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Trimethoprim

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Identification
Molecular formula
C14H18N4O3
CAS number
738-70-5
IUPAC name
3-(3,3-diphenylpropylamino)propyl 3,4,5-trimethoxybenzoate
State
State

Trimethoprim is typically found in a solid state at room temperature.

Melting point (Celsius)
199.00
Melting point (Kelvin)
472.15
Boiling point (Celsius)
523.70
Boiling point (Kelvin)
796.90
General information
Molecular weight
290.34g/mol
Molar mass
290.3430g/mol
Density
1.2100g/cm3
Appearence

Trimethoprim is a white to light yellow crystalline powder. It is odorless and has a bitter taste. The powder is slightly soluble in water and moderately soluble in ethanol.

Comment on solubility

Solubility of 3-(3,3-diphenylpropylamino)propyl 3,4,5-trimethoxybenzoate

The solubility of 3-(3,3-diphenylpropylamino)propyl 3,4,5-trimethoxybenzoate is a topic of considerable importance, particularly given its complex structure. Being a benzoate ester, several factors influence its solubility in different solvents:

  • Polarity: The presence of the trimethoxy groups introduces a degree of hydrophilicity, potentially enhancing solubility in polar solvents like methanol and ethanol.
  • Hydrophobic Interactions: The significant phenyl groups contribute to hydrophobicity, which may limit solubility in water, suggesting a greater solubility in organic solvents such as chloroform or dichloromethane.
  • Temperature Dependency: Solubility can vary significantly with temperature, often increasing at higher temperatures.
  • pH Influence: The solubility profile may also change with pH, particularly if the compound can ionize under specific conditions.

In a practical sense, it is essential for researchers and formulators to conduct empirical solubility tests to determine the exact solubility of this compound in various solvents. As a general guideline, "like dissolves like" can be a handy rule to remember when predicting the solubility of organic compounds.

Interesting facts

Interesting Facts about 3-(3,3-Diphenylpropylamino)propyl 3,4,5-trimethoxybenzoate

This fascinating compound, often abbreviated in the scientific community, has a variety of applications and intriguing properties that make it a subject of interest among chemists and pharmacologists alike. Here are some noteworthy points:

  • Structural Complexity: The presence of multiple aromatic rings and methoxy groups illustrates the compound's structural diversity. This complexity can contribute to its unique reactivity and biological activity.
  • Potential Therapeutic Uses: Compounds with similar structures have shown promising properties in medicinal chemistry, often functioning as modulators or inhibitors in various biological pathways.
  • Role of Methoxy Groups: The methoxy groups within the benzoate moiety can enhance the lipophilicity of the compound, which may influence its ability to cross biological membranes, potentially affecting its pharmacokinetics.
  • Research Applications: This compound can be used in drug design and discovery, as it provides a scaffold for further chemical modifications that may develop more effective therapeutic agents.
  • Historical Context: Understanding compounds like this can help trace the evolution of drug discovery and medicinal chemistry, as researchers explore how small changes in chemical structure can lead to vastly different biological outcomes.

As with many compounds in organic chemistry, 3-(3,3-diphenylpropylamino)propyl 3,4,5-trimethoxybenzoate also invites questions about its synthesis, stability, and reactivity. The meticulous process of creating such compounds is fundamental in creating new medications and exploring unknown biological interactions.

In conclusion, the study of this compound not only broadens our understanding of chemical properties but also enriches the field of medicinal chemistry, paving the way for innovative therapies and advancements in drug development.

Synonyms
Mepramidil
23891-60-3
Mepramidilum
PF-26
5C8KR48J61
DTXSID40178590
3,4,5-Trimethoxybenzoic acid, 3-((3,3-diphenylpropyl)amino)propyl ester
RefChem:156520
DTXCID00101081
Mepramidil [INN]
3-(3,3-diphenylpropylamino)propyl 3,4,5-trimethoxybenzoate
3-((3,3-diphenylpropyl)amino)propyl 3,4,5-trimethoxybenzoate
Mepramidilum [INN-Latin]
UNII-5C8KR48J61
3-(3,3-Diphenylpropylamino)propyl-3',4',5'-trimethoxybenzoate hydrochloride
orb1696154
SCHEMBL2110178
CHEMBL2105186
3-(3,3-Diphenylpropylamino)propyl 3,4,5-trimethoxybenzoat
AKOS040752998
Q27261825