soluble in several organic solvents, including ethanol, methanol, and dimethyl sulfoxide (DMSO), due to the flexible nature of its alkyl substituents.
  • pH Dependence: The solubility may vary with pH, as protonation of the amine group may influence dissolution in aqueous environments.

As a rule of thumb, you can expect that compounds with a blend of polar and nonpolar characteristics will exhibit variable solubility trends based on the solvent used. It is always recommended to conduct empirical tests to determine the specific solubility of 3-[2-(diethylamino)ethyl]quinazoline-4-thione under various conditions.

Interesting facts

Interesting Facts about 3-[2-(diethylamino)ethyl]quinazoline-4-thione

3-[2-(diethylamino)ethyl]quinazoline-4-thione is an intriguing compound with various applications in the field of medicinal chemistry. Below are some engaging details that highlight its significance:

  • Structure and Functionality: The compound features a quinazoline core, which is known for its diverse biological activities. This makes it a topic of interest among researchers investigating novel drug candidates.
  • Biological Activity: Quinazolines are often associated with antitumor, anticonvulsant, and antihypertensive properties, which make them valuable in pharmacology. The presence of the diethylamino side chain can enhance the cell permeability and efficacy of this compound.
  • Research Applications: This compound has gained attention in studies focused on cancer therapies. The thione functional group can participate in various chemical reactions, potentially revealing new therapeutic pathways.
  • Analytical Techniques: Characterizing 3-[2-(diethylamino)ethyl]quinazoline-4-thione often involves sophisticated analytical techniques such as NMR spectroscopy, mass spectrometry, and X-ray crystallography, which help elucidate its structure and behavior.
  • Future Directions: Ongoing research aims to explore its derivatives and analogs in the hope of discovering new drugs that target specific biopathways in diseases.
    "The journey of discovery is as significant as the findings themselves."

In conclusion, scientists are continually drawn to 3-[2-(diethylamino)ethyl]quinazoline-4-thione for its potential in advancing our understanding of complex biological systems and developing new therapeutic agents. Its unique properties make it a valuable compound worthy of further exploration.

Synonyms
0HN37A9JXD
3-(2-Diethylaminoethyl)quinazola-4-thione
UNII-0HN37A9JXD
4(3H)-Quinazolinethione, 3-(2-(diethylamino)ethyl)-
22204-73-5
RefChem:198176