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Loratadine

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Identification
Molecular formula
C22H23ClN2O
CAS number
79794-75-5
IUPAC name
3-(4-chlorophenyl)-1-[4-(2-hydroxypropyl)piperazin-1-yl]-3-phenyl-propan-1-one
State
State

At room temperature, Loratadine is in a solid state.

Melting point (Celsius)
134.00
Melting point (Kelvin)
407.15
Boiling point (Celsius)
605.15
Boiling point (Kelvin)
878.30
General information
Molecular weight
382.89g/mol
Molar mass
382.8850g/mol
Density
1.2680g/cm3
Appearence

Loratadine is a white to off-white crystalline powder. It is practically insoluble in water and slightly soluble in acetone, alcohol, and chloroform.

Comment on solubility

Solubility of 3-(4-chlorophenyl)-1-[4-(2-hydroxypropyl)piperazin-1-yl]-3-phenyl-propan-1-one

The solubility of 3-(4-chlorophenyl)-1-[4-(2-hydroxypropyl)piperazin-1-yl]-3-phenyl-propan-1-one can be influenced by several factors due to its complex structure. Key aspects to consider include:

  • Polarity: The presence of the hydroxyl group enhances polarity, potentially increasing solubility in polar solvents such as water.
  • Hydrophobic regions: The numerous aromatic rings contribute hydrophobic characteristics, which may limit solubility in water but increase compatibility with organic solvents.
  • Temperature effect: Solubility often increases with temperature; thus, elevated temperatures might enhance the dissolution of this compound.
  • pH influence: Variations in pH can alter the ionization state of the compound, affecting its solubility profile, particularly in aqueous solutions.

In summary, while 3-(4-chlorophenyl)-1-[4-(2-hydroxypropyl)piperazin-1-yl]-3-phenyl-propan-1-one displays features that may allow for solubility in specific solvents, the overall potential for solubility is a balance of its polar and nonpolar characteristics. Solubility tests in various environments are essential for determining its practical applications.

Interesting facts

Interesting Facts About 3-(4-Chlorophenyl)-1-[4-(2-Hydroxypropyl)piperazin-1-yl]-3-phenyl-propan-1-one

This compound, known for its complexity and intriguing structure, is a member of the propan-1-one family. Its design cleverly integrates multiple functional groups, rendering it a subject of interest in various fields of chemistry. Here are some key highlights about this fascinating compound:

  • Pharmacological Significance: This compound has been studied for its potential therapeutic effects, particularly in the realm of mental health, highlighting its utility in medicinal chemistry.
  • Structure Activity Relationship (SAR): The unique combination of a piperazine ring and a phenyl group contributes to its biological activity, providing insights into how different structural modifications can impact the efficacy of similar compounds.
  • Chlorinated Aromatics: The presence of a chlorophenyl moiety suggests interesting implications in reactivity and solubility, a common aspect of chlorinated compounds that can affect interactions with biological targets.
  • Hydroxypropyl Modification: The hydroxypropyl group can enhance solubility and biological activity, making this compound a subject of study for drug formulation and delivery systems.

As we delve deeper into its synthesis, reactivity, and biological applications, it becomes clear this compound offers a well-rounded example of how chemical modifications can lead to significant variations in properties and activities. Such compounds are a testament to the intricate design of nature at the molecular level, often leading to breakthroughs in pharmacology and therapeutic practices.

In summary, the multifaceted nature of 3-(4-Chlorophenyl)-1-[4-(2-Hydroxypropyl)piperazin-1-yl]-3-phenyl-propan-1-one serves as an excellent case study within the chemical community. Its exploration can yield valuable insights into drug development and the evolution of novel therapies.

Synonyms
beta-(p-Chlorophenyl)phenethyl 4-(2-hydroxypropyl)piperazinyl ketone
23902-87-6
1-(3-(p-Chlorophenyl)-3-phenylpropionyl)-4-(2-hydroxypropyl)piperazine
KETONE, beta-(p-CHLOROPHENYL)PHENETHYL 4-(2-HYDROXYPROPYL)PIPERAZINYL
Piperazine, 1-(3-(p-chlorophenyl)-3-phenylpropionyl)-4-(2-hydroxypropyl)-
RefChem:350442
3-(4-chlorophenyl)-1-[4-(2-hydroxypropyl)piperazin-1-yl]-3-phenylpropan-1-one
DTXSID60946697