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Quetiapine

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Identification
Molecular formula
C21H25ClN2O2
CAS number
111974-69-7
IUPAC name
3-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-1H-quinazoline-2,4-dione;hydrochloride
State
State

In its pure form, Quetiapine is a solid at room temperature, generally supplied as a tablet or capsule for oral administration.

Melting point (Celsius)
170.50
Melting point (Kelvin)
443.65
Boiling point (Celsius)
743.20
Boiling point (Kelvin)
1 016.35
General information
Molecular weight
383.87g/mol
Molar mass
383.8710g/mol
Density
1.3712g/cm3
Appearence

Quetiapine, in its pure form, appears as a white to off-white crystalline powder. It's often formulated into tablet form for pharmaceutical use.

Comment on solubility

Solubility of 3-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-1H-quinazoline-2,4-dione; hydrochloride

The solubility of this compound, 3-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-1H-quinazoline-2,4-dione; hydrochloride, can be influenced by several factors such as pH, solvent type, and temperature. Here’s a breakdown of its solubility characteristics:

  • pH Sensitivity: The hydrochloride salt form often exhibits good solubility in aqueous solutions, particularly at acidic pH levels due to protonation.
  • Solvent Compatibility: It tends to dissolve well in polar solvents. For instance, it may show a higher solubility in water and ethanol than in nonpolar solvents.
  • Temperature Effects: Increasing the temperature may enhance solubility, allowing greater dissolution of the compound in solution.

It is important to consider the following points:

  • ***"Hydrochloride salts typically increase solubility in aqueous solutions, making this compound potentially bioavailable in drug formulations."***
  • Polarity: The presence of chlorine and the piperazine group may enhance interactions with solvents, further impacting solubility.

In summary, the solubility of this hydrochloride compound is likely favorable in acidic and polar environments, which can be advantageous for pharmaceutical applications.

Interesting facts

Interesting Facts about 3-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-1H-quinazoline-2,4-dione;hydrochloride

The compound 3-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-1H-quinazoline-2,4-dione;hydrochloride, commonly referred to as a pharmaceutical compound, showcases the intricate relationship between chemical structure and biological activity. This compound is often studied for its potential pharmaceutical applications, particularly in the field of neurological disorders and mood enhancement. Here are some intriguing aspects:

  • Design and Structure: The structure of this compound features a quinazoline core, renowned for its diverse biological activities. The combination of the piperazine ring and the chlorophenyl moiety allows for enhanced receptor interaction.
  • Pharmacological Interest: Research has indicated that compounds featuring similar structures may exhibit antipsychotic, anxiolytic, and anti-depressant properties, which can be attributed to their influence on serotonergic and dopaminergic systems.
  • Signal Transduction: Investigating how this compound interacts with specific neurotransmitter receptors provides insight into its mechanism of action, potentially leading to better treatments for mood disorders.
  • Therapeutic Potential: Studies are ongoing to explore its use in clinical settings, especially concerning its efficacy and safety profile, which could open doors to novel approaches in therapy.

As researchers continue to explore this compound, it exemplifies how modifications at the molecular level can lead to significant changes in pharmacological activity. The journey of understanding and developing such compounds not only advances medicinal chemistry but also fosters hope for innovative treatments in psychiatry.

In the words of a notable chemist, "The beauty of chemistry lies in the bonds we create, not just between atoms, but in our pursuit of knowledge." This compound serves as a perfect illustration of that pursuit.

Synonyms
CLOPERIDONE HYDROCHLORIDE
Cloperidone HCl
525-26-8
MA 1337
Cloperidone hydrochloride [USAN]
NSC 198100
NSC-198100
UNII-17682058OP
MA-1337
17682058OP
Cloperidone hydrochloride (USAN)
DTXSID20200500
2,4(1H,3H)-Quinazolinedione, 3-(3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)-, monohydrochloride
3-(3-(4-(m-Chlorophenyl)-1-piperazinyl)propyl)-2,4(1H,3H)-quinazolinedione hydrochloride
3-(3-(4-(m-Chlorophenyl)-1-piperazinyl)propyl)-2,4-(1H,3H)-quinazolinedione monohydrochloride
DTXCID80122991
3-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-1H-quinazoline-2,4-dione;hydrochloride
2,4(1H,3H)-Quinazolinedione,3-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-, hydrochloride (1:1)
NSC198100
SCHEMBL122569
CHEMBL2106069
D03558
EN300-19788549
Q27251877
2,3H)-Quinazolinedione, 3-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-, monohydrochloride
2,3H)-Quinazolinedione, 3-[3-[4-(m-chlorophenyl)-1-piperazinyl]propyl]-, monohydrochloride
3-[3-[4-(m-Chlorophenyl)-1-piperazinyl]propyl]-2,3H)-quinazolinedione monohydrochloride
3-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-1,2,3,4-tetrahydroquinazoline-2,4-dione hydrochloride