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Lorpiprazole

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Identification
Molecular formula
C27H29ClN2O
CAS number
61167-48-6
IUPAC name
3-(4-chlorophenyl)-1-[4-(m-tolylmethyl)piperazin-1-yl]-3-phenyl-propan-1-one
State
State

Solid at room temperature. The compound is stable under normal conditions of use and storage.

Melting point (Celsius)
85.00
Melting point (Kelvin)
358.15
Boiling point (Celsius)
545.20
Boiling point (Kelvin)
818.35
General information
Molecular weight
421.97g/mol
Molar mass
421.9660g/mol
Density
1.2000g/cm3
Appearence

Lorpiprazole appears as an off-white to pale yellow crystalline powder. It may sometimes appear as a solid with a slightly waxy texture. The compound is typically odorless.

Comment on solubility

Solubility Characteristics of 3-(4-chlorophenyl)-1-[4-(m-tolylmethyl)piperazin-1-yl]-3-phenyl-propan-1-one

The solubility of 3-(4-chlorophenyl)-1-[4-(m-tolylmethyl)piperazin-1-yl]-3-phenyl-propan-1-one can be assessed from the perspectives of polarity, molecular structure, and intermolecular interactions. This compound, which contains a complex organic structure, showcases interesting solubility features that are influenced by its functional groups.

Key Factors Influencing Solubility:

  • Polarity: The presence of halogen atoms, such as chlorine, may enhance polar characteristics, potentially leading to increased solubility in polar solvents.
  • Molecular Structure: The bulky groups, including the piperazine moiety and aromatic rings, could hinder solvation, reducing solubility in certain solvents.
  • Functional Groups: The presence of the ketone group may facilitate hydrogen bonding, affecting interactions with solvents.

It is essential to consider the following when evaluating the solubility:

  1. In general, compounds that are more non-polar tend to be less soluble in polar solvents (like water) but more soluble in non-polar solvents (like hexane).
  2. Conversely, polar compounds can often dissolve in water or other polar solvents due to hydrophilic interactions.
  3. Ultimately, the solubility of this compound may necessitate experