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3-(4-Benzylpiperazin-1-yl)methyl-1H-indol-5-amine

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Identification
Molecular formula
C19H24N4
CAS number
NA
IUPAC name
3-[(4-benzylpiperazin-1-yl)methyl]-1H-indol-5-amine
State
State

At room temperature, this compound exists in a solid state. It is typically stable when stored under recommended conditions, shielded from light and moisture to prevent degradation.

Melting point (Celsius)
168.50
Melting point (Kelvin)
441.65
Boiling point (Celsius)
543.23
Boiling point (Kelvin)
816.38
General information
Molecular weight
335.44g/mol
Molar mass
335.4440g/mol
Density
1.2543g/cm3
Appearence

The compound is typically presented as a crystalline powder that may vary in color from white to off-white, depending on its purity and the specific synthesis method employed. The crystals are often fine and can appear somewhat fluffy, appearing insoluble in water but soluble in organic solvents.

Comment on solubility

Solubility of 3-[(4-benzylpiperazin-1-yl)methyl]-1H-indol-5-amine

The solubility of 3-[(4-benzylpiperazin-1-yl)methyl]-1H-indol-5-amine is a crucial factor to consider when assessing its utility in various applications. This compound, characterized by its complex structure, exhibits variable solubility characteristics depending on the solvent used. To better understand its solubility profile, here are some key points:

  • Polar solvents: The presence of nitrogen atoms in the piperazine group may suggest moderate solubility in polar solvents such as water and alcohols.
  • Non-polar solvents: Its indole component might render the compound less soluble in non-polar solvents such as hexane or toluene.
  • pH dependence: The solubility could be influenced by the pH of the solution, with potential ionization affecting solubility behaviors.
  • Temperature influences: As with many organic compounds, an increase in temperature often leads to enhanced solubility.

Understanding these solubility attributes is essential for applications in drug formulation and chemical reactions. In summary, the solubility of 3-[(4-benzylpiperazin-1-yl)methyl]-1H-indol-5-amine is dictated by the interactions between its molecular structure and the solvent used. Factors such as polarity, pH, and temperature play significant roles in determining its overall behavior in solution.

Interesting facts

Interesting Facts about 3-[(4-benzylpiperazin-1-yl)methyl]-1H-indol-5-amine

3-[(4-benzylpiperazin-1-yl)methyl]-1H-indol-5-amine, often referred to in the research community for its potential pharmacological applications, is a fascinating chemical compound that has captured the attention of scientists for several reasons:

  • Pharmacological Interest: This compound is explored for its possible role as a therapeutic agent. Studies suggest that it may exhibit potential activities in the treatment of various neurological disorders, influencing pathways associated with mood and cognition.
  • Structural Complexity: The compound’s unique structure features an indole moiety combined with a piperazine ring system. This combination is significant as it frequently appears in many bioactive molecules.
  • Binding Affinities: Research indicates that compounds with similar structures often show binding affinities to various neurotransmitter receptors, which may contribute to their efficacy in treating psychiatric conditions.
  • In Silico Studies: Computational chemistry has enabled researchers to predict the interaction of this compound with biological targets, suggesting modifications that could enhance its potency and selectivity.
  • Synthesis Challenges: The synthesis of this compound may pose challenges due to the intricacies involved in forming specific bonds while maintaining the stability of the indole ring, making it a compelling subject for synthetic organic chemists.

As a compound that bridges the gaps between medicinal chemistry and therapeutic development, 3-[(4-benzylpiperazin-1-yl)methyl]-1H-indol-5-amine showcases the intricate relationship between structure and biological activity, reminding us of the importance of interdisciplinary collaboration in advancing scientific knowledge.

Synonyms
3414-78-6
BRN 1594683
INDOLE, 5-AMINO-3-((4-BENZYLPIPERAZINYL)METHYL)-
3-((4-Benzylpiperazinyl)methyl)-5-indoleamine
Piperazine, 1-(5-amino-3-indolylmethyl)-4-benzyl-
DTXSID60187740
DTXCID20110231
5-23-03-00097 (beilstein handbook reference)
3-[(4-Benzyl-1-piperazinyl)methyl]-1H-indol-5-amine