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Azatadine

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Identification
Molecular formula
C20H24Cl2N2O
CAS number
3964-81-2
IUPAC name
3-[(2,4-dichloro-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-yl)oxy]-N,N-dimethyl-propan-1-amine
State
State

In its pure form, azatadine is a solid at room temperature.

Melting point (Celsius)
95.00
Melting point (Kelvin)
368.15
Boiling point (Celsius)
431.60
Boiling point (Kelvin)
704.75
General information
Molecular weight
325.22g/mol
Molar mass
325.2170g/mol
Density
1.2700g/cm3
Appearence

Azatadine typically appears as a white to off-white crystalline powder. It is usually provided in the form of tablets for pharmaceutical applications.

Comment on solubility

Solubility Characteristics of 3-[(2,4-dichloro-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-yl)oxy]-N,N-dimethyl-propan-1-amine

The solubility of this compound, known for its intricate molecular structure, can be influenced by various factors. Understanding its solubility is crucial for applications in pharmaceuticals and chemical research. Below are key points regarding its solubility:

  • Polarity: The presence of the polar amine functional group may enhance solubility in polar solvents, whereas the aromatic and cycloaliphatic structures may favor solubility in non-polar solvents.
  • Temperature Dependence: Like many organic compounds, solubility is likely to increase with temperature. As temperature rises, kinetic energy increases, potentially enabling better solvation.
  • Solvent Interaction: This compound may be soluble in solvents such as ethanol, methanol, or DMSO, which can stabilize interactions with its polar functional groups.
  • pH Influence: Variations in pH can also affect the ionization of the amine group, which could lead to increased solubility in aqueous solutions under certain conditions.

In conclusion, the solubility of this compound is a complex interplay of factors, mainly driven by polarity and interaction with solvents. Further experimental studies could provide valuable insights into its solubility properties, guiding effective applications in relevant fields.

Interesting facts

Interesting Facts about 3-[(2,4-dichloro-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-yl)oxy]-N,N-dimethyl-propan-1-amine

This remarkable compound, a derivative of quinoline, features a unique molecular structure that exhibits a range of interesting properties. Here are some captivating insights into this compound:

  • Pharmacological Potential: The compound is extensively studied for its potential therapeutic applications, particularly in the field of neuroscience. Its structure allows it to interact with various neurotransmitter systems, offering promise in treating conditions like depression and anxiety.
  • Chlorine Atoms: The presence of chlorine atoms in its structure not only enhances its biological activity but also contributes to its lipophilicity, which affects how the compound interacts within biological systems.
  • Cyclic Structure: The cycloheptamine moiety introduces a rigid conformation that may influence how the compound interacts with its target receptors, making it an intriguing subject for medicinal chemistry research.
  • Dimethylamino Group: The N,N-dimethylamino functional group can increase the molecule's basicity, potentially impacting its pharmacodynamics and pharmacokinetics, which are critical factors in drug design.
  • Research Implications: Ongoing studies may focus on the modification of this compound to enhance selectivity and reduce side effects, a common strategy in medicinal chemistry.

As scientists explore the myriad interactions of this compound, they continue to delve deeper into its mechanisms of action and potential for clinical applications. The fascinating interplay between its structure and biological effects highlights the importance of chemical diversity in the development of new therapeutic agents.

Synonyms
18833-64-2
BRN 1491784
6H-Cyclohepta(b)quinoline, 2,4-dichloro-11-(3-(dimethylamino)propoxy)-7,8,9,10-tetrahydro-
DTXSID30172183
2,4-Dichloro-11-(3-(dimethylamino)propoxy)-7,8,9,10-tetrahydro-6H-cyclohepta(b)quinoline
2,4-Dichloro-11-[3-(dimethylamino)propoxy]-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinoline
DTXCID3094674
5-21-03-00530 (Beilstein Handbook Reference)
3-[(2,4-dichloro-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-yl)oxy]-N,N-dimethylpropan-1-amine