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Methotrimeprazine

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Identification
Molecular formula
C19H24N2O
CAS number
60-99-1
IUPAC name
3-(2-methoxyphenothiazin-10-yl)-N,N,2-trimethyl-propan-1-amine
State
State

At room temperature, Methotrimeprazine is typically found in a solid state, appearing as a crystalline powder.

Melting point (Celsius)
32.00
Melting point (Kelvin)
305.15
Boiling point (Celsius)
318.00
Boiling point (Kelvin)
591.15
General information
Molecular weight
327.48g/mol
Molar mass
327.4790g/mol
Density
1.1300g/cm3
Appearence

Methotrimeprazine usually appears as a white to off-white crystalline powder. It is odourless and its solid form is typically stable under recommended storage conditions.

Comment on solubility

Solubility of 3-(2-methoxyphenothiazin-10-yl)-N,N,2-trimethyl-propan-1-amine

The solubility of the compound 3-(2-methoxyphenothiazin-10-yl)-N,N,2-trimethyl-propan-1-amine (C19H24N2O) is influenced by several factors, including its polarity and molecular structure. Understanding these properties helps predict how this compound interacts in various solvents.

Solubility Characteristics

Key factors affecting the solubility of this compound include:

  • Polarity: The presence of an amine group and methoxy substituent contributes to certain polar characteristics, which may improve solubility in polar solvents like water and alcohols.
  • Molecular Weight: With a moderate molecular weight of 312 g/mol, there may be a balance between solubility and structural complexity.
  • Intermolecular Interactions: The compound can potentially engage in hydrogen bonding due to the amine and methoxy groups, further influencing its solubility profile.

Solvent Compatibility

When considering solvent compatibility, it is important to note:

  • This compound is likely to be more soluble in organic solvents such as ethanol and dichloromethane due to its hydrophobic phenothiazine core.
  • In contrast, solubility in water might be lower but is enhanced when contacting alcohols.

In conclusion, while detailed experimental data is essential for specifying quantitative solubility values, the factors outlined indicate a potential for this compound to exhibit varied solubility across different solvents, making it of interest in both pharmacological and chemical research contexts.

Interesting facts

3-(2-methoxyphenothiazin-10-yl)-N,N,2-trimethyl-propan-1-amine

This compound, often referred to for its complex structure, features a unique combination of a phenothiazine moiety and a trimethylamine group, making it a fascinating subject of study in both medicinal chemistry and pharmacology.

Interesting Attributes

  • Pharmacological Potential: The presence of the phenothiazine structure suggests potential applications in treating mental health disorders, as many phenothiazine derivatives have been historically used as antipsychotic medications. This compound might exhibit similar properties worth exploring.
  • Structural Complexity: The combination of a bulky trimethyl group and a versatile methoxy substitution can lead to interesting steric effects, potentially influencing the compound's interactions with biological targets.
  • Synthesis Pathways: The synthetic routes to create this compound involve intricate steps and careful manipulation of reactive groups. This presents an excellent opportunity for chemistry students to delve into organic synthesis techniques.
  • Studied Mechanisms: Understanding the mechanism of action could open doors to insights about how such compounds affect neurotransmitter systems, particularly those involving dopamine and serotonin.

In the words of Richard Feynman, "The beauty of a flower is not in the mechanics of photo-synthesis... but the exquisite architecture of the flower itself." Similarly, this compound's significance lies not just in its predictive pharmacological properties, but also in the intricate arrangement of its molecular architecture, hinting at further undiscovered properties and derivatives.

Overall, 3-(2-methoxyphenothiazin-10-yl)-N,N,2-trimethyl-propan-1-amine represents an exciting junction in modern chemistry and potentially holds the key to advancing our understanding of therapeutic strategies in medicine.

Synonyms
851-68-3
rac Methotrimeprazine
Levopromazine
2-Methoxy-N,N,beta-trimethyl-10H-phenothiazine-10-propylamine
DL-Levomepromazine
dl-Methotrimeprazine
( inverted exclamation markA)-Levomepromazine
3-(2-methoxyphenothiazin-10-yl)-N,N,2-trimethylpropan-1-amine
10H-Phenothiazine-10-propanamine, 2-methoxy-N,N,.beta.-trimethyl-
Phenothiazine, 10-[3-(dimethylamino)-2-methylpropyl]-2-methoxy-
(+/-)-Methotrimeprazine
NSC226516
10-[3-(Dimethylamino)-2-methylpropyl]-2-methoxyphenothiazine; (+/-)-2-Methoxy-10-[3-(dimethylamino)-2-methylpropyl]phenothiazine; (+/-)-Methotrimeprazine; 10-[3-(Dimethylamino)-2-methylpropyl]-2-methoxyphenothiazine; dl-Methotrimeprazine
EINECS 212-706-8
Phenothiazine, (-)-
Oprea1_611208
(.+/-.)-Methotrimeprazine
CHEMBL22987
SCHEMBL6944555
DTXSID50859045
VRQVVMDWGGWHTJ-UHFFFAOYSA-N
PXB80551
AKOS004908120
DA-49438
HY-19489
MS-24928
CS-0015587
NS00004047
L000851
phenothiazine, 10-(2-dimethylaminomethyl)propyl-2-methoxy-
10-(3-(Dimethylamino)-2-methylpropyl)-2-methoxyphenothiazine
10-[3-Dimethylamino-2-methyl-propyl]-2-methoxy-phenothiazin
10H-Phenothiazine-10-propanamine,N,.beta.-trimethyl-, (-)-
2-Methoxy-N,N,.beta.-trimethyl-10H-phenothiazine-10-propylamine
10H-Phenothiazine-10-propanamine, 2-methoxy-N,N,.beta.-trimethyl-, (-)-
3-(2-Methoxy-10H-phenothiazin-10-yl)-N,N,2-trimethyl-1-propanamine #
3-(2-Methoxy-10H-phenothiazin-10-yl)-N,N,2-trimethylpropan-1-amine