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Tacrine hydrochloride

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Identification
Molecular formula
C13H14N2O•HCl
CAS number
1684-40-8
IUPAC name
3-(2,3,4,4a,9,9a-hexahydro-1H-acridin-10-yl)propyl-dimethyl-ammonium;4-hydroxy-4-oxo-but-2-enoate
State
State

At room temperature, Tacrine hydrochloride is typically in a solid state as a crystalline powder.

Melting point (Celsius)
296.00
Melting point (Kelvin)
569.15
Boiling point (Celsius)
280.00
Boiling point (Kelvin)
553.15
General information
Molecular weight
398.91g/mol
Molar mass
398.9110g/mol
Density
1.2900g/cm3
Appearence

Tacrine hydrochloride is typically a white to off-white crystalline powder. It is hygroscopic, meaning it can absorb moisture from the environment, and is often available in a hydrated form.

Comment on solubility

Solubility of 3-(2,3,4,4a,9,9a-hexahydro-1H-acridin-10-yl)propyl-dimethyl-ammonium; 4-hydroxy-4-oxo-but-2-enoate

The solubility of 3-(2,3,4,4a,9,9a-hexahydro-1H-acridin-10-yl)propyl-dimethyl-ammonium; 4-hydroxy-4-oxo-but-2-enoate can be quite complex due to its structural characteristics. Here are some key points to consider:

  • Ionic vs. Non-Ionic: The presence of the ammonium group suggests that this compound may exhibit ionic characteristics, which often enhances water solubility.
  • Polar Functional Groups: The hydroxyl group (-OH) in the 4-hydroxy-4-oxo-but-2-enoate component contributes to polarity, typically increasing solubility in polar solvents like water.
  • Hydrophobic Regions: The acridine moiety may introduce some hydrophobic characteristics, potentially reducing solubility in polar solvents.
  • Solvent Considerations: This compound could be more soluble in certain organic solvents, especially if they are able to interact favorably with its hydrophobic regions.

In summary, while the compound may display a degree of solubility in polar solvents due to its ionic and polar features, the presence of hydrophobic elements must be taken into account. As stated, "The balance between hydrophilic and hydrophobic characteristics ultimately dictates solubility." Experimental data would be essential to accurately determine its solubility profile across various solvents.

Interesting facts

Interesting Facts about 3-(2,3,4,4a,9,9a-hexahydro-1H-acridin-10-yl)propyl-dimethyl-ammonium; 4-hydroxy-4-oxo-but-2-enoate

This fascinating compound showcases the intriguing intersection of organic chemistry and pharmacology. As a quaternary ammonium compound, it incorporates both a dimethylammonium group and a unique acyclic structure derived from acridine, giving it potential biological significance. Here are some engaging facts about this compound:

  • Biological Relevance: Compounds in the family of acridine derivatives are often studied for their antibacterial and antiviral properties, suggesting potential therapeutic applications.
  • Synthetic Insights: The synthesis of such compounds can challenge chemists due to the complexity of integrating alkyl chains and heterocycles, making them vital subjects in organic synthesis courses.
  • Reaction Intermediates: The presence of the 4-hydroxy-4-oxo-but-2-enoate moiety hints at its role as an intermediate in various organic reactions, especially in the context of forming more complex molecules.
  • Polymeric Applications: Investigating the polymerization behavior of such compounds may reveal innovative materials with unique properties due to their charged characteristic.
  • Research Potential: Its structural complexity makes it an attractive candidate for further research in medicinal chemistry, particularly in developing new drugs that target specific biological pathways.

As this compound is explored further, it offers a gateway into understanding the multifaceted roles that complex organic molecules can play in both nature and synthetic applications, proving that chemistry is always pushing the boundaries of what is possible!