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Orantinib

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Identification
Molecular formula
C16H8Br2I NO2
CAS number
264624-41-1
IUPAC name
3-[(3,5-dibromo-4-hydroxy-phenyl)methylene]-5-iodo-indolin-2-one
State
State

At room temperature, the compound is a solid.

Melting point (Celsius)
282.00
Melting point (Kelvin)
555.00
Boiling point (Celsius)
655.10
Boiling point (Kelvin)
928.30
General information
Molecular weight
570.94g/mol
Molar mass
570.9440g/mol
Density
1.9000g/cm3
Appearence

The compound typically appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of 3-[(3,5-dibromo-4-hydroxy-phenyl)methylene]-5-iodo-indolin-2-one

The solubility characteristics of the compound 3-[(3,5-dibromo-4-hydroxy-phenyl)methylene]-5-iodo-indolin-2-one (C16H8Br2I NO2) are influenced by its complex molecular structure and the presence of halogen atoms. Here are some key points regarding its solubility:

  • Polarity: The compound has a variety of functional groups, which contribute to its overall polarity. This may affect its solubility in polar solvents.
  • Solubility in Organic Solvents: Given its structure, it is likely to be more soluble in organic solvents such as:
    • Dimethyl sulfoxide (DMSO)
    • Acetone
    • Acetonitrile
  • Water Solubility: Due to the presence of bromine and iodine atoms, which increase molecular weight and influence hydrogen bonding, the solubility in water may be limited. Thus, it is expected to be insoluble or sparingly soluble in aqueous solutions.

In summary, the solubility of 3-[(3,5-dibromo-4-hydroxy-phenyl)methylene]-5-iodo-indolin-2-one is likely to be high in non-polar and moderately polar organic solvents but poor in water. To further investigate specific solubility behaviors, experimental data is recommended.

Interesting facts

Interesting Facts About 3-[(3,5-dibromo-4-hydroxy-phenyl)methylene]-5-iodo-indolin-2-one

This intriguing compound is a unique derivative of indolinone, which has garnered attention in various fields of research due to its potential applications. Here are some interesting aspects of this compound:

  • Pharmacological Potential: Compounds containing indolinone structures have been studied for their antitumor and antivirus properties, indicating a potential role in drug development.
  • Halogen Influence: The presence of multiple halogens, specifically bromine and iodine atoms, may enhance the compound's biological activity and stability, making it an interesting candidate for further studies.
  • Structural Complexity: The unique arrangement of functional groups, including a hydroxy and methylene moiety, provides avenues for structure-activity relationship (SAR) studies, which are vital in medicinal chemistry.
  • Diversity of Reaction Pathways: This compound can act as a building block in organic synthesis, enabling the creation of new derivatives through various chemical transformations, such as substitutions or couplings.
  • Research Applications: With its unique chemical properties, this compound is a valuable tool for studying biological mechanisms or developing new therapeutic agents in modern medicinal chemistry.

In the words of a seasoned chemist, “The beauty of synthetic chemistry lies in exploiting the versatility of compounds such as these; they can lead to new discoveries and innovations.”
Its multifaceted nature makes 3-[(3,5-dibromo-4-hydroxy-phenyl)methylene]-5-iodo-indolin-2-one not just a compound of interest, but a gateway to unlocking potential scientific advancements.

Synonyms
GW305074X
3-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-5-iodo-1H-indol-2-one
C15H8Br2INO2
KBioGR_000615
KBioSS_000615
CHEMBL1880739
KBio2_000615
KBio2_003183
KBio2_005751
KBio3_001089
KBio3_001090
LMXYVLFTZRPNRV-UHFFFAOYSA-N
Bio2_000468
Bio2_000948
HMS2043P21
HMS3265E15
HMS3265E16
HMS3265F15
HMS3265F16
HMS3267D12
HMS3651B04
BDBM50289149
LP00510
SB19424
NCGC00015478-08
NCGC00241988-01
DB-185866
SW212797-2
Q27163219