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Digoxin

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Identification
Molecular formula
C41H64O14
CAS number
20830-75-5
IUPAC name
3-[(3R,5R,10S,13R,14S,17R)-3,14-dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2H-furan-5-one
State
State

At room temperature, digoxin is typically in a solid state as a crystalline powder. It remains stable under normal conditions of storage and handling. The compound requires specific conditions to maintain its pharmacological properties and is generally stored in well-sealed containers.

Melting point (Celsius)
230.00
Melting point (Kelvin)
503.00
Boiling point (Celsius)
174.00
Boiling point (Kelvin)
447.00
General information
Molecular weight
780.94g/mol
Molar mass
780.9440g/mol
Density
1.2800g/cm3
Appearence

Digoxin appears as a white to off-white crystalline powder. It is practically insoluble in water, slightly soluble in ethanol (approximately 1.5%), and more soluble in chloroform and methanol. Due to its chemical nature, the powder is typically handled in a controlled environment to prevent degradation.

Comment on solubility

Solubility of 3-[(3R,5R,10S,13R,14S,17R)-3,14-dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2H-furan-5-one

The solubility of the compound 3-[(3R,5R,10S,13R,14S,17R)-3,14-dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2H-furan-5-one can be quite intriguing, given its complex structure. Understanding solubility is key in various applications, especially in pharmaceuticals and materials science. Here are some factors that influence its solubility:

  • Molecular Structure: The presence of both hydrophobic (e.g., the tetradecahydrocylcopenta[a]phenanthren moiety) and hydrophilic groups (e.g., the hydroxyl groups) can create a balance that affects how well the compound dissolves in various solvents.
  • Solvent Interactions: The solubility is typically higher in polar solvents like water or alcohols compared to non-polar solvents, owing to the ability of solvents to stabilize different interactions.
  • pH Influence: The compound may exhibit variable solubility in different pH environments due to potential ionization of functional groups, such as hydroxyls.

In practical terms, one might find that:
- **High solubility** could make the compound useful in drug formulations.
- **Low solubility** might necessitate methods such as solubilizing agents or the use of specific formulations to enhance bioavailability or effectiveness.

As stated, "Solubility is not just a property, it’s a crucial determinant of function." Understanding the solubility of this compound can unlock numerous possibilities in research and application, making it a significant area of focus for chemists and material scientists alike.

Interesting facts

Interesting Facts about 3-[(3R,5R,10S,13R,14S,17R)-3,14-dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2H-furan-5-one

This compound is a fascinating example of a complex organic molecule featuring a combination of both steroid-like and furan structures, contributing to its interesting biological, pharmacological, and chemical properties.

Key Characteristics:

  • Steroid framework: The tetradecahydrocyclopenta[a]phenanthrene core provides a steroid-like structure, which can interact with various biological receptors.
  • Hydroxyl Groups: The presence of multiple hydroxyl groups is significant as it enhances the compound’s reactivity and solubility, potentially influencing its biological activity.
  • Furan ring: The furan moiety contributes not only to the compound's chemical reactivity but also extends its functional range, making it a subject of interest in organic synthesis.

This compound is often studied for its potential applications in medicinal chemistry due to the effects of similar compounds in human biochemistry. Researchers have cited various biological activities linked to the steroid core, such as anti-inflammatory and anticancer properties, highlighting its importance in developing therapeutic agents.

"Nature often presents us with complex structures that can lead to revolutionary discoveries." This quote encapsulates the role of such compounds in expanding our understanding of chemical interactions and facilitating new drug designs.

In summary, 3-[(3R,5R,10S,13R,14S,17R)-3,14-dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2H-furan-5-one is a captivating compound that illustrates the intricate dance of molecular structure and function in chemistry.

Synonyms
3-Epidigitoxigenin
G89182