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3-(2-Pyridylmethyl)-1H-indole

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Identification
Molecular formula
C14H12N2
CAS number
15170-97-9
IUPAC name
3-(2-pyridylmethyl)-1H-indole
State
State

At room temperature, 3-(2-Pyridylmethyl)-1H-indole is in a solid state. It is relatively stable under standard conditions but should be protected from excessive moisture and light to prevent degradation or reaction.

Melting point (Celsius)
192.00
Melting point (Kelvin)
465.15
Boiling point (Celsius)
291.00
Boiling point (Kelvin)
564.15
General information
Molecular weight
220.27g/mol
Molar mass
220.2720g/mol
Density
1.2500g/cm3
Appearence

3-(2-Pyridylmethyl)-1H-indole is typically a solid compound. It may present as a crystalline powder. The exact color and texture can vary slightly depending on impurities and specific conditions of crystallization. Its appearance is otherwise consistent with many heterocyclic aromatic compounds, often presenting as a pale, off-white to light yellow solid when pure.

Comment on solubility

Solubility of 3-(2-pyridylmethyl)-1H-indole

The solubility of 3-(2-pyridylmethyl)-1H-indole can be particularly intriguing due to its complex structure and the presence of multiple functional groups. Factors affecting its solubility include:

  • Polarity: The presence of the pyridine ring may enhance polar interactions, affecting solubility in polar solvents.
  • Hydrophobic Interactions: The indole component contributes hydrophobic character, which might promote solubility in non-polar environments.
  • Functional Group Interactions: Functional groups can engage in hydrogen bonding, influencing solubility in various solvents.
  • Solvent Choice: This compound may show differing solubility in solvents such as water, ethanol, or dichloromethane.

When considering its solubility, it is vital to note:

  1. The potential for low solubility in water due to its hydrophobic components.
  2. Greater solubility in organic solvents like ethanol, where its polar and non-polar characteristics can be effectively balanced.

In conclusion, the solubility of 3-(2-pyridylmethyl)-1H-indole is a nuanced topic influenced by its unique molecular structure. Understanding these characteristics can unlock insights into its behavior in various chemical environments.

Interesting facts

Introducing 3-(2-pyridylmethyl)-1H-indole

3-(2-pyridylmethyl)-1H-indole is a fascinating compound that sits at the intersection of medicinal chemistry and organic synthesis. This compound is a derivative of indole, a structure known for its presence in many natural products and pharmaceuticals.

Key Features of 3-(2-pyridylmethyl)-1H-indole

  • Structural Significance: The indole structure is a bicyclic compound containing a six-membered benzene ring fused to a five-membered nitrogen-containing pyrrole ring. This unique architecture contributes to the compound's biological activity.
  • Pharmacological Potential: Compounds that contain both indole and pyridine rings often exhibit a range of biological activities, including anti-inflammatory, antidepressant, and antitumor properties. Research has indicated that indole derivatives play an integral role in drug design.
  • Research Applications: The incorporation of a pyridylmethyl group can enhance the interaction between the compound and various biological targets, making it a subject of interest in the fields of pharmaceutical chemistry and medicinal research.

Interesting Tidbits

Here are some additional aspects that make 3-(2-pyridylmethyl)-1H-indole noteworthy:

  • The indole ring alone is found in various neurotransmitters, including serotonin, highlighting the potential relevance of its derivatives in neurochemical research.
  • Due to its unique properties, 3-(2-pyridylmethyl)-1H-indole serves as a versatile intermediate in organic synthesis, paving the way for further derivatization and functionalization.
  • Researchers are increasingly focused on modifying this compound to explore how slight changes to its structure can impact its biological activity.

As a compound representing both complexity and therapeutic promise, 3-(2-pyridylmethyl)-1H-indole showcases the intricate relationship between structure and function in the realm of chemistry. Its study presents ongoing challenges and opportunities for chemists aiming to unlock new compounds for medicinal use.

Synonyms
3-(2-Pyridylmethyl)indole
INDOLE, 3-(2-PYRIDYLMETHYL)-
BRN 0160898
5580-44-9
DTXSID60204385
DTXCID60126876
5-23-08-00523 (beilstein handbook reference)
SCHEMBL735576
3-Pyridin-2-ylmethyl-1H-indole
REMGZSGXONUDEF-UHFFFAOYSA-N