Skip to main content

Deferasirox

ADVERTISEMENT
Identification
Molecular formula
C21H15N3O4
CAS number
201530-41-8
IUPAC name
3-[3-(hydroxyamino)-3-oxo-prop-1-enyl]benzenecarbohydroxamic acid
State
State
Deferasirox is typically a solid at room temperature. It tends to be stable under normal conditions of use and storage.

It can be manipulated as a solid powder for formulation into tablets or other dosage forms.

Melting point (Celsius)
265.50
Melting point (Kelvin)
538.70
Boiling point (Celsius)
595.60
Boiling point (Kelvin)
868.80
General information
Molecular weight
373.37g/mol
Molar mass
373.3650g/mol
Density
1.6860g/cm3
Appearence

Deferasirox appears as an off-white to slightly yellow solid. It is usually found as a crystalline powder, which may have slight variations in shade due to its synthesis and purification processes.

Comment on solubility

Solubility of 3-[3-(hydroxyamino)-3-oxo-prop-1-enyl]benzenecarbohydroxamic Acid

The solubility characteristics of the compound 3-[3-(hydroxyamino)-3-oxo-prop-1-enyl]benzenecarbohydroxamic acid, with the chemical formula C21H15N3O4, can be quite intriguing due to its structural components. This compound, featuring multiple functional groups, is likely to exhibit varying degrees of solubility depending on the solvent utilized.

Factors Influencing Solubility

  • Polarity: The presence of hydroxyl (–OH) and amine (–NH2) groups increases the polarity of the molecule, potentially enhancing solubility in polar solvents such as water.
  • Hydrogen Bonding: The ability of the compound to form hydrogen bonds with water molecules could further facilitate its solubility, unlike non-polar compounds which tend to be insoluble.
  • Temperature: Higher temperatures generally increase solubility for many compounds, which could be applicable here.
  • pH Conditions: As a hydroxamic acid, the solubility may also be affected by the pH of the solution, as ionization of the acidic functional group can lead to improved solubility.

In conclusion, while specific solubility data might not be readily available for this compound, it is expected that the unique combination of functional groups and their interactions with different solvents will provide insights into its solubility behavior. Exploring the solubility in various solvents can reveal much about its application potential and behavior in chemical reactions.

Interesting facts

Interesting Facts about 3-[3-(hydroxyamino)-3-oxo-prop-1-enyl]benzenecarbohydroxamic acid

This compound, known as 3-[3-(hydroxyamino)-3-oxo-prop-1-enyl]benzenecarbohydroxamic acid, belongs to a fascinating class of organic compounds called hydroxamic acids. Hydroxamic acids are recognized for their broad range of biological and pharmaceutical applications. Here are some intriguing aspects about this particular compound:

  • Biological Relevance: Hydroxamic acids, including this compound, have shown potential as inhibitors for various enzymes, particularly metalloproteinases and histone deacetylases, which play critical roles in cancer progression and other diseases. This positions them as important candidates for drug development.
  • Structure and Function: The unique structure of this compound includes both a hydroxamic acid functional group and a hydroxyamino group, which could affect its reactivity and interactions with biological targets. The presence of the prop-1-enyl group suggests possible reactivity that may be vital in synthetically modifying the compound for enhanced bioactivity.
  • Research Potential: Scientists are actively exploring hydroxamic acids in the field of medicinal chemistry. This compound may serve as a lead for developing new therapeutics, emphasizing the importance of its structure in creating derivatives with improved efficacy.
  • Mechanism of Action: The proposed mechanisms by which hydroxamic acids exert their effects often relate to their ability to chelate metal ions. This chelation can inhibit enzyme activity and lead to significant biological outcomes, which are crucial in designing targeted therapies.
  • Pharmaceutical Applications: Due to their ability to interfere with key biological processes, derivatives of hydroxamic acids are being studied for their potential in treating various conditions, including cancer and inflammatory diseases.

In conclusion, 3-[3-(hydroxyamino)-3-oxo-prop-1-enyl]benzenecarbohydroxamic acid exemplifies the intriguing properties of hydroxamic acids, showcasing their potential in therapeutic applications and paving the way for future research. As more studies unfold, our understanding of such compounds may lead to groundbreaking advancements in medicinal chemistry.

Synonyms
N-Hydroxy-3-(3-(hydroxyamino)-3-oxoprop-1-en-1-yl)benzamide
N-Hydroxy-3-[3-(hydroxyamino)-3-oxoprop-1-en-1-yl]benzamide
DTXSID00274380
Benzamide, N-hydroxy-3-[3-(hydroxyamino)-3-oxo-1-propenyl]-
AKOS028110667
DB-231488
H27302
N-hydroxy-3-[3-(hydroxyamino)-3-oxo-1-propen-1-yl]-benzamide
N-HYDROXY-3-[2-(HYDROXYCARBAMOYL)ETH-1-EN-1-YL]BENZAMIDE