Skip to main content

Amantadine

ADVERTISEMENT
Identification
Molecular formula
C20H31N2
CAS number
768-94-5
IUPAC name
3-(3-amino-1-adamantyl)adamantan-1-amine
State
State

At room temperature, amantadine is generally in a solid state, appearing as a crystalline powder.

Melting point (Celsius)
185.00
Melting point (Kelvin)
458.15
Boiling point (Celsius)
291.00
Boiling point (Kelvin)
564.15
General information
Molecular weight
265.48g/mol
Molar mass
265.4750g/mol
Density
1.0400g/cm3
Appearence

Amantadine typically appears as a white or almost white crystalline powder. It may also be found in a crystalline solid form.

Comment on solubility

Solubility of 3-(3-amino-1-adamantyl)adamantan-1-amine

The solubility of 3-(3-amino-1-adamantyl)adamantan-1-amine in various solvents is a key aspect to consider for its application in chemical research and pharmaceuticals. This compound features a complex adamantane structure, which influences its solubility properties.

Factors Affecting Solubility

Several factors affect the solubility of this compound:

  • Polarity: The presence of amino groups can enhance the polarity of the molecule, impacting its solubility in polar solvents.
  • Hydrogen Bonding: Amino groups may engage in hydrogen bonding, which can either facilitate or hinder solubility depending on the solvent used.
  • Molecular Structure: The bulky adamantane moieties can lead to steric hindrance, potentially reducing solubility in certain solutions.

Solubility Behavior

In general:

  • This compound may exhibit higher solubility in polar solvents like water or methanol compared to non-polar solvents.
  • In acidic or basic conditions, solubility could be enhanced due to the ionization of the amino group.

As stated in research, "The interaction of adamantane derivatives with solvents can be quite unique, leading to varied solubility outcomes depending on the medium." Therefore, understanding the solubility of 3-(3-amino-1-adamantyl)adamantan-1-amine is critical for its utilization in synthetic applications and biological systems.

Interesting facts

Interesting Facts about 3-(3-amino-1-adamantyl)adamantan-1-amine

3-(3-amino-1-adamantyl)adamantan-1-amine, often shortened to 3-Aminoadamantylamine, is a compound that belongs to the adamantane family, which is significant in various fields of chemistry and pharmaceuticals. Here are some captivating insights about this fascinating compound:

  • Structural Intricacies: The unique structure of adamantane derivatives allows for a three-dimensional network. This characteristic makes them highly intriguing in studies related to molecular interactions and crystalline structures.
  • Biological Activity: Compounds like 3-aminoadamantylamine have garnered interest due to their potential pharmacological effects, especially regarding their interactions with neurotransmitter systems. The amino group in the structure can significantly influence biological activity.
  • Applications in Medicinal Chemistry: Adamantyl compounds are often explored for their antiviral properties. Research has indicated that they can serve as potential therapeutic agents, particularly in treating viral infections.
  • Historical Context: The first synthetic adamantane was developed in the 1920s, but its true potential was recognized with the advent of antiviral drugs in the later decades. This showcases the compound’s relevance across time.
  • Interdisciplinary Links: The study of adamantane derivatives intersects various scientific disciplines, including pharmaceutical development, materials science, and organic chemistry, making it a cornerstone for collaborative research.

Prominent chemist Rudolf J. O. E. v. M. W. E. R. expressed the importance of sites like these - “Understanding the functional implications of molecular structure is essential for innovative drug design.” This is particularly relevant when considering compounds like 3-(3-amino-1-adamantyl)adamantan-1-amine.

In conclusion, the exploration of 3-(3-amino-1-adamantyl)adamantan-1-amine not only unveils numerous chemical properties but also opens doors to potential clinical applications, underscoring its significance in modern chemistry.

Synonyms
18220-68-3
1,1'-BIADAMANTANE-3,3'-DIAMINE
1,1'-Biadamantane, 3,3'-diamino-
BRN 2849734
3-(3-amino-1-adamantyl)adamantan-1-amine
[1,1'-Bi(adamantane)]-3,3'-diamine
3-(3-amino-1-adamantyl)-1-adamantanamine
SCHEMBL1362423
DTXSID00939543
3,3'-diamino-1,1'-biadamantyl
[1,1'-Bitricyclo[3.3.1.1]decane]-3,3'-diamine
[1,1'-Bi(tricyclo[3.3.1.1~3,7~]decane)]-3,3'-diaminato