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Ebastine

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Identification
Molecular formula
C32H39Cl2N3O
CAS number
90729-43-4
IUPAC name
3-[(4-chloro-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-5-ium-11-yl)oxy]propyl-dimethyl-ammonium;dichloride
State
State

At room temperature, ebastine exists as a solid.

Melting point (Celsius)
76.50
Melting point (Kelvin)
349.70
Boiling point (Celsius)
336.50
Boiling point (Kelvin)
609.60
General information
Molecular weight
471.37g/mol
Molar mass
471.3670g/mol
Density
0.9860g/cm3
Appearence

Ebastine appears as a white to off-white crystalline powder, generally odorless. It is known for its high solubility in organic solvents while being sparingly soluble in water.

Comment on solubility

Solubility of 3-[(4-chloro-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-5-ium-11-yl)oxy]propyl-dimethyl-ammonium; dichloride

The compound 3-[(4-chloro-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-5-ium-11-yl)oxy]propyl-dimethyl-ammonium; dichloride displays unique solubility characteristics that are influenced by its complex structure. Here are some key points regarding its solubility:

  • Polar Nature: The presence of the ammonium group imparts a polar character to the compound, which generally enhances solubility in polar solvents such as water.
  • Ionization: As a quaternary ammonium salt due to the dichloride component, it is more likely to ionize in solution, contributing to increased solubility.
  • Hydrophobic Interactions: The cyclohepta[b]quinoline moiety introduces hydrophobic segments, which may affect its solubility in non-polar solvents.

Overall, one could predict that this compound should have considerable solubility in polar solvents, particularly due to the cationic nature from the ammonium ion, while exhibiting limited solubility in non-polar solvents. Understanding these solubility dynamics is crucial for effective applications and formulations involving this compound.

Interesting facts

Interesting Facts about 3-[(4-chloro-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-5-ium-11-yl)oxy]propyl-dimethyl-ammonium; dichloride

This compound, a member of the quaternary ammonium compounds, showcases a fascinating interface between organic and medicinal chemistry. Here are some notable aspects to consider:

  • Structure and Function: The compound features a quaternary ammonium group, which is known for its antimicrobial properties. Its unique structure derived from cycloheptaquinoline contributes to its biological activity.
  • Pharmacological Potential: Compounds like this one are often investigated for their potential uses in treating various ailments. The specific structure may interact with biological targets, making it a candidate for drug development.
  • Chlorine’s Role: The presence of chlorine, specifically in the 4-position, is crucial. Chlorinated compounds frequently exhibit improved potency and selectivity in biological systems.
  • Versatility of Quaternary Ammoniums: Beyond medicinal use, quaternary ammonium compounds are also used as surfactants, preservatives, and in various industrial applications, showcasing their versatility.

As we delve deeper into the studies surrounding this compound, researchers continuously uncover its potential applications. This intricate blend of chemistry and biology exemplifies the remarkable prospects present in organic compounds. As one researcher aptly put it, "The more we understand the intricacies of these compounds, the closer we get to addressing significant health challenges."

Synonyms
5546-63-4
6H-Cyclohepta(b)quinoline, 4-chloro-11-(3-(dimethylamino)propoxy)-7,8,9,10-tetrahydro-, dihydrochloride
4-Chloro-11-(3-(dimethylamino)propoxy)-7,8,9,10-tetrahydro-6H-cyclohepta(b)quinoline 2HCl