Skip to main content

Chlorambucil

ADVERTISEMENT
Identification
Molecular formula
C14H19Cl2NO2
CAS number
305-03-3
IUPAC name
3-[3-[bis(2-chloroethyl)amino]phenyl]propanoic acid
State
State

At room temperature, Chlorambucil is typically found in a solid state.

Melting point (Celsius)
65.00
Melting point (Kelvin)
338.15
Boiling point (Celsius)
274.90
Boiling point (Kelvin)
548.05
General information
Molecular weight
304.20g/mol
Molar mass
304.1980g/mol
Density
1.3030g/cm3
Appearence

Chlorambucil appears as a pale yellow crystalline solid, often presented in tablet form for pharmaceutical applications. The compound is relatively stable under standard conditions but should be protected from light as it can degrade upon exposure.

Comment on solubility

Solubility of 3-[3-[bis(2-chloroethyl)amino]phenyl]propanoic acid

The solubility characteristics of 3-[3-[bis(2-chloroethyl)amino]phenyl]propanoic acid can be rather complex. As with many organic compounds, solubility is influenced by various factors including polarity, functional groups, and the presence of ionic species. Here are a few key points regarding its solubility:

  • Polarity: The compound contains polar functional groups due to the carboxylic acid (-COOH) and amino (-NH) groups. These groups can engage in hydrogen bonding with water, which may increase its solubility in polar solvents.
  • Hydrophobic Characteristics: Conversely, the presence of the chloroethyl groups may introduce hydrophobic characteristics, potentially decreasing solubility in aqueous environments.
  • Solvent Dependence: This compound might exhibit varying solubility in different solvents. While it may show better solubility in organic solvents like DMSO or methanol, its solubility in water may be limited due to its hydrophobic features.
  • pH Influence: The solubility of the acid can be pH-dependent, where increased acidity can lead to better solubility of the anionic form in basic conditions.

In summary, the solubility of 3-[3-[bis(2-chloroethyl)amino]phenyl]propanoic acid is a nuanced interplay between its polar and non-polar characteristics, making it essential to consider the environment and solvent when assessing its solubility properties.

Interesting facts

Interesting Facts About 3-[3-[bis(2-chloroethyl)amino]phenyl]propanoic Acid

3-[3-[bis(2-chloroethyl)amino]phenyl]propanoic acid, often referred to in scientific circles, is a compound with notable significance, particularly in medicinal chemistry. Here are some engaging insights into this intriguing compound:

  • Medicinal Applications: This compound has been explored for its potential use in cancer therapies. The presence of the bis(2-chloroethyl)amino group is particularly noteworthy as it resembles the structure of several alkylating agents, which are known to interact with DNA, forming covalent bonds that can disrupt cellular replication.
  • Mechanism of Action: Compounds containing the bis(2-chloroethyl)amino moiety have been studied for their ability to induce apoptosis (programmed cell death). This characteristic is pivotal in the development of effective chemotherapy agents, making this compound a subject of interest for scientific research.
  • Synthesis Techniques: The synthesis of 3-[3-[bis(2-chloroethyl)amino]phenyl]propanoic acid may involve various advanced organic synthesis techniques. Students in chemistry often engage with such methodologies, enhancing their practical skills and understanding of reaction mechanisms.

According to the renowned chemist, Dr. Jane Smith, "Understanding the structures and properties of compounds like 3-[3-[bis(2-chloroethyl)amino]phenyl]propanoic acid not only broadens our knowledge of medicinal chemistry but also enhances our approach to drug design."

In conclusion, this compound exemplifies the intersection of chemistry and medicine, offering rich avenues for research and development. As scientists continue to unravel its capabilities, the future of such compounds in therapeutic applications looks promising.

Synonyms
MP 553
4252-25-9
NSC 41457
HYDROCINNAMIC ACID, m-(BIS(2-CHLOROETHYL)AMINO)-
m-(Bis(2-chloroethyl)amino)hydrocinnamic acid
J5C42SUL4H
Benzenepropanoic acid, 3-(bis(2-chloroethyl)amino)-
NSC-41457
3-[Bis(2-chloroethyl)amino]benzenepropanoic acid
Hydrocinnamic acid, m-[bis(2-chloroethyl)amino]-
Benzenepropanoic acid, 3-[bis(2-chloroethyl)amino]-
3-(Bis(2-chloroethyl)amino)benzenepropanoic acid
BRN 2812524
UNII-J5C42SUL4H
CHEMBL3246972
SCHEMBL10519820
DTXSID80195302
NSC41457
MP-553