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Flecainide

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Identification
Molecular formula
C16H20F3N2O2
CAS number
54143-55-4
IUPAC name
3-[3-(dimethylamino)propyl]-5-(trifluoromethyl)-1,3-benzoxazol-2-one
State
State

At room temperature, Flecainide is in a solid state. It is typically marketed in tablet form for oral administration.

Melting point (Celsius)
141.00
Melting point (Kelvin)
414.15
Boiling point (Celsius)
281.00
Boiling point (Kelvin)
554.15
General information
Molecular weight
311.32g/mol
Molar mass
311.3160g/mol
Density
1.3930g/cm3
Appearence

Flecainide is typically observed as a white or almost white crystalline powder.

Comment on solubility

Solubility of 3-[3-(dimethylamino)propyl]-5-(trifluoromethyl)-1,3-benzoxazol-2-one

The solubility of 3-[3-(dimethylamino)propyl]-5-(trifluoromethyl)-1,3-benzoxazol-2-one is influenced by several key factors relating to its molecular structure. This compound features both polar and non-polar characteristics due to its functional groups. Here’s a closer look at its solubility properties:

  • Polarity: The presence of the dimethylamino group contributes to a polar character, which can enhance solubility in polar solvents such as water.
  • Fluorine Atoms: The trifluoromethyl group is highly electronegative, potentially influencing solubility by reducing overall molecular polarity, which may hinder solubility in water but improve it in organic solvents.
  • Solvent Interaction: The compound is likely to exhibit better solubility in organic solvents (e.g., ethanol, methanol) due to its hydrophobic regions.
  • Temperature Impact: Solubility can increase with temperature; thus, heating may promote greater dissolution in suitable solvents.

In summary, while **3-[3-(dimethylamino)propyl]-5-(trifluoromethyl)-1,3-benzoxazol-2-one** may demonstrate notable solubility in certain organic solvents, its overall behavior in aqueous environments could be more limited due to the balance of polar and non-polar characteristics. Understanding these factors is crucial for applications in various chemical and pharmaceutical contexts.

Interesting facts

Interesting Facts about 3-[3-(dimethylamino)propyl]-5-(trifluoromethyl)-1,3-benzoxazol-2-one

This compound is a member of the benzoxazole family, which consists of fused benzene and oxazole rings. Its unique structure lends itself to a variety of interesting properties and potential applications. Here are some noteworthy aspects:

  • Versatile Applications: Compounds like this one are often explored in the fields of pharmaceuticals and agrochemicals. Their ability to serve as intermediates in drug synthesis makes them valuable to medicinal chemists.
  • Fluorinated Features: The presence of the trifluoromethyl group significantly affects the compound's electronic properties. This group can enhance bioavailability and metabolic stability, potentially making drugs derived from this compound more effective.
  • Biological Activity: Variants of benzoxazole compounds are known for exhibiting various biological activities, including antibacterial, antifungal, and anticancer properties. Researchers are continually investigating pathways to harness these activities for therapeutic use.
  • Dimethylamino Influence: The dimethylamino group may contribute to the compound's lipophilicity, influencing its interaction with biological membranes and cellular targets. This aspect is crucial for its pharmacodynamics.

As a researcher or chemistry student, understanding the reactivity and behavior of such compounds is essential, particularly in synthesizing analogues that may improve efficacy or reduce side effects in drug candidates. This compound exemplifies the complexity and elegance of organic synthesis and the potential benefits of modifying specific functional groups.

In summary, 3-[3-(dimethylamino)propyl]-5-(trifluoromethyl)-1,3-benzoxazol-2-one is not only an intriguing scientific substance but also a gateway to exploring new medicinal strategies in modern chemistry.

Synonyms
3-[3-(dimethylamino)propyl]-5-(trifluoromethyl)-1,3-benzoxazol-2-one