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Leflunomide

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Identification
Molecular formula
C12H9F3N2O2
CAS number
75706-12-6
IUPAC name
3-(2-hydroxyethyl)-1-(4-methoxyphenyl)-1,3-diazaspiro[4.5]decane-2,4-dione
State
State

At room temperature, Leflunomide is typically found as a solid.

Melting point (Celsius)
163.50
Melting point (Kelvin)
436.65
Boiling point (Celsius)
570.00
Boiling point (Kelvin)
843.15
General information
Molecular weight
270.28g/mol
Molar mass
270.2750g/mol
Density
1.3000g/cm3
Appearence

The compound typically appears as a white to off-white powder.

Comment on solubility

Solubility of 3-(2-hydroxyethyl)-1-(4-methoxyphenyl)-1,3-diazaspiro[4.5]decane-2,4-dione

The solubility of 3-(2-hydroxyethyl)-1-(4-methoxyphenyl)-1,3-diazaspiro[4.5]decane-2,4-dione is influenced by several factors, primarily due to its complex structure containing both hydrophilic and hydrophobic components. Here are some key points regarding its solubility:

  • Hydrophilic Traits: The presence of the hydroxyethyl group enhances the polar nature of the molecule, potentially increasing solubility in polar solvents such as water.
  • Hydrophobic Traits: The methoxyphenyl ring contributes a non-polar character, which may limit the solubility in purely aqueous environments.
  • Solvent Interaction: The compound is likely to exhibit variable solubility depending on the solvent system employed. For instance, it may dissolve better in organic solvents like ethanol or acetone compared to water.
  • pH Sensitivity: The solubility might also change with pH alterations, as the ionization of functional groups could affect its overall solubility dynamics.

In conclusion, evaluating the solubility of this compound necessitates considering its diverse interactions, which can be summarized with the quote: "Solubility is the key; it opens the door to understanding chemical behavior." Thus, when testing its solubility, it is imperative to conduct experiments in varying solvent conditions for accurate characterization.

Interesting facts

Interesting Facts about 3-(2-hydroxyethyl)-1-(4-methoxyphenyl)-1,3-diazaspiro[4.5]decane-2,4-dione

This compound, with its intriguing structure, is not just another organic molecule—it represents a fascinating intersection of chemistry and potential application in medicinal fields. Here are some interesting aspects:

  • Structural Complexity: The compound features a spirocyclic structure, which is characterized by two or more rings that share a single atom. This unique architecture can play a crucial role in the biological activity of the compound.
  • Biological Relevance: Compounds like this one are often synthesized for their potential therapeutic properties. Its structural similarities to known pharmaceuticals may make it a candidate for research into new drug development.
  • Hydroxyl Group Influence: The presence of a hydroxyl (–OH) group in the molecule enhances its solubility in polar solvents and can significantly influence its reactivity and interaction with biological systems.
  • Role of the Methoxy Group: The methoxy (–OCH3) group is known for its electron-donating effects, which may increase the compound's stability and modify its reactivity, potentially making it more effective in various chemical reactions.
  • Cross-Disciplinary Impact: Researchers from fields such as medicinal chemistry, pharmacology, and materials science may find interest in this compound, highlighting its relevance across multiple scientific disciplines.

In summary, 3-(2-hydroxyethyl)-1-(4-methoxyphenyl)-1,3-diazaspiro[4.5]decane-2,4-dione is a compound that not only showcases the beauty of chemical architecture but also holds promise for future scientific exploration. As we delve deeper into its properties and potential applications, we may uncover novel uses that benefit various industries.

Synonyms
741-39-9
BRN 0840988
1,3-DIAZASPIRO(4.5)DECANE-2,4-DIONE, 3-(2-HYDROXYETHYL)-1-(p-METHOXYPHENYL)-
DTXSID50225009
3'-(2-Hydroxyethyl)-1'-(p-methoxyphenyl)cyclohexanespiro-5'-hydantoin
DTXCID00147500
5-24-07-00301 (beilstein handbook reference)