Skip to main content

3-[(4-benzylpiperazin-1-yl)methyl]-5-nitro-1H-indole

ADVERTISEMENT
Identification
Molecular formula
C20H22N4O2
CAS number
600109-02-2
IUPAC name
3-[(4-benzylpiperazin-1-yl)methyl]-5-nitro-1H-indole
State
State

At room temperature, 3-[(4-benzylpiperazin-1-yl)methyl]-5-nitro-1H-indole is typically a solid.

Melting point (Celsius)
172.00
Melting point (Kelvin)
445.15
Boiling point (Celsius)
748.50
Boiling point (Kelvin)
1 021.65
General information
Molecular weight
378.43g/mol
Molar mass
378.4280g/mol
Density
1.2840g/cm3
Appearence

This compound generally appears as a crystalline solid. The color can vary, but it often manifests in shades ranging from yellow to off-white. It forms distinct crystal structures when purified.

Comment on solubility

Solubility of 3-[(4-benzylpiperazin-1-yl)methyl]-5-nitro-1H-indole

The solubility of 3-[(4-benzylpiperazin-1-yl)methyl]-5-nitro-1H-indole can be characterized by several key factors that influence its behavior in various solvents:

  • Polarity: This compound contains both polar and non-polar functional groups, which can affect its solubility in water versus organic solvents.
  • Hydrogen Bonding: The presence of nitro and amine groups suggests potential hydrogen bonding. This might enhance solubility in polar solvents.
  • Solvent Type: Typically, compounds like this one are more soluble in organic solvents such as ethanol and DMSO, rather than in water, indicating low aqueous solubility.
  • pH Influence: It's important to note that the solubility can vary significantly with pH. The ionization state of the piperazine ring can change, affecting how well the compound can dissolve in solution.

In conclusion, while 3-[(4-benzylpiperazin-1-yl)methyl]-5-nitro-1H-indole shows limited solubility in water, its solubility profile in organic solvents is more favorable. Understanding these solubility characteristics is crucial for applications involving this compound, allowing researchers to make informed decisions regarding solvent use.

Interesting facts

Interesting Facts about 3-[(4-benzylpiperazin-1-yl)methyl]-5-nitro-1H-indole

3-[(4-benzylpiperazin-1-yl)methyl]-5-nitro-1H-indole is a remarkable compound that belongs to the indole family, which is renowned for its diverse biological activities. Here are some fascinating aspects of this compound:

  • Pharmacological Potential: This compound exhibits potential pharmacological properties, particularly as a neurotransmitter modulator. Its structural similarity to various psychoactive substances raises significant interest in its effects on the central nervous system.
  • Structure-Activity Relationship: The inclusion of the benzylpiperazine moiety enhances the compound's ability to interact with specific receptors, highlighting the importance of substituents in designing effective therapeutic agents.
  • Indole Derivatives: Compounds featuring the indole structure are often associated with anti-inflammatory, analgesic, and anticancer properties. Research into this compound could reveal new therapeutic applications in these areas.
  • Research Applications: Its unique structure has made it a topic of interest in various studies that aim to examine the modulation of specific receptors, such as serotonin and dopamine receptors, potentially paving the way for new psychiatric medications.
  • Safety and Efficacy: As with any compound under investigation, understanding its safety profile and efficacy through rigorous testing is paramount. This aspect not only ensures therapeutic value but also compliance with regulatory standards.

Overall, the chemical world continues to unveil secrets through compounds like 3-[(4-benzylpiperazin-1-yl)methyl]-5-nitro-1H-indole, which showcases the interplay between chemistry and pharmacology. Each intriguing structure opens new avenues for therapeutic innovation and scientific discovery.

Synonyms
3414-72-0
INDOLE, 3-((4-BENZYLPIPERAZINYL)METHYL)-5-NITRO-
BRN 1603558
3-((4-Benzylpiperazinyl)methyl)-5-nitroindole
3-[(4-Benzyl-1-piperazinyl)methyl]-5-nitro-1H-indole
DTXSID70187736