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Rifampicin

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Identification
Molecular formula
C43H58N4O12
CAS number
13292-46-1
IUPAC name
3-[2,6-dimethyl-5-[(6-methyl-5-oxo-2H-pyran-2-yl)oxy]tetrahydropyran-2-yl]oxy-9-[5-[2,6-dimethyl-5-[(6-methyl-5-oxo-2H-pyran-2-yl)oxy]tetrahydropyran-2-yl]oxy-4-hydroxy-6-methyl-tetrahydropyran-2-yl]-4a,12b-dihydroxy-3-methyl-2,4-dihydrobenzo[a]anthracene-1,7,12-trione
State
State

Rifampicin is typically found in a solid state at room temperature. It is formulated as a crystalline powder when used in laboratory and medicinal preparations.

Melting point (Celsius)
183.00
Melting point (Kelvin)
456.15
Boiling point (Celsius)
540.00
Boiling point (Kelvin)
813.15
General information
Molecular weight
822.94g/mol
Molar mass
822.9450g/mol
Density
1.3000g/cm3
Appearence

Rifampicin is an orange-red solid that may appear as a red-brown or red-violet crystalline powder. It is known for its bright pigmentation and may impart a characteristic reddish color when dissolved or added to other substances.

Comment on solubility

Solubility of 3-[2,6-dimethyl-5-[(6-methyl-5-oxo-2H-pyran-2-yl)oxy]tetrahydropyran-2-yl]oxy-9-[5-[2,6-dimethyl-5-[(6-methyl-5-oxo-2H-pyran-2-yl)oxy]tetrahydropyran-2-yl]oxy-4-hydroxy-6-methyl-tetrahydropyran-2-yl]-4a,12b-dihydroxy-3-methyl-2,4-dihydrobenzo[a]anthracene-1,7,12-trione

The solubility of this complex compound, C43H58N4O12, is influenced by various structural characteristics. Here are some important points to consider regarding its solubility:

  • Polarity: The presence of polar functional groups may enhance solubility in polar solvents, while larger non-polar hydrocarbon segments could promote solubility in organic solvents.
  • Hydrogen Bonding: The hydroxyl groups in the molecule facilitate hydrogen bonding with water, potentially increasing aqueous solubility.
  • Solvent Interaction: Depending on the solvent used, solubility may vary dramatically. For instance, solubility in methanol or ethanol could differ from that in DMSO or acetone.

In summary, the solubility of this compound is likely to be modest in water due to its bulky structure, while showing greater solubility in organic solvents. This highlights the importance of choosing the right solvent for effective application in chemical processes.

Interesting facts

Interesting Facts About 3-[2,6-Dimethyl-5-[(6-Methyl-5-Oxo-2H-Pyran-2-Yl)Oxy]Tetrahydropyran-2-Yl]Oxy-9-[5-[2,6-Dimethyl-5-[(6-Methyl-5-Oxo-2H-Pyran-2-Yl)Oxy]Tetrahydropyran-2-Yl]Oxy-4-Hydroxy-6-Methyl-Tetrahydropyran-2-Yl]-4A,12B-Dihydroxy-3-Methyl-2,4-Dihydrobenzo[a]anthracene-1,7,12-Trione

This remarkable compound boasts an intricate structure that reflects a rich tapestry of molecular interactions. Here are some intriguing aspects of this compound:

  • Complexity: This molecule is recognized for its elaborate arrangement, featuring multiple substituents like dimethyl and hydroxy groups, alongside various heterocycles such as pyrans and tetrahydropyrans.
  • Biological Interest: Compounds of this nature often showcase promising biological activities, leading to interest in their potential as therapeutics. Research in this area could unveil applications in medicine, particularly in cancer treatment.
  • Natural Product Derivation: The presence of pyran-based entities suggests that the compound may be inspired by or derived from natural products, further hinting at its significance in organic synthesis and medicinal chemistry.
  • Structure-Activity Relationship (SAR): Understanding how various structural elements of this compound influence biological activity could lead to the development of new drugs with enhanced efficacy and reduced side effects.
  • Chemical Interactions: The integration of multiple functional groups enriches the scope of potential intermolecular interactions, making this compound a fascinating subject for studies in reactivity and stability.

As scientists delve deeper into the mechanisms and properties of such compounds, they may uncover new pathways to harnessing their potential. The journey of understanding and utilizing 3-[2,6-Dimethyl-5-[(6-Methyl-5-Oxo-2H-Pyran-2-Yl)Oxy]Tetrahydropyran-2-Yl]Oxy-9-[...] could lead to breakthroughs in various scientific fields, making it a compound worth studying.