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Flumizole

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Identification
Molecular formula
C16H14F3N3O3
CAS number
3289-34-9
IUPAC name
3-[3,5-dimethyl-4-[3-(3-methylisoxazol-5-yl)propoxy]phenyl]-5-(trifluoromethyl)-1,2,4-oxadiazole
State
State

At room temperature, Flumizole is commonly found as a solid. Its stable solid form makes it suitable for various applications in the chemical industry.

Melting point (Celsius)
179.00
Melting point (Kelvin)
452.15
Boiling point (Celsius)
530.00
Boiling point (Kelvin)
803.15
General information
Molecular weight
331.29g/mol
Molar mass
331.2910g/mol
Density
1.3600g/cm3
Appearence

Flumizole typically presents as a white crystalline solid. The compound is known for its crystalline nature and is usually handled in powdered form.

Comment on solubility

Solubility of 3-[3,5-dimethyl-4-[3-(3-methylisoxazol-5-yl)propoxy]phenyl]-5-(trifluoromethyl)-1,2,4-oxadiazole

The solubility of the compound 3-[3,5-dimethyl-4-[3-(3-methylisoxazol-5-yl)propoxy]phenyl]-5-(trifluoromethyl)-1,2,4-oxadiazole (C16H14F3N3O3) can be influenced by several key factors:

  • Molecular Structure: The presence of functional groups, in particular, the trifluoromethyl and oxadiazole moieties, can significantly affect how this compound interacts with solvents.
  • Polarity: Due to its varied structural components, this compound may exhibit moderate polarity, leading to differential solubility in polar and non-polar solvents.
  • Temperature: As with many chemical compounds, solubility can increase with temperature, allowing greater dissolution in solvent.
  • Solvent Compatibility: It is essential to consider solvent types—this compound may be more soluble in organic solvents such as dimethyl sulfoxide (DMSO) or other polar aprotic solvents compared to water.

In summary, the unique characteristics of 3-[3,5-dimethyl-4-[3-(3-methylisoxazol-5-yl)propoxy]phenyl]-5-(trifluoromethyl)-1,2,4-oxadiazole suggest that its solubility may be variable, highlighting the importance of conducting specific solubility tests in order to determine the best solvent for practical applications. As a rule of thumb, experimentation and consultation of solubility data are critical in predicting the behavior of this compound in various environments.

Interesting facts

Interesting Facts About 3-[3,5-Dimethyl-4-[3-(3-methylisoxazol-5-yl)propoxy]phenyl]-5-(trifluoromethyl)-1,2,4-oxadiazole

This unique compound, commonly known as a member of the oxadiazole family, has gained attention in the field of medicinal chemistry due to its potential applications. Here are some noteworthy aspects:

  • Pharmacological Interest: Compounds containing oxadiazole rings exhibit a variety of biological activities. This particular compound has shown promise in preliminary studies for anti-inflammatory and anticancer properties.
  • Structure-Activity Relationship: The presence of both trifluoromethyl and dimethyl groups on the aromatic ring enhances lipophilicity and biological efficacy. This is a prime illustration of how subtle modifications in molecular structure can lead to significant changes in activity.
  • Isomer Variations: Different isomers of oxadiazoles can have vastly different properties, making the study of these compounds particularly fascinating. This compound’s specific arrangement leads to its unique reactivity and interactions at the molecular level.
  • Diverse Applications: Beyond medicinal uses, oxadiazole derivatives are also researched for their potential as fluorescent materials and in photovoltaic devices due to their efficient electron transport properties.

As with many compounds, further exploration is necessary to fully understand the mechanisms at play when it interacts with biological systems. It’s exciting to consider how this intricate balancing of chemistry and biology could lead to breakthrough therapies in the future.

In the words of chemist Linus Pauling, "The best way to have a good idea is to have a lot of ideas." This compound embodies that spirit, representing both the complexity of chemical research and the potential for unexpected discoveries!

