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Nefazodone

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Identification
Molecular formula
C25H32ClN3O2
CAS number
83366-66-9
IUPAC name
3-(4-chlorophenyl)-1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-phenyl-propan-1-one
State
State

At room temperature, Nefazodone is typically a solid substance.

Melting point (Celsius)
183.00
Melting point (Kelvin)
456.15
Boiling point (Celsius)
543.90
Boiling point (Kelvin)
817.05
General information
Molecular weight
470.01g/mol
Molar mass
470.9620g/mol
Density
1.2870g/cm3
Appearence

Nefazodone is typically found in its hydrochloride salt form as a white to off-white crystalline powder.

Comment on solubility

Solubility Overview

The solubility of the compound 3-(4-chlorophenyl)-1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-phenyl-propan-1-one is influenced by various factors, making it a noteworthy subject for study. Generally speaking, this compound is expected to exhibit varying solubility in different solvents:

  • Polar solvents: Due to the presence of the piperazine moiety, it may show enhanced solubility in polar solvents like water or methanol, although its overall structure leans towards being hydrophobic.
  • Non-polar solvents: The aromatic rings (4-chlorophenyl and 2-methoxyphenyl) contribute to a greater solubility in non-polar solvents such as hexane or chloroform.
  • Characteristic behavior: Compounds like this one, which have both hydrophobic and hydrophilic components, often manifest a unique behavior where solubility can be **significantly affected** by pH and other environmental factors.

Researchers often note that “the solubility characteristics of a compound can be a determining factor in its bioavailability and pharmacological efficacy.” Therefore, it's essential to conduct precise experiments under controlled conditions to ascertain the solubility profile comprehensively.

In summary, the solubility of this compound is complex, characterized by both polar and non-polar interactions, necessitating a more in-depth exploration to fully understand its behavior in various environments.

Interesting facts

Interesting Facts About 3-(4-chlorophenyl)-1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-phenyl-propan-1-one

This complex compound is a member of the phenyl-propanone family and showcases unique structural features that make it a subject of interest in medicinal chemistry. Here are some compelling facts:

  • Structural Diversity: The compound exhibits a multifaceted structure with various ring systems, including a piperazine moiety and aromatic rings, which can enhance its biological activity through multiple interaction sites.
  • Biological Relevance: Compounds like this one are often explored for their pharmacological properties. Specifically, they may possess potential **antidepressant** or **anxiolytic** effects, which makes them a target for research in psychopharmacology.
  • Synthesis and Reactions: The creation of such compounds typically involves various organic synthetic techniques, including nucleophilic substitutions and coupling reactions, showcasing the ingenuity required in organic synthesis.
  • Pharmacophore Insights: Understanding the pharmacophore, which denotes the essential features responsible for its biological activity, may guide the development of even more potent derivatives of this compound.
  • Research Potential: Given the increasing interest in polyfunctional compounds, this compound could be a promising candidate for further studies aimed at elucidating its mechanism of action and overall safety profile in therapeutic applications.

As a student or researcher delving into the world of chemical compounds, exploring the nuances of such intricate molecules can be both challenging and rewarding. As the famous chemist Linus Pauling once stated, "The best way to have a good idea is to have plenty of ideas." Engaging with stimulating compounds like this one can certainly inspire innovative thoughts and breakthroughs in the field of medicinal chemistry.

Synonyms
23902-91-2
beta-(p-Chlorophenyl)phenethyl 4-(o-methoxyphenyl)piperazinyl ketone
1-(3-(p-Chlorophenyl)-3-phenylpropionyl)-4-(o-methoxyphenyl)piperazine
KETONE, beta-(p-CHLOROPHENYL)PHENETHYL 4-(o-METHOXYPHENYL)PIPERAZINYL
Piperazine, 1-(3-(p-chlorophenyl)-3-phenylpropionyl)-4-(o-methoxyphenyl)-
RefChem:350449
3-(4-chlorophenyl)-1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-phenylpropan-1-one
DTXSID90946701