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Prazosin

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Identification
Molecular formula
C19H21ClN4O2
CAS number
19216-56-9
IUPAC name
3-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-1H-quinazoline-2,4-dione
State
State

At room temperature, Prazosin is in a solid state, typically encountered as a powder.

Melting point (Celsius)
245.00
Melting point (Kelvin)
518.20
Boiling point (Celsius)
847.15
Boiling point (Kelvin)
1 120.30
General information
Molecular weight
383.86g/mol
Molar mass
383.8690g/mol
Density
1.5000g/cm3
Appearence

Prazosin is typically encountered as a white to almost white, crystalline powder. It is often supplied in its hydrochloride salt form for pharmaceutical use, attributing to better solubility and stability.

Comment on solubility

Solubility of 3-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-1H-quinazoline-2,4-dione

The solubility of 3-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-1H-quinazoline-2,4-dione can be influenced by several factors, including its molecular structure and the nature of its interactions with solvents. Here are some key points to consider:

  • Polar vs. Non-Polar Solvents: The compound contains both polar and non-polar characteristics, which suggests it may have variable solubility in different solvent environments. This dual nature could allow for solubility in both water and organic solvents.
  • Temperature Dependence: Solubility is often temperature-dependent. Typically, increased temperature will enhance solubility, especially for solid compounds.
  • pH Influences: The pH of the solution can significantly affect the ionization state of the molecule, possibly improving solubility in basic or acidic conditions.
  • Crystallinity: If the compound has a high degree of crystallinity, it may exhibit lower solubility due to the energy required to break the crystal lattice.

In summary, the solubility of 3-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-1H-quinazoline-2,4-dione is likely to be moderate in suitable solvents, and can be further examined through experimental studies to determine precise solubility values in different conditions.

Interesting facts

Interesting Facts About 3-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-1H-quinazoline-2,4-dione

This compound, often studied in medicinal chemistry, holds significant potential in the realm of pharmacology. Here are some fascinating aspects to consider:

  • Pharmacological Applications: Compounds like this one are often evaluated for their role as antidepressants or antipsychotics. Their structural characteristics enable them to interact effectively with various neurotransmitter receptors in the brain, which is crucial for mood regulation.
  • Structural Complexity: The compound features a unique combination of a quinazoline core fused with piperazine and chlorophenyl groups. This diversity can lead to interesting electronic and steric effects, impacting its biological activity.
  • Chirality and Isomerism: The presence of piperazine in the molecule introduces potential for stereoisomerism. Chirality can greatly influence the pharmacokinetics and dynamics of the compound, affecting how it behaves in the body.
  • Target Identification: Understanding the interactions of such compounds with specific targets in the body is essential for drug development. Research often focuses on how they bind to various receptor sites, which can lead to discoveries of new therapeutic agents.
  • Research Highlights: Recent studies may showcase this compound's efficacy in clinical models, contributing valuable insights into treating neurological disorders. As researchers explore its mechanisms, they often discover novel pathways and interactions.

Overall, 3-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-1H-quinazoline-2,4-dione is not just a chemical formula; it represents a potential breakthrough in understanding and treating complex mental health conditions. The delicate interplay of its structural components and their resultant biological implications make it a compelling subject of study.

Synonyms
Cloperidone
Cloperidona
4052-13-5
Cloperidone [INN]
Cloperidonum
UNII-8FP5Y6U39R
8FP5Y6U39R
CLOPERIDONE [WHO-DD]
DTXSID30193530
3-(3-(4-m-Chlorophenyl)-1-piperazinyl)propyl)-2,4(1H,3H)-quinazolinedione
2,4(1H,3H)-QUINAZOLINEDIONE, 3-(3-(4-(3-CHLOROPHENYL)-1-PIPERAZINYL)PROPYL)-
3-(3-(4-(M-CHLOROPHENYL)-1-PIPERAZINYL)PROPYL)-2,4-(1H,3H)-QUINAZOLINEDIONE
2,4(1H,3H)-Quinazolinedione,3-(3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)-
2,4(1H,3H)-Quinazolinedione,3-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-
DTXCID70116021
3-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-1H-quinazoline-2,4-dione
NSC198100
SR-01000945162
Cloperidone (USAN)
MA1337 (Hydrochloride)
MLS006011539
CHEMBL2110792
AKOS033109858
SMR004703306
HY-164031
CS-1097762
NS00121502
EN300-7529309
SR-01000945162-1
SR-01000945162-2
Q27270347
Z1147555087
3-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-1,2,3,4-tetrahydroquinazoline-2,4-dione
2,4(1H,3H)-Quinazolinedione,3-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-,monohydrochloride
2,4(1H,3H)-Quinazolinedione,3-[3-[4-(m-chlorophenyl)-1-piperazinyl]propyl]-,monohydrochloride (8CI)
3-[3-[4-(m-Chlorophenyl)-1-piperazinyl]propyl]-2,4(1H,3H)-quinazolinedionemonohydrochloride