Synonyms
Pleconaril
153168-05-9
Picovir
Win-63843
VP-63843
Win 63843
Pleconaril [USAN:INN]
Pleconaril-d8
Pleconarilo
VP 63843
3-(3,5-dimethyl-4-(3-(3-methylisoxazol-5-yl)propoxy)phenyl)-5-(trifluoromethyl)-1,2,4-oxadiazole
DTXSID8057649
PLECONARIL [MI]
WIN63843
PLECONARIL [INN]
PLECONARIL [USAN]
3-[3,5-dimethyl-4-[3-(3-methyl-1,2-oxazol-5-yl)propoxy]phenyl]-5-(trifluoromethyl)-1,2,4-oxadiazole
3-{3,5-dimethyl-4-[3-(3-methyl-isoxazol-5-yl)-propoxy]-phenyl}-5-trifluoromethyl-[1,2,4]oxadiazole
9H4570Q89D
PLECONARIL [MART.]
PLECONARIL [WHO-DD]
CHEMBL29609
3-[3,5-Dimethyl-4-[3-(3-methyl-5-isoxazolyl)propoxy]phenyl]-5-(trifluoromethyl)-1,2,4-oxadiazole
3-[3,5-dimethyl-4-[3-(3-methylisoxazol-5-yl)propoxy]phenyl]-5-(trifluoromethyl)-1,2,4-oxadiazole
DTXCID9031438
3-(4-(3-(3-Methyl-5-isoxazolyl)propoxy)-3,5-xylyl)-5-trifluoromethyl)-1,2,4-oxadizole
3-(3,5-Dimethyl-4-(3-(3-methyl-5-isoxazolyl)propoxy)phenyl)-5-(trifluoromethyl)-1,2,4-oxadiazole
VP63843
PLECONARIL (MART.)
1,2,4-Oxadiazole, 3-(3,5-dimethyl-4-(3-(3-methyl-5-isoxazolyl)propoxy)phenyl)-5-(trifluoromethyl)-
3-(3,5-dimethyl-4((3-(3-methyl-5-isoxazolyl)propyl)phenyl)-5-trifluoromethyl)-1,2,4-oxadiazole
3-(3,5-dimethyl-4-(3-(3-methyl-1,2-oxazol-5-yl)propoxy)phenyl)-5-(trifluoromethyl)-1,2,4-oxadiazole
W11
pleconarilum
Pleconarilis?
SR-263843
UNII-9H4570Q89D
1,2,4-Oxadiazole, 3-[3,5-dimethyl-4-[3-(3-methyl-5-isoxazolyl)propoxy]phenyl]-5-(trifluoromethyl)-
3-[3,5-Dimethyl-4-[3-(3-methyl-5-isoxazolyl)propoxy]phenyl]-5-(trifluoromethyl)-1,2,4-oxadiazole; Picovir; Pleconaril; VP 63843; Win 63843
3-{3,5-dimethyl-4-[3-(3-methylisoxazol-5-yl)propoxy]phenyl}-5-(trifluoromethyl)-1,2,4-oxadiazole
MFCD00923611
Pleconaril (Standard)
SR-63843
Pleconaril (USAN/INN)
SCHEMBL49383
Pleconaril - Bio-X trade mark
Pleconaril, >=98% (HPLC)
J05AX06
KQOXLKOJHVFTRN-UHFFFAOYSA-N
GLXC-10515
BCP20819
EX-A1448
Tox21_113756
BDBM50111469
HY-19952R
AKOS016005860
Pleconaril;VP 63843;Win 63843
CS-5475
DB05105
FP27098
NCGC00253627-01
5-[3-[2,6-dimethyl-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenoxy]propyl]-3-methylisoxazole
AC-36849
AS-77268
BP300112
HY-19952
Pleconaril 100 microg/mL in Acetonitrile
DB-012510
CAS-153168-05-9
NS00068598
D05528
F20826
Q770293
SR-01000945059
SR-01000945059-1
BRD-K27625831-001-01-1
BRD-K27625831-001-02-9
1,3-Dimethyl-2-[3-(3-methylisoxazol-5-yl)propoxy]-5-[5-(trifluoromethyl)(1,2,4-oxadiazol-3-yl)]benzene
3-{3,5-Dimethyl-4-[3-(3-methyl-isoxazol-5-yl)-propoxy]-phenyl}-5-trifluoromethyl-[1,2,4]oxadiazole(Pleconaril)
683-423-9
Pleconaril3-{3,5-Dimethyl-4-[3-(3-methyl-isoxazol-5-yl)-propoxy]-phenyl}-5-trifluoromethyl-[1,2,4]oxadiazole