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Cariprazine

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Identification
Molecular formula
C21H32N4O
CAS number
839712-12-8
IUPAC name
3-[3-(4-benzhydrylpiperazin-1-yl)propyl]-1H-benzimidazol-2-one
State
State

Cariprazine is found in its solid form at room temperature, usually as part of a medicinal compound in capsules or tablets for oral administration.

Melting point (Celsius)
174.00
Melting point (Kelvin)
447.15
Boiling point (Celsius)
524.50
Boiling point (Kelvin)
797.65
General information
Molecular weight
427.99g/mol
Molar mass
427.9930g/mol
Density
1.2450g/cm3
Appearence

Cariprazine is typically a white to off-white crystalline powder. It is not usually encountered in its pure form by consumers as it is prepared in pharmaceutical formulations.

Comment on solubility

Solubility of 3-[3-(4-benzhydrylpiperazin-1-yl)propyl]-1H-benzimidazol-2-one

The solubility of 3-[3-(4-benzhydrylpiperazin-1-yl)propyl]-1H-benzimidazol-2-one (C21H32N4O) is influenced by several factors, including its molecular structure and functional groups. Here are the key aspects to consider:

  • Polar vs Nonpolar: This compound features a mix of polar and nonpolar regions, which can help in solubilizing in a variety of solvents.
  • Typical Solvents: It is likely to exhibit solubility in organic solvents such as:
    • Dimethyl sulfoxide (DMSO)
    • Dimethylformamide (DMF)
    • Acetonitrile
  • Water Solubility: The introduction of piperazine likely enhances solubility in water to a certain extent due to hydrogen bonding, though complete solubility may not be achieved.
  • Temperature Dependence: It's essential to consider that solubility can vary significantly with temperature, typically increasing in warmer conditions.
  • pH Influence: The solubility may also be affected by pH, particularly if the benzimidazole moiety can undergo protonation in acidic conditions.

In conclusion, while 3-[3-(4-benzhydrylpiperazin-1-yl)propyl]-1H-benzimidazol-2-one exhibits potential for solubility in various solvents, understanding the specific conditions and interactions is crucial for optimizing its use in formulations.

Interesting facts

Interesting Facts about 3-[3-(4-benzhydrylpiperazin-1-yl)propyl]-1H-benzimidazol-2-one

This compound is a fascinating member of the benzimidazole family, known for its diverse biological activities and therapeutic potential. Here are some noteworthy points that highlight its significance:

  • Pharmacological Potential: Compounds like this one often exhibit significant biological activity, making them targets for drug discovery. They may function as antidepressants or antipsychotic agents, impacting neurotransmitter pathways in the brain.
  • Structure-Activity Relationships: The distinct structural components, such as the piperazine and benzimidazole motifs, allow chemists to explore how variations can influence biological activity and efficacy. This is critical in medicinal chemistry for optimizing drug candidates.
  • Diverse Applications: Beyond potential CNS activities, compounds with such structures have been explored for their roles in oncology and antimicrobial applications, reflecting the broad spectrum of their activity.
  • Research Opportunities: The compound serves as a platform for further research, where modifying substituents can lead to the discovery of novel agents. Investigating these modifications can provide insights into the mechanisms of action and therapeutic benefits.

As Benjamin Franklin once said, "An investment in knowledge always pays the best interest." This statement rings true in the field of chemistry, especially with compounds like 3-[3-(4-benzhydrylpiperazin-1-yl)propyl]-1H-benzimidazol-2-one, where continued research could lead to groundbreaking discoveries that enhance our understanding of complex biological systems.

In summary, this compound embodies the intersection of synthetic chemistry and pharmacology, exemplifying how a single molecular structure can lead to vast implications in human health and disease management.

Synonyms
oxatomide
60607-34-3
Tinset
Celtect
Oxatimide
Oxatomida
Oxatomidum
Oxetal
Cobiona
Dasten
KW-4354
Oxatomidum [INN-Latin]
Oxatomida [INN-Spanish]
McN-JR 35443
Celtect (TN)
3-[3-(4-benzhydrylpiperazin-1-yl)propyl]-1H-benzimidazol-2-one
R 35443
R-35443
1-[3-[4-(Diphenylmethyl)-1-piperazinyl]propyl]-1,3-dihydro-2H-benzimidazol-2-one
R 35,443
EINECS 262-320-9
J31IL9Z2EE
1-(3-(4-Benzhydrylpiperazin-1-yl)propyl)-1H-benzo[d]imidazol-2(3H)-one
NSC-309710
BRN 4724760
DTXSID4045181
Oxatomide [USAN:INN:BAN:JAN]
OXATOMIDE [INN]
OXATOMIDE [JAN]
OXATOMIDE [MI]
OXATOMIDE [USAN]
OXATOMIDE [MART.]
OXATOMIDE [WHO-DD]
1-(3-(4-(Diphenylmethyl)-1-piperazinyl)propyl)-2-benzimidazolinone
1-(3-(4-(Diphenylmethyl)-1-piperazinyl)propyl)-1,3-dihydro-2H-benzimidazol-2-one
MLS000028549
DTXCID2025181
CHEBI:31943
1-[3-[4-(Diphenylmethyl)-1-piperazinyl]propyl]-2-benzimidazolinone
2H-Benzimidazol-2-one, 1-(3-(4-(diphenylmethyl)-1-piperazinyl)propyl)-1,3-dihydro-
NSC 309710
NCGC00015774-03
SMR000058301
Oxatomidum (INN-Latin)
Oxatomida (INN-Spanish)
OXATOMIDE (MART.)
1-{3-[4-(diphenylmethyl)piperazin-1-yl]propyl}-2,3-dihydro-1H-1,3-benzodiazol-2-one
2H-Benzimidazol-2-one, 1,3-dihydro-1-(3-(4-(diphenylmethyl)-1-piperazinyl)propyl)-
celtomide
C27H30N4O
1-(3-(4-Benzhydrylpiperazin-1-yl)propyl)-1,3-dihydro-2H-benzo[d]imidazol-2-one
1-{3-[4-(diphenylmethyl)piperazin-1-yl]propyl}-1,3-dihydro-2h-benzimidazol-2-one
2H-Benzimidazol-2-one, 1-[3-[4-(diphenylmethyl)-1-piperazinyl]propyl]-1,3-dihydro-
CAS-60607-34-3
KW 4354
R35443
CBMicro_024634
UNII-J31IL9Z2EE
Cenacert
Oxatomide (JAN/USAN/INN)
1-(3-(4-(diphenylmethyl)piperazin-1-yl)propyl)-1,3-dihydro-2H-benzimidazol-2-one
1-(3-(4-(diphenylmethyl)piperazin-1-yl)propyl)-2,3-dihydro-1H-1,3-benzodiazol-2-one
1-{3-[4-(diphenylmethyl)-1-piperazinyl]propyl}-1,3-dihydro-2H-benzimidazol-2-one
MFCD00211147
Oxatomide (Standard)
Oxatomide, >=99%
Lopac-O-9387
O 9387
cid_4615
Lopac0_000924
Oprea1_338592
REGID_for_CID_4615
SCHEMBL28824
CHEMBL13828
R 35 443
BDBM76863
R06AE06
HMS2089N07
HMS2231H12
HMS3372K08
Tox21_110219
CCG-11811
NSC309710
NSC771641
AKOS000507212
Tox21_110219_1
AB04841
DB12877
FO26615
HY-123205R
KS-1375
NSC-771641
NCGC00015774-01
NCGC00015774-02
NCGC00015774-04
NCGC00015774-05
NCGC00015774-06
NCGC00094235-01
NCGC00094235-02
BIM-0024581.P001
DB-053668
HY-123205
CS-0081837
EU-0100924
NS00004457
D01773
F97990
SBI-0024581.0001
AB01227629-02
AE-641/00600058
EN300-25890425
SR-01000076051
Q2071515
SR-01000076051-1
BRD-K02079473-001-01-3
3-[3-(4-benzhydrylpiperazino)propyl]-1H-benzimidazol-2-one
3-[3-[4-(diphenylmethyl)-1-piperazinyl]propyl]-1H-benzimidazol-2-one
3-[3-[4-(diphenylmethyl)piperazin-1-yl]propyl]-1H-benzimidazol-2-one
1-{3-[4-(diphenylmethyl)-1-piperazinyl}-propyl}-1,3-dihydro-2H-benzimidazol-2-one
1{-[4-(diphenylmethyl)-1-piperzinyl]propyl}-1,3-dihydro-2H-benzimidazol-2-one
1-[3-[4-(Diphenylmethyl)-1-piperazinyl]propyl]-1,3-dihydro-2H-benzimidazol-2-one;R-35443;Celtect
262-320-9