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4-Methoxyphenylpiperazine

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Identification
Molecular formula
C14H22N2O
CAS number
38212-33-8
IUPAC name
3-[4-(4-methoxyphenyl)piperazin-1-yl]-N,N-dimethyl-propan-1-amine
State
State

At room temperature, 4-Methoxyphenylpiperazine is typically in a solid state, usually found as a crystalline powder or sometimes as solid crystals, which makes it easy to handle in laboratory settings.

Melting point (Celsius)
77.00
Melting point (Kelvin)
350.20
Boiling point (Celsius)
365.10
Boiling point (Kelvin)
638.30
General information
Molecular weight
248.36g/mol
Molar mass
248.3670g/mol
Density
1.0700g/cm3
Appearence

4-Methoxyphenylpiperazine appears as a white or off-white crystalline powder. It is known for its relatively pure and stable form, which is often used in research and pharmaceutical applications.

Comment on solubility

Solubility of 3-[4-(4-methoxyphenyl)piperazin-1-yl]-N,N-dimethyl-propan-1-amine

The solubility of 3-[4-(4-methoxyphenyl)piperazin-1-yl]-N,N-dimethyl-propan-1-amine in various solvents can be quite fascinating given its complex structure. This compound is characterized by its piperazine ring, which significantly influences its interactions with solvents.

Solvent Interactions

This compound exhibits differential solubility behavior in polar and non-polar solvents. Factors influencing its solubility include:

  • Polarity of the Solvent: Polar solvents may enhance solubility due to the ability to stabilize ionic and polar functional groups within the molecule.
  • Hydrogen Bonding: The presence of nitrogen atoms in the structure enables the formation of hydrogen bonds, significantly affecting solubility in hydrogen-bonding solvents.
  • Substituent Effects: The methoxy group contributes to the solubility by participating in hydrogen bonding and influencing the overall polarity of the molecule.

Expected Solubility Behavior

Based on its chemical structure, one can broadly infer:

  • Reactivity with water: Moderate solubility is expected in water due to the polar characteristics of the amine group.
  • Solubility in organic solvents: Elevated solubility may occur in organic solvents such as ethanol or methanol, owing to similar polarity and the capability for van der Waals interactions.

Overall, the solubility profile of 3-[4-(4-methoxyphenyl)piperazin-1-yl]-N,N-dimethyl-propan-1-amine is a product of intricate intermolecular forces influenced by its unique structural features. Understanding this can be crucial for its applications in pharmaceutical formulations and research.

Interesting facts

Compound Overview

The compound known as 3-[4-(4-methoxyphenyl)piperazin-1-yl]-N,N-dimethyl-propan-1-amine is a fascinating target of study in the field of medicinal chemistry. Notably, it is related to the class of compounds known as piperazines, which are recognized for their potential therapeutic applications, particularly in neurological and psychiatric disorders.

Interesting Facts

  • Therapeutic Potential: This compound exhibits potential activity as an antidepressant and anxiolytic, highlighting its significance for mental health treatments.
  • Chemical Structure: The presence of the piperazine ring in its structure is crucial for its pharmacological properties. Piperazines are often found in a variety of psychoactive drugs.
  • Role of Methoxy Group: The methoxyphenyl substituent may enhance lipophilicity, which can influence the bioactivity and permeability of the compound across biological membranes.
  • Research Applications: Compounds of this nature are often used in drug discovery processes, as they help to explore the interaction of medicinal agents with neurotransmitter systems.

Quote from the Field

As one renowned chemist put it, "The journey from compound design to therapeutic discovery is paved with the intricate dance of molecular interactions." This highlights the importance of understanding compounds like ours in the journey of drug development.

In Summary

Overall, 3-[4-(4-methoxyphenyl)piperazin-1-yl]-N,N-dimethyl-propan-1-amine stands at the intersection of organic chemistry and pharmacology, showcasing how small molecular changes can dramatically influence therapeutic effects.

Synonyms
QTU77E85XF
CL-71366 free base
UNII-QTU77E85XF
895-68-1
1-Piperazinepropanamine, 4-(4-methoxyphenyl)-N,N-dimethyl-
Piperazine, 1-(3-(dimethylamino)propyl)-4-(p-methoxyphenyl)-