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Almorexant

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Identification
Molecular formula
C22H31FN2O
CAS number
871224-64-5
IUPAC name
3-[3-(4-fluorophenoxy)propyl]-3-azaspiro[5.5]undecane
State
State

Almorexant is typically in a solid state at room temperature.

Melting point (Celsius)
112.00
Melting point (Kelvin)
385.20
Boiling point (Celsius)
682.50
Boiling point (Kelvin)
955.70
General information
Molecular weight
429.49g/mol
Molar mass
429.5800g/mol
Density
1.2445g/cm3
Appearence

Almorexant appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of 3-[3-(4-fluorophenoxy)propyl]-3-azaspiro[5.5]undecane

The solubility of 3-[3-(4-fluorophenoxy)propyl]-3-azaspiro[5.5]undecane in various solvents is a vital aspect to consider, especially in pharmaceutical applications. Its unique structural characteristics impart distinct solvation properties. Here are some important points regarding its solubility:

  • Solvent Dependence: The compound shows varied solubility in different solvents, usually being more soluble in organic solvents like ethanol and dimethyl sulfoxide (DMSO) compared to water.
  • Non-Polar Nature: Due to its azaspiro structure and fluorophenoxy substituent, the compound tends to be less soluble in polar solvents, aligning with the principle of "like dissolves like."
  • Temperature Effect: Solubility may increase with temperature, revealing more about the thermodynamic properties of the compound when dissolved.
  • Applications in Solutions: Its solubility characteristics make it suitable for use in topical formulations, where solvent choices can significantly impact drug delivery efficiency.

In summary, understanding the solubility of 3-[3-(4-fluorophenoxy)propyl]-3-azaspiro[5.5]undecane is essential for optimizing its use in various chemical and pharmaceutical applications. For effective usage, it is crucial to select the appropriate solvent that maximizes the compound's solubility while considering its unique chemical properties.

Interesting facts

Interesting Facts about 3-[3-(4-fluorophenoxy)propyl]-3-azaspiro[5.5]undecane

3-[3-(4-fluorophenoxy)propyl]-3-azaspiro[5.5]undecane is a fascinating compound with a unique structure and potential applications in the field of medicinal chemistry. Here are some engaging facts about this compound:

  • Spiral Innovation: The compound features an azaspiro structure, which is characterized by its spiro-connected rings. This unique architecture can lead to novel interactions within biological systems and offers a platform for drug design.
  • Functional Groups: The presence of the 4-fluorophenoxy group is particularly interesting. Fluorinated compounds often exhibit enhanced biological activity and polarity, which can improve pharmacokinetic properties such as bioavailability and membrane permeability.
  • Potential Therapeutics: Compounds like this are actively researched for their possible therapeutic effects. Scientists examine their ability to interact with various receptors in the body, which could lead to new medications for treating conditions ranging from anxiety to neurological disorders.
  • Structure-Activity Relationship (SAR): The intricate balance between the compound's functional groups and its overall structure makes it an exciting subject for SAR studies, which help chemists understand how the molecular design affects biological activity.
  • Synthetic Challenges: Synthesis of such complex molecules often poses significant challenges. Researchers must navigate multiple steps and optimize conditions to ensure a high yield of the desired compound, making it a prime candidate for advanced synthetic methodologies.

In conclusion, 3-[3-(4-fluorophenoxy)propyl]-3-azaspiro[5.5]undecane exemplifies the intersection of structure and function in chemical research. The ongoing studies of this compound may very well contribute to innovative therapeutic developments in the near future.

Synonyms
1231-67-0
BRN 1347934
3-AZASPIRO(5.5)UNDECANE, 3-(3-(p-FLUOROPHENOXY)PROPYL)-
3-(3-(p-Fluorophenoxy)propyl)-3-azaspiro(5.5)undecane
DTXSID20153865
3-[3-(p-Fluorophenoxy)propyl]-3-azaspiro[5.5]undecane
DTXCID8076356
3-[3-(4-fluorophenoxy)propyl]-3-azaspiro[5.5]undecane