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3-(3,4-dimethoxyphenyl)prop-2-enehydroxamic acid

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Identification
Molecular formula
C11H13NO4
CAS number
66345-05-7
IUPAC name
3-(3,4-dimethoxyphenyl)prop-2-enehydroxamic acid
State
State

At room temperature, 3-(3,4-dimethoxyphenyl)prop-2-enehydroxamic acid exists as a solid.

Melting point (Celsius)
138.00
Melting point (Kelvin)
411.15
Boiling point (Celsius)
58.00
Boiling point (Kelvin)
331.15
General information
Molecular weight
225.24g/mol
Molar mass
225.2440g/mol
Density
1.2300g/cm3
Appearence

The compound 3-(3,4-dimethoxyphenyl)prop-2-enehydroxamic acid typically appears as a crystalline solid. The color may vary from white to off-white depending on purity and specific preparation methods.

Comment on solubility

Solubility of 3-(3,4-dimethoxyphenyl)prop-2-enehydroxamic acid

The solubility of 3-(3,4-dimethoxyphenyl)prop-2-enehydroxamic acid can be described with several key points:

  • Polarity: The presence of hydroxamic acid functional groups tends to enhance solubility in polar solvents such as water due to hydrogen bonding capabilities.
  • Aromatic Influence: The inclusion of the 3,4-dimethoxyphenyl group can introduce lipophilicity, making the compound more soluble in organic solvents.
  • Hydrogen Bonding: The hydroxyl group facilitates interaction with water molecules, which can significantly increase solubility.
  • Temperature Dependency: Generally, an increase in temperature may improve solubility for many organic compounds, and this might also apply to this compound.

Overall, it is likely that 3-(3,4-dimethoxyphenyl)prop-2-enehydroxamic acid possesses moderate water solubility, while showing higher solubility in organic solvents. As with all chemical compounds, the specific conditions (like pH and temperature) will greatly influence its solubility profile.

Interesting facts

Interesting Facts about 3-(3,4-Dimethoxyphenyl)prop-2-enehydroxamic Acid

3-(3,4-Dimethoxyphenyl)prop-2-enehydroxamic acid is a fascinating compound that attracts attention in both organic chemistry and medicinal chemistry due to its unique structure and potential applications. Here are some key points that highlight its significance:

  • Structure Highlights: This compound features a distinctive hydroxamic acid functional group, which is known for its ability to form chelates with metal ions. This property often plays a crucial role in various biochemical processes.
  • Biological Activity: Compounds like 3-(3,4-Dimethoxyphenyl)prop-2-enehydroxamic acid could exhibit inhibitory activity against certain enzymes, making them subjects of interest for drug design and development, especially in treating cancer and other diseases.
  • Synthetic Routes: The synthesis of this compound can provide excellent learning opportunities for students, as it typically involves multiple steps, including selective functionalization and purification techniques that are central to organic synthesis.
  • Research Insights: Scientific literature has begun to explore the potential of hydroxamic acids in the treatment of various conditions, including their role as Histone Deacetylase (HDAC) inhibitors, which are being studied in relation to cancer therapy.
  • Applications Beyond Medicine: Apart from medicinal chemistry, such compounds may also find applications in agricultural chemistry as potential herbicides or pesticides due to their ability to interact with biological systems.

Exploring compounds like 3-(3,4-Dimethoxyphenyl)prop-2-enehydroxamic acid not only enriches our understanding of organic chemistry but also opens doors to innovations in therapeutic interventions and agricultural practices. As research continues, this compound may indeed unveil new dimensions in various fields of science.

Synonyms
3,4-Dimethoxycinnamohydroxamic acid
SCHEMBL10562864
FAKIVHFFVVPOKL-UHFFFAOYSA-N
3-(3,4-Dimethoxyphenyl)-2-propenehydroximic acid