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3-(2-hydroxyphenyl)propanamide

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Identification
Molecular formula
C9H11NO2
CAS number
7681-10-3
IUPAC name
3-(2-hydroxyphenyl)propanamide
State
State

At room temperature, 3-(2-hydroxyphenyl)propanamide is typically a solid.

Melting point (Celsius)
108.00
Melting point (Kelvin)
381.15
Boiling point (Celsius)
344.20
Boiling point (Kelvin)
617.35
General information
Molecular weight
165.19g/mol
Molar mass
165.1900g/mol
Density
1.1796g/cm3
Appearence

The compound 3-(2-hydroxyphenyl)propanamide appears as a white to off-white crystalline solid. Its appearance may vary slightly due to different forms or impurities.

Comment on solubility

Solubility of 3-(2-hydroxyphenyl)propanamide

The solubility of 3-(2-hydroxyphenyl)propanamide, also known as 3-(2-hydroxyphenyl)propionamide, is influenced by various factors due to its chemical structure. This compound contains both hydrophilic (water-attracting) and hydrophobic (water-repelling) components:

  • Hydroxyl group: The presence of the -OH (hydroxyl) group significantly enhances its solubility in polar solvents, particularly water.
  • Amide bond: The carbonyl group in the amide functional group can engage in hydrogen bonding with water, promoting further solubility.

However, the aromatic ring contributes to its hydrophobic character, which can slightly inhibit solubility in highly polar solvents. As a result, the overall solubility can be summarized as:

  1. Better solubility in: Polar solvents such as water and alcohols.
  2. Poorer solubility in: Nonpolar solvents like hexane and toluene.

In conclusion, while 3-(2-hydroxyphenyl)propanamide demonstrates good solubility in polar environments, its aromatic characteristics and hydrophobic nature render it less soluble in nonpolar conditions. This balance between polar and nonpolar properties is vital for its interactions in various chemical processes.

Interesting facts

Interesting Facts About 3-(2-hydroxyphenyl)propanamide

3-(2-hydroxyphenyl)propanamide, often referred to in scientific literature as a derivative of propanamide, is an intriguing compound with several noteworthy aspects.

Chemical Significance

  • Phenolic Influence: The presence of the 2-hydroxyphenyl group plays a significant role in the properties of this compound, contributing to its potential antioxidant activities.
  • Biological Activity: Compounds with a similar structure are known for their biological activities, making them of interest in pharmacology and medicinal chemistry.
  • Functional Group Interactions: The amide functional group can engage in various hydrogen bonding interactions, which can influence the compound's reactivity and solubility in different environments.

Potential Applications

  • Pharmaceutical Development: Research on this compound could lead to the discovery of new drugs that target specific enzymes or receptors in the human body.
  • Material Science: Its chemical structure may find applications in the development of novel materials, particularly in polymers and coatings.

Research Insights

Studies have indicated that compounds similar to 3-(2-hydroxyphenyl)propanamide may possess anti-inflammatory and antioxidant properties, which could inform its use in therapeutic contexts.

Conclusion

While still under research, the unique structure of 3-(2-hydroxyphenyl)propanamide presents exciting possibilities in various fields, particularly in medicinal chemistry. As more studies are conducted, we may uncover even more applications and significance of this compound in science and industry.

Synonyms
3-(2-hydroxyphenyl)propanamide
22367-76-6
3-(2-Hydroxyphenyl)propionamide
2-HYDROXYBENZENEPROPANAMIDE
MFCD03788457
Esmolol Impurity 59
SCHEMBL860002
SCHEMBL23805012
DTXSID70176903
LDJLLJYEHWTXLF-UHFFFAOYSA-N
XAA36776
AKOS009139194
BS-16670
DA-07975
SY316298
CS-0149941
D84146
EN300-1718985
F336886
Z371352778