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Digoxin

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Identification
Molecular formula
C41H64O14
CAS number
20830-75-5
IUPAC name
3-[(3S,5R,10S,13R,14S,17R)-14-hydroxy-10,13-dimethyl-3-[(2S,5S)-3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl]oxy-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2H-furan-5-one
State
State

At room temperature, digoxin is typically in a solid crystalline state. It is stable under normal conditions but requires appropriate storage to prevent decomposition.

Melting point (Celsius)
249.30
Melting point (Kelvin)
522.45
Boiling point (Celsius)
740.00
Boiling point (Kelvin)
1 013.15
General information
Molecular weight
780.95g/mol
Molar mass
780.9480g/mol
Density
1.1000g/cm3
Appearence

Digoxin appears as a white or almost white, odorless, crystalline powder. It is typically elongated, with a bitter taste.

Comment on solubility

Solubility of 3-[(3S,5R,10S,13R,14S,17R)-14-hydroxy-10,13-dimethyl-3-[(2S,5S)-3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl]oxy-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2H-furan-5-one

The solubility of complex organic compounds like 3-[(3S,5R,10S,13R,14S,17R)-14-hydroxy-10,13-dimethyl-3-[(2S,5S)-3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl]oxy-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2H-furan-5-one can be quite intricate. Factors influencing the solubility of this compound include:

  • Molecular Structure: The presence of multiple hydroxyl (-OH) groups generally enhances solubility in polar solvents, while larger hydrophobic portions of the molecule can lead to low solubility in water.
  • Polarity: Due to its polar and nonpolar regions, it may exhibit variable solubility in different solvents, often soluble in organic solvents but poorly in polar solvents.
  • Hydrogen Bonding: The hydroxyl groups can engage in hydrogen bonding with solvents, which can improve solubility in polar media.
  • Temperature: Increasing the temperature often increases solubility; however, this can be compound-specific based on interactions among the molecules.

As a general observation, complex compounds like this one often require detailed solubility studies to fully understand their behavior in various solvents. It's not uncommon to conclude that 'the solubility of this compound is likely low in water, but it may dissolve in organic solvents such as ether or alcohol.' Experimental data should ideally support these insights to confirm solubility characteristics for practical applications.

Interesting facts

Exploring the Wonders of 3-[(3S,5R,10S,13R,14S,17R)-14-hydroxy-10,13-dimethyl-3-[(2S,5S)-3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl]oxy-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2H-furan-5-one

This compound, often referred to in scientific literature for its complex structure, is part of a fascinating family of natural products known for their biological activity. The intricate arrangement of its atoms allows for a myriad of interactions at the molecular level.

Key Noteworthy Aspects:

  • Natural Origins: Compounds such as this may be derived from a variety of natural sources, which means they can be closely related to hormones or steroids found in biological systems.
  • Biological Significance: Some studies suggest that components with similar structures can exhibit significant pharmacological properties, potentially influencing various biochemical pathways.
  • Stereochemical Complexity: The multiple stereocenters present in this compound highlight the importance of chirality in chemistry, affecting the way the compound interacts with biological targets.
  • Potential Therapeutic Uses: Research into compounds like this one may lead to the development of new medicinal therapies, particularly in the fields of oncology or anti-inflammation.

"Molecular structure dictates function," a common phrase among chemists, rings especially true for compounds like this, where slight alterations could drastically change biological activity.

Overall, the exploration of this unique compound serves not only as a testament to the complexity of organic molecules but also as a reminder of the vast potential within nature's chemistry waiting to be unlocked for various applications in medicine and beyond.