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3-(3-piperidylmethyl)-1H-indole

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Identification
Molecular formula
C14H18N2
CAS number
10538-59-7
IUPAC name
3-(3-piperidylmethyl)-1H-indole
State
State

At room temperature, 3-(3-piperidylmethyl)-1H-indole is typically in a solid state, specifically as a crystalline solid.

Melting point (Celsius)
118.40
Melting point (Kelvin)
391.55
Boiling point (Celsius)
387.80
Boiling point (Kelvin)
660.95
General information
Molecular weight
224.31g/mol
Molar mass
224.3140g/mol
Density
1.1762g/cm3
Appearence

The compound 3-(3-piperidylmethyl)-1H-indole appears as a crystalline solid at room temperature. Its color can range from off-white to a pale yellow depending on the specific conditions and purity.

Comment on solubility

Solubility of 3-(3-piperidylmethyl)-1H-indole

The solubility of 3-(3-piperidylmethyl)-1H-indole is an important aspect that influences its application in various fields, including pharmaceuticals and chemical research. Here are some key points regarding its solubility:

  • Polar Character: The presence of the piperidine ring in the structure contributes to the compound's overall polarity, which may enhance its solubility in polar solvents such as water and methanol.
  • Hydrophobic Interactions: The indole portion of the molecule is relatively hydrophobic, which may reduce solubility in aqueous environments, indicating a balanced solubility profile influenced by its dual nature.
  • Solvent Dependence: Experimental solubility can vary significantly depending on the solvent used. Polar aprotic solvents like DMSO and DMF may solvate the compound more effectively than protic solvents.
  • Temperature Influence: As with many organic compounds, solubility typically increases with temperature, allowing for better solubility in solvents at elevated temperatures.

In summary, the solubility of 3-(3-piperidylmethyl)-1H-indole can be described as complex, influenced by both its molecular structure and the characteristics of the solvent. Understanding these factors is crucial for optimizing its use in various applications, as “solubility is a key player in determining bioavailability and chemical reactivity.”

Interesting facts

Exploring 3-(3-piperidylmethyl)-1H-indole

3-(3-piperidylmethyl)-1H-indole is an intriguing compound that belongs to a class of chemicals known for their biological significance. Here are some fascinating insights into this compound:

  • Structural Diversity: The compound features a unique indole structure, which is a bicyclic compound consisting of a benzene and pyrrole ring. This structural composition contributes to its reactivity and potential interactions.
  • Pharmacological Potential: Indole derivatives are widely studied for their pharmacological properties. Compounds like 3-(3-piperidylmethyl)-1H-indole may exhibit pharmacological activities that can be useful in developing new medications.
  • Role in Neuroscience: The presence of the piperidine moiety suggests possible interactions with neurotransmitter systems, making this compound a candidate for research in neuroscience and psychopharmacology.
  • Synthetic Challenges: The synthesis of 3-(3-piperidylmethyl)-1H-indole can present challenges due to the need for precision in maintaining its structural integrity during chemical reactions. Understanding these challenges is crucial for chemists aiming to produce this compound efficiently.

In summary, 3-(3-piperidylmethyl)-1H-indole stands out as a compound rife with potential, particularly in medicinal chemistry. The harmony between its structure and possible biological activity invokes a deeper exploration into its applications. As researchers continue to unveil its properties, it might just play a significant role in the future of therapeutics.

Synonyms
3-Skatylpiperidine
BRN 1573445
INDOLE, 3-(3-PIPERIDYLMETHYL)-
5275-08-1
5-23-07-00421 (beilstein handbook reference)
3-[(Piperidin-3-yl)methyl]-1H-indole
DTXSID60967201
AKOS016353918
EN300-1851367