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3-(3-chloro-4-ethoxy-phenyl)prop-2-enehydroxamic acid

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Identification
Molecular formula
C11H12ClNO3
CAS number
119123-82-3
IUPAC name
3-(3-chloro-4-ethoxy-phenyl)prop-2-enehydroxamic acid
State
State
At room temperature, the compound is a solid. Its crystalline nature allows it to be characterized by a particular texture and density, which is commonly acknowledged in laboratory settings.
Melting point (Celsius)
156.70
Melting point (Kelvin)
429.90
Boiling point (Celsius)
444.90
Boiling point (Kelvin)
718.00
General information
Molecular weight
225.67g/mol
Molar mass
225.6330g/mol
Density
1.2245g/cm3
Appearence

The compound typically manifests as a white to off-white solid at room temperature. It is often found in powdered form, and its appearance may be slightly granular depending on the level of purity and processing.

Comment on solubility

Solubility of 3-(3-chloro-4-ethoxy-phenyl)prop-2-enehydroxamic acid

The solubility of 3-(3-chloro-4-ethoxy-phenyl)prop-2-enehydroxamic acid can be influenced by various factors due to its unique chemical structure. Here are some key points to consider:

  • Polarity: The presence of hydroxamic acid functional groups generally enhances solubility in polar solvents such as water.
  • Hydrophobic Interactions: The ethoxy and chloro substituents contribute to hydrophobic characteristics, which may affect its solubility in non-polar solvents.
  • Temperature: Solubility may increase with temperature, leading to a greater dissolution rate in solvents.
  • pH Influence: As a hydroxamic acid, solubility can significantly change with pH variations; it typically dissolves better in alkaline conditions due to deprotonation.

This compound's solubility profile offers intriguing possibilities for applications, as it may vary based on the specific solvent and conditions utilized. Understanding these interactions is crucial for effective usage in laboratory or industrial settings.

Interesting facts

Interesting Facts about 3-(3-chloro-4-ethoxy-phenyl)prop-2-enehydroxamic acid

3-(3-chloro-4-ethoxy-phenyl)prop-2-enehydroxamic acid is a fascinating compound that merges the structural features of hydroxamic acids with specific substituents that impart unique properties. Here are some intriguing aspects of this compound:

  • Anticancer Potential: Hydroxamic acids are well-known for their ability to inhibit histone deacetylases. This property makes them promising candidates for cancer therapeutics, offering a pathway for new treatments in oncology.
  • Structure-Activity Relationship (SAR): The introduction of the 3-chloro and 4-ethoxy groups on the phenyl ring plays a critical role in defining the biological activity and selectivity of the compound, allowing scientists to explore modifications to enhance efficacy.
  • Chemical Versatility: The presence of the prop-2-ene functionality lends itself to various chemical reactions, including polymerization and conjugation strategies, making this compound versatile in synthetic organic chemistry.
  • Research Applications: Ongoing studies on this compound and its derivatives are focused on understanding their mechanisms of action, as well as potential synergies with existing cancer therapies.

In summary, 3-(3-chloro-4-ethoxy-phenyl)prop-2-enehydroxamic acid serves as an excellent example of how structural intricacies can lead to significant implications in medicinal chemistry, particularly within the realm of drug discovery and development. The exploration of such compounds not only enhances our understanding of biochemical pathways but also enriches the arsenal of tools available to tackle challenging diseases.