Skip to main content

Clomipramine

ADVERTISEMENT
Identification
Molecular formula
C19H23ClN2S
CAS number
303-49-1
IUPAC name
3-(2,9-dichloro-6,11-dihydrobenzo[c][1]benzothiepin-11-yl)-N,N-dimethyl-propan-1-amine
State
State

At room temperature, clomipramine is in a solid state, typically found in its hydrochloride salt form for pharmaceutical use.

Melting point (Celsius)
189.00
Melting point (Kelvin)
462.15
Boiling point (Celsius)
415.10
Boiling point (Kelvin)
688.30
General information
Molecular weight
314.86g/mol
Molar mass
314.2570g/mol
Density
1.2000g/cm3
Appearence

Clomipramine is generally seen as a white to off-white crystalline powder. The compound is known for being odorless and has a bitter taste.

Comment on solubility

Solubility of 3-(2,9-dichloro-6,11-dihydrobenzo[1]benzothiepin-11-yl)-N,N-dimethyl-propan-1-amine

The solubility of the compound 3-(2,9-dichloro-6,11-dihydrobenzo[1]benzothiepin-11-yl)-N,N-dimethyl-propan-1-amine can be influenced by several factors:

  • Polar vs. Nonpolar: This compound exhibits a complex molecular structure that includes both polar and nonpolar components. Typically, nonpolar compounds may have limited solubility in polar solvents like water.
  • Amine Functionality: The presence of the dimethylaminopropane portion suggests potential for increased solubility in polar solvents due to the amine's ability to engage in hydrogen bonding.
  • Chlorination Effects: The dichlorinated aromatic system may further impact solubility, as halogens can alter hydrophobic characteristics, complicating interactions with various solvents.

In summary, the solubility behaviors of this compound are likely varied and complex. While it may demonstrate some degree of solubility in polar solvents due to the amine group, its overall solubility profile would require experimental determination for a more accurate depiction.

Interesting facts

Interesting Facts about 3-(2,9-Dichloro-6,11-dihydrobenzo[c][1]benzothiepin-11-yl)-N,N-dimethyl-propan-1-amine

This compound represents an intriguing class of chemical entities known as benzo[c][1]benzothiepins, which are notable for their diverse biological activities and potential therapeutic applications. Here are some interesting highlights about this compound:

  • Structural Complexity: The structure of this compound is emblematic of complex organic chemistry, showcasing multiple aromatic rings fused together, which often contributes to unique reactivity and interaction patterns with biological targets.
  • Biological Significance: Compounds like this one have been studied for their potential pharmacological activities, including their role in neurotransmitter modulation and possible applications as antidepressants or antipsychotics.
  • Chlorine Substitution: The presence of chlorine atoms can significantly impact the compound's chemical properties, such as its lipophilicity and overall stability, influencing how it interacts in biological systems.
  • Dimethylamino Group: The N,N-dimethyl-propan-1-amine moiety adds basicity to the compound, potentially enhancing its ability to penetrate lipid membranes and reach intracellular targets.

The synthesis and study of such compounds not only enhance our understanding of organic synthesis but also pave the way for innovative drug design. As the field of medicinal chemistry continues to evolve, exploring molecules like this can lead to groundbreaking treatments for various diseases. As one famous chemist once said, "Chemistry is the art of transformation." Each compound offers a new opportunity for transformation and discovery!