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Frovatriptan

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Identification
Molecular formula
C14H17ClN2O
CAS number
158747-02-5
IUPAC name
3-[4-[2-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-indol-3-yl]acetyl]oxyethyl]piperazin-1-yl]propyl 4-benzamido-5-(dipropylamino)-5-oxo-pentanoate
State
State

At room temperature, Frovatriptan is typically in a solid state.

Melting point (Celsius)
158.00
Melting point (Kelvin)
431.15
Boiling point (Celsius)
522.10
Boiling point (Kelvin)
795.25
General information
Molecular weight
379.47g/mol
Molar mass
379.4720g/mol
Density
1.2955g/cm3
Appearence

Frovatriptan appears as a white to off-white powder. It is typically provided in a solid state as tablets or powder for pharmaceutical uses.

Comment on solubility

Solubility Overview

The compound 3-[4-[2-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-indol-3-yl]acetyl]oxyethyl]piperazin-1-yl]propyl 4-benzamido-5-(dipropylamino)-5-oxo-pentanoate with the chemical formula C14H17ClN2O exhibits interesting solubility characteristics.

Solubility Characteristics

This compound is likely to present varied solubility depending on the solvent used, influenced by its molecular structure:

  • Polar Solvents: Given the presence of polar functional groups, such as the piperazine and chloro substituents, the compound may show moderate solubility in polar solvents like water and alcohol.
  • Non-Polar Solvents: The hydrophobic regions, attributed to the benzoyl and dipropylamino groups, may enhance solubility in non-polar solvents such as chloroform or hexane.
  • pH Dependence: Solubility may also vary with pH levels due to the potential ionization of functional groups, impacting the compound's overall polarity.

As a result, one could anticipate that “the solubility of this compound is contingent upon its environment, demonstrating the classic principle: 'like dissolves like.'” Experimentation would provide precise insights into its solubility profile. Understanding this aspect is crucial for applications in pharmaceuticals and drug formulation.

Interesting facts

Interesting Facts about 3-[4-[2-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-indol-3-yl]acetyl]oxyethyl]piperazin-1-yl]propyl 4-benzamido-5-(dipropylamino)-5-oxo-pentanoate

This compound is a complex organic molecule that showcases a remarkable array of functional groups and structural motifs, making it a significant subject of study in medicinal chemistry. Here are some intriguing aspects of this compound:

  • Pharmaceutical Potential: Due to its intricate structure, which combines elements of indole and piperazine, this compound may exhibit potential pharmaceutical properties, including activity as a receptor modulator.
  • Chlorine Atom: The presence of a chlorine atom in the aromatic ring not only influences the compound's electronic properties but may also enhance its lipophilicity, potentially improving its bioavailability.
  • Indole Moiety: Indoles are a well-known class of compounds in drug discovery, providing a backbone for numerous therapeutic agents due to their role in biological processes.
  • Functional Diversity: With multiple functional groups, such as esters and amides, this compound demonstrates significant chemical diversity, which can play a crucial role in target specificity and interaction mechanisms.
  • Structure-Activity Relationship (SAR): Given its complex arrangement, understanding how each parts influence the biological activity could yield valuable insights, making it a prime candidate for SAR studies.

As students and researchers delve into the properties of this compound, they can appreciate not only its sophisticated architecture but also the potential implications for developing new therapies. As the renowned chemist Linus Pauling once said, "The best way to have a good idea is to have lots of ideas." This compound stands as an example of how intricate design can lead to inspiring innovations in pharmaceuticals.

Synonyms
PROGLUMETACIN
57132-53-3
Proglumetacina
Proglumetacine
Proglumetacinum
Proglumetacin [INN:BAN]
Proglumetacine [INN-French]
Proglumetacinum [INN-Latin]
Proglumetacina [INN-Spanish]
UNII-FV919079LU
Proglumetacin (INN)
3-[4-[2-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetyl]oxyethyl]piperazin-1-yl]propyl 4-benzamido-5-(dipropylamino)-5-oxopentanoate
DTXSID0048842
CHEBI:76263
FV919079LU
PROGLUMETACIN [MI]
PROGLUMETACIN [INN]
PROGLUMETACIN [WHO-DD]
DTXCID3028768
NCGC00183024-01
Bruxel (TN)
Proglumetacine (INN-French)
Proglumetacinum (INN-Latin)
3-(4-(2-Hydroxyethyl)-1-piperazinyl)propyl DL-4-benzamido-N,N-dipropylglutaramate 1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetate (ester)
Proglumetacina (INN-Spanish)
Proglumetacina [Spanish]
5-(DIPROPYLAMINO)-1,5-DIOXOPENTYL)OXY)PROPYL)-1-PIPERAZINYL)ETHYL ESTER, (+/-)-
1H-INDOLE-3-ACETIC ACID, 1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-, 2-(4-(3-((4-(BENZOYLAMINO)-
1H-INDOLE-3-ACETIC ACID, 1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-, 2-(4-(3-((4-(BENZOYLAMINO)-5-(DIPROPYLAMINO)-1,5-DIOXOPENTYL)OXY)PROPYL)-1-PIPERAZINYL)ETHYL ESTER
3-(4-(2-(2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetoxy)ethyl)piperazin-1-yl)propyl 4-benzamido-5-(dipropylamino)-5-oxopentanoate
3-[4-(2-{2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetoxy}ethyl)piperazin-1-yl]propyl N(2)-benzoyl-N,N-dipropyl-alpha-glutaminate
3-(4-(2-((2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetyl)oxy)ethyl)piperazin-1-yl)propyl 4-(dipropylcarbamoyl)-4-(phenylformamido)butanoate
3-(4-(2-(2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetoxy)ethyl)piperazin-1-yl)propyl N(2)-benzoyl-N,N-dipropyl-alpha-glutaminate
3-{4-[2-({2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetyl}oxy)ethyl]piperazin-1-yl}propyl 4-(dipropylcarbamoyl)-4-(phenylformamido)butanoate
SCHEMBL27106
CHEMBL2105825
M01AB14
PTXGHCGBYMQQIG-UHFFFAOYSA-N
Tox21_113325
DB13527
CAS-57132-53-3
HY-106560
CS-0026053
NS00004776
D08427
SBI-0654187.0001
Q2208070
BRD-A19458515-001-01-2