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Ambroxol hydrochloride dihydrate

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Identification
Molecular formula
C17H28Cl3N3O2
CAS number
23828-92-4
IUPAC name
3-(3-benzyl-3,9-diazabicyclo[3.3.1]nonan-9-yl)-N,N-dimethyl-propan-1-amine;dihydrate;trihydrochloride
State
State

The compound is typically found in a solid state at room temperature.

Melting point (Celsius)
89.00
Melting point (Kelvin)
362.15
Boiling point (Celsius)
105.00
Boiling point (Kelvin)
378.15
General information
Molecular weight
414.82g/mol
Molar mass
414.8220g/mol
Density
1.2945g/cm3
Appearence

The compound typically appears as a white or almost white crystalline powder. It is often supplied in a hydrated form which contains water of crystallization.

Comment on solubility

Solubility of 3-(3-benzyl-3,9-diazabicyclo[3.3.1]nonan-9-yl)-N,N-dimethyl-propan-1-amine; dihydrate; trihydrochloride

This compound, with a complex structure, exhibits unique solubility characteristics that are essential to understand for its practical applications. The solubility of this compound can be influenced by several factors:

  • Polarity: The presence of multiple functional groups in the compound increases its polarity, enhancing its solubility in polar solvents such as water.
  • Hydrochloride Form: Being a trihydrochloride implies that it is a salt form, which typically increases solubility in aqueous solutions compared to its base form.
  • Dihydrate Nature: The dihydrate nature indicates that water molecules are integrated into the structure, possibly aiding in its dissolution.
  • Temperature Influence: Solubility may increase with temperature, making it particularly important to consider conditions when preparing solutions.

In summary, while the 3-(3-benzyl-3,9-diazabicyclo[3.3.1]nonan-9-yl)-N,N-dimethyl-propan-1-amine; dihydrate; trihydrochloride has favorable conditions for solubility in polar solvents, it is important to conduct empirical studies to determine exact solubility limits under various conditions. As the saying goes, “Dissolution is a dance between chemistry and nature,” where every factor can shift the rhythm dramatically.

Interesting facts

Interesting Facts about 3-(3-benzyl-3,9-diazabicyclo[3.3.1]nonan-9-yl)-N,N-dimethyl-propan-1-amine; dihydrate; trihydrochloride

This compound is an intriguing member of the class of bicyclic amines, featuring a complex structure that showcases the excitement of organic synthesis. Here are some key facts that highlight its significance:

  • Complex Structure: The compound incorporates a bicyclic framework, which is essential for its activity. The unique arrangement of atoms contributes to varied interactions in biochemical systems.
  • Pharmacological Potential: Compounds like this one often exhibit neuropharmacological properties, making them potential candidates in drug development. Their ability to interact with neurotransmitter systems is of particular interest.
  • Substituted Amines: The presence of dimethylamine and benzyl groups plays a crucial role in modulating the compound's properties, affecting both its solubility and biological activity.
  • Water of Hydration: The dihydrate form suggests interesting insights into the stability and reactivity of the compound under different conditions. Hydration can influence the physicochemical characteristics and biocompatibility.
  • Reactivity: Due to the presence of multiple functional groups, this compound exhibits a range of chemical reactivities, making it a versatile reactant in synthetic organic chemistry.

In summary, the sophistication embedded within 3-(3-benzyl-3,9-diazabicyclo[3.3.1]nonan-9-yl)-N,N-dimethyl-propan-1-amine; dihydrate; trihydrochloride not only enhances its utility in chemical research but also fuels exciting possibilities within medicinal chemistry. Its potential applications in pharmacological research underscore the dynamic nature of organic compounds.

Synonyms
23462-19-3
3-Benzyl-9-(2-(dimethylamino)propyl)-3,9-diazabicyclo(3.3.1)nonane hydrochloride hydrate
3,9-Diazabicyclo(3.3.1)nonane, 3-benzyl-9-(2-(dimethylamino)propyl)-, hydrochloride, hydrate (1:3:2)
RefChem:272781
DTXSID40946135
3-(3-Benzyl-3,9-diazabicyclo[3.3.1]nonan-9-yl)-N,N-dimethylpropan-1-amine--hydrogen chloride--water (1/3/2)