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Chlorambucil Hydrochloride

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Identification
Molecular formula
C14H20Cl3NO2
CAS number
305-03-3
IUPAC name
3-[4-[bis(2-chloroethyl)amino]phenyl]-2-methyl-propanoic acid;hydrochloride
State
State

At room temperature, chlorambucil hydrochloride is a solid. It is commonly used in its crystalline form for pharmaceutical applications.

Melting point (Celsius)
77.00
Melting point (Kelvin)
350.15
Boiling point (Celsius)
233.00
Boiling point (Kelvin)
506.15
General information
Molecular weight
354.71g/mol
Molar mass
354.7130g/mol
Density
1.2900g/cm3
Appearence

Chlorambucil hydrochloride generally appears as a white to pale yellow crystalline powder. It is hygroscopic, meaning it can absorb moisture from the air, and is usually marketed in this stable powdered form for medicinal use.

Comment on solubility

Solubility of 3-[4-[bis(2-chloroethyl)amino]phenyl]-2-methyl-propanoic acid; hydrochloride

The solubility of 3-[4-[bis(2-chloroethyl)amino]phenyl]-2-methyl-propanoic acid; hydrochloride is primarily influenced by its ionic nature and the presence of functional groups in its structure.

As a hydrochloride salt, it typically exhibits the following solubility characteristics:

  • High Water Solubility: The introduction of the hydrochloride group usually enhances solubility in water compared to its free base form.
  • Temperature Dependency: Solubility may increase with temperature; hence, solubility studies across various temperatures could provide further insights.
  • pH Influence: Being an acid, its solubility can also be affected by the pH of the solution, often exhibiting improved solubility in more acidic conditions.

To summarize, this compound's solubility is expected to be favorable in aqueous solutions, particularly under controlled conditions. The specific nature of hydrochloride salts generally leads to a trend of enhanced solubility, making it relevant in various chemical and pharmaceutical applications.

Interesting facts

Interesting Facts About 3-[4-[bis(2-chloroethyl)amino]phenyl]-2-methyl-propanoic acid; hydrochloride

This compound, commonly known within certain scientific contexts, is particularly noteworthy due to its complex structure and functional applications in medicinal chemistry. Here are several engaging insights:

  • Historical Context: The compound is part of a class of chemistry that has been studied for decades, particularly in the development of anti-cancer therapeutics. Chirality and functional group orientation play crucial roles in its biological activity.
  • Mechanism of Action: It functions primarily as an alkylating agent, meaning it can bind to nucleophilic sites in DNA. This provides insights into its potential use as a chemotherapeutic agent.
  • Therapeutic Potential: The bis(2-chloroethyl)amino group presents a unique interaction with cellular targets, making it interesting for research focused on targeted cancer therapies.
  • Research Applications: Scientists are continuously exploring modifications of this compound to enhance its efficacy and reduce side effects, placing it at the forefront of pharmaceutical research.
  • Interdisciplinary Connections: Its study bridges multiple fields such as organic chemistry, pharmacology, and molecular biology, making it a great topic for students interested in the intersections of science.

Overall, 3-[4-[bis(2-chloroethyl)amino]phenyl]-2-methyl-propanoic acid; hydrochloride not only embodies the intricacies of chemical synthesis but also exemplifies the ongoing quest for effective treatments in biomedical research. As you explore the potential of this compound, consider the broader implications it holds for advancements in health and medicine.

Synonyms
beta-p-N-Di(beta-chloroethyl)aminophenylbutyric acid hydrochloride
3276-05-9
p-(Bis(2-chloroethyl)amino)-beta-methylhydrocinnamic acid hydrochloride
Benzenepropanoic acid, 4-(bis(2-chloroethyl)amino)-beta-methyl-, hydrochloride
HYDROCINNAMIC ACID, p-(BIS(2-CHLOROETHYL)AMINO)-beta-METHYL-, HYDROCHLORIDE
DTXSID80954411
3-{4-[Bis(2-chloroethyl)amino]phenyl}-2-methylpropanoic acid--hydrogen chloride (1/1)