Skip to main content

Zuclopenthixol

ADVERTISEMENT
Identification
Molecular formula
C22H25ClN2OS
CAS number
53772-83-1
IUPAC name
3-[4-[3-(2-chlorothioxanthen-9-ylidene)propyl]piperazin-1-yl]-N-methyl-propanamide
State
State

Zuclopenthixol, as a chemical compound, is generally presented in solid form at room temperature. It is utilized predominantly in its hydroxy and acetate forms for medical purposes, typically appearing as crystalline powders that are stable under standard storage conditions.

Melting point (Celsius)
123.00
Melting point (Kelvin)
396.15
Boiling point (Celsius)
502.69
Boiling point (Kelvin)
775.84
General information
Molecular weight
403.97g/mol
Molar mass
403.9830g/mol
Density
1.2681g/cm3
Appearence

Zuclopenthixol typically appears as a solid substance and is usually formulated in yellowish crystalline powder form when pure. It is often used in pharmacological preparations in the form of salts such as dihydrochloride or acetate, which may vary slightly in appearance.

Comment on solubility

Solubility Insights

The compound 3-[4-[3-(2-chlorothioxanthen-9-ylidene)propyl]piperazin-1-yl]-N-methyl-propanamide exhibits a degree of complexity in its solubility profile, which is influenced by several factors:

  • Polarity: The presence of polar functional groups, particularly the amide group, tends to enhance solubility in polar solvents like water.
  • Hydrophobic Character: On the other hand, the thioxanthene moiety adds considerable hydrophobic character, potentially limiting solubility in aqueous environments.
  • Solvent Specificity: In practice, this compound may be more soluble in organic solvents such as dichloromethane or ethanol.

When assessing solubility, it is crucial to take into account:

  1. The concentration limits of the compound in various solvents.
  2. The influence of temperature on solubility, as higher temperatures generally enhance solubility.
  3. The potential for formation of salts or other derivatives that may exhibit different solubility characteristics.

Thus, while the solubility of 3-[4-[3-(2-chlorothioxanthen-9-ylidene)propyl]piperazin-1-yl]-N-methyl-propanamide can be characterized as variable, it highlights the intricate balance between hydrophilic and hydrophobic interactions that govern its behavior in different environments.

Interesting facts

Interesting Facts About 3-[4-[3-(2-chlorothioxanthen-9-ylidene)propyl]piperazin-1-yl]-N-methyl-propanamide

This unique compound is a fascinating example of how organic chemistry can blend different molecular structures to create potentially bioactive materials. Here are some intriguing points about this compound:

  • Biodiversity of Structure: The integration of the thioxanthenone moiety suggests its potential use in medicinal chemistry, particularly for compounds targeting specific biological pathways.
  • Pharmacological Potential: The piperazine ring is often found in a variety of pharmacologically active compounds. This structure hints at the compound’s potential pharmacological properties, particularly in neuropharmacology where such piperazine derivatives are known for their anxiolytic and antipsychotic activities.
  • Halogen Substitution: The presence of the chlorine atom may significantly affect the compound's biological activity. Halogenated compounds often exhibit unique reactivity and can enhance or modulate the biological effects, making them critical in drug design.
  • Interdisciplinary Applications: This compound might find applications not only in pharmaceuticals but also in materials science as a dye or sensor material, given its organic chromophore structures.

As a chemistry student, exploring compounds like this one opens the door to numerous scientific discussions about structure-activity relationships (SAR), the influence of molecular geometry on function, and potential methods for synthesis and modification of complex organic compounds.

In conclusion, the multi-faceted nature of 3-[4-[3-(2-chlorothioxanthen-9-ylidene)propyl]piperazin-1-yl]-N-methyl-propanamide not only reflects the beauty of organic synthesis but also guides researchers towards significant breakthroughs in medicinal and material innovations.

Synonyms
Clothixamide
Clotixamide
Clotixamide [INN]
Clothixamid
4177-58-6
UNII-24623E6DZD
24623E6DZD
3-(4-(3-(2-Chlorthioxanthen-9-yliden)propyl)-1-piperazinyl)-N-methylpropionamid
4-(3-(2-Chlorothioxanthen-9-ylidene)propyl)-N-methyl-1-piperazinepropionamide
1-PIPERAZINEPROPANAMIDE, 4-(3-(2-CHLORO-9H-THIOXANTHEN-9-YLIDENE)PROPYL)-N-METHYL-
DTXSID40194593
DTXCID80117084
Clotixamida
3-[4-[(3E)-3-(2-chlorothioxanthen-9-ylidene)propyl]piperazin-1-yl]-N-methylpropanamide
3-[4-[3-(2-chlorothioxanthen-9-ylidene)propyl]piperazin-1-yl]-N-methylpropanamide
Clotixamidum
clothixamide (achiral)
CHEMBL4754653
DTXSID00863334
EAA17758
Q27253814
3-{4-[3-(2-chloro-9h-thioxanthen-9-ylidene)propyl]piperazin-1-yl}-n-methylpropanamide