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loratadine

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Identification
Molecular formula
C22H23ClN2O
CAS number
79794-75-5
IUPAC name
3-[(3-chloro-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-yl)oxy]-N,N-dimethyl-propan-1-amine
State
State

At room temperature, loratadine is typically in a solid state as a crystalline powder.

Melting point (Celsius)
134.00
Melting point (Kelvin)
407.15
Boiling point (Celsius)
531.30
Boiling point (Kelvin)
804.50
General information
Molecular weight
382.89g/mol
Molar mass
382.8850g/mol
Density
0.9179g/cm3
Appearence

Loratadine is a white to off-white crystalline powder that is practically insoluble in water, but soluble in organic solvents such as ethanol, methanol, and chloroform.

Comment on solubility

Solubility Overview

The compound 3-[(3-chloro-7,8,9,10-tetrahydro-6H-cycloheptabquinolin-11-yl)oxy]-N,N-dimethyl-propan-1-amine exhibits unique solubility characteristics that are influenced by its complex molecular structure. Understanding its solubility is essential for applications in chemical synthesis and pharmaceutical formulation.

Solubility Characteristics

This compound is characterized by:

  • Polarity: The presence of the N,N-dimethylamino group typically increases solubility in polar solvents such as water, while the hydrophobic cyclohepta[b]quinoline structure may decrease solubility.
  • Solvent Interaction: This compound tends to dissolve better in organic solvents like ethanol and dimethyl sulfoxide (DMSO) due to its larger hydrophobic regions.
  • Temperature Dependency: Solubility often increases with temperature, making high-temperature applications conducive for dissolving this compound.

In general, when discussing solubility, it is important to remember:

  • pH Influence: Adjusting the pH may enhance its solubility due to protonation of amine groups.
  • Concentration: Higher concentrations might lead to saturation effects, limiting further dissolution.
  • Impurities: The presence of impurities can drastically affect solubility, either increasing or decreasing it.

In conclusion, while the solubility of 3-[(3-chloro-7,8,9,10-tetrahydro-6H-cycloheptabquinolin-11-yl)oxy]-N,N-dimethyl-propan-1-amine can generally be moderated by solvent choice and environmental conditions, challenges remain in predicting its exact solubility profile without empirical data.

Interesting facts

Interesting Facts about 3-[(3-chloro-7,8,9,10-tetrahydro-6H-cycloheptabquinolin-11-yl)oxy]-N,N-dimethyl-propan-1-amine

This compound is part of a complex class of chemicals known for their intriguing biological properties and therapeutic potential. Often utilized in pharmaceutical research, compounds like this one can exhibit significant activity against various diseases. Here are a few fascinating points to consider:

  • Chemical Structure: The presence of a cycloheptaquinoline structure indicates a fused ring system that may contribute to the compound's unique interactions within biological systems.
  • Biological Activity: Many similar compounds have shown promise as antipsychotic agents, making this compound a candidate for evaluating neuropharmacological effects.
  • Research Applications: This compound might be investigated for its ability to modulate neurotransmitter systems, particularly those related to Dopamine and Serotonin, which are crucial in mood regulation.
  • Synthetic Challenges: The synthesis of such complex molecules often involves intricate multi-step processes, allowing chemists to develop expertise in advanced organic synthesis techniques.

Additionally, the incorporation of a chloro group can enhance the compound's reactivity and alter its biological activity, leading to discussions about structure-activity relationships in medicinal chemistry.

In summary, the exploration of compounds like this one contributes significantly to the broad spectrum of medicinal chemistry, prompting ongoing research into their potential therapeutic effects and mechanisms of action. As highlighted by numerous studies, "the design of such intricately structured molecules is a testament to the ingenuity of chemists" who continue to explore the uncharted territories of pharmacology.