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Clonidine

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Identification
Molecular formula
C9H8ClN5
CAS number
61-64-3
IUPAC name
3-(4-chlorophenyl)-1-(1H-imidazol-2-ylmethyl)-2,3,4,5-tetrahydro-1-benzazepine
State
State

At room temperature, clonidine is in a solid state, specifically in the form of a crystalline powder.

Melting point (Celsius)
157.00
Melting point (Kelvin)
430.15
Boiling point (Celsius)
315.00
Boiling point (Kelvin)
588.15
General information
Molecular weight
230.08g/mol
Molar mass
230.0810g/mol
Density
0.9202g/cm3
Appearence

Clonidine appears as a white to off-white crystalline powder. It is generally odorless but may sometimes have a faint characteristic odor depending on the manufacturing process. It is soluble in water and organic solvents such as ethanol and methanol, which makes it useful in pharmaceutical preparations.

Comment on solubility

Solubility of 3-(4-chlorophenyl)-1-(1H-imidazol-2-ylmethyl)-2,3,4,5-tetrahydro-1-benzazepine

The solubility of 3-(4-chlorophenyl)-1-(1H-imidazol-2-ylmethyl)-2,3,4,5-tetrahydro-1-benzazepine can be quite complex due to its unique molecular structure and functional groups. Here are some key points to consider:

  • Polarity: The presence of the imidazole moiety suggests that this compound may exhibit moderate polarity, which can influence its solubility in various solvents.
  • Solvent Compatibility: It is essential to analyze its solubility in:
    • Polar solvents: Likely to include water and alcohols, which may dissolve parts of the molecule.
    • Non-polar solvents: Compounds like hexane or toluene may exhibit lesser solubility due to the overall polar character of the structure.
  • Temperature Impact: Generally, an increase in temperature can enhance solubility for many organic compounds. This compound may follow that trend.
  • pH Influence: If the compound comprises ionizable functional groups, the pH of the solvent can significantly affect its solubility.

In conclusion, the solubility behavior of this compound is anticipated to be influenced by a combination of its structural characteristics, the nature of the solvent, and external conditions such as temperature and pH. Understanding these factors is crucial for applications in chemical formulations or biological systems.

Interesting facts

Interesting Facts about 3-(4-chlorophenyl)-1-(1H-imidazol-2-ylmethyl)-2,3,4,5-tetrahydro-1-benzazepine

This compound, often used in medicinal chemistry, is a fascinating example of complex organic structure designed to exhibit specific biological activities. Here are a few intriguing aspects of this compound:

  • Diverse Applications: Due to its imidazole and benzazepine components, this compound may play a significant role in drug development, particularly in the treatment of neurological disorders.
  • Molecular Complexity: The structure features fused ring systems, which adds to its chemical stability and influences its interaction with biological targets.
  • Chlorine Substituent: The presence of a 4-chlorophenyl group can enhance the lipophilicity of the compound, potentially improving its ability to cross biological membranes.
  • Binding Affinity: Compounds like this one are often optimized for binding to specific receptors in the nervous system, which can facilitate therapeutic effects while minimizing side effects.

As you study this compound, consider the following quote:

“The beauty of chemistry lies in its ability to create complexity from simplicity.”

In conclusion, 3-(4-chlorophenyl)-1-(1H-imidazol-2-ylmethyl)-2,3,4,5-tetrahydro-1-benzazepine represents a rich area of study, reflecting how small changes in molecular structure can lead to significant variations in biological function and therapeutic potential. Understanding such compounds is crucial for advancements in pharmacology and medicinal applications.

Synonyms
3-(4-chlorophenyl)-1-(1H-imidazol-2-ylmethyl)-2,3,4,5-tetrahydro-1-benzazepine
DTXSID90274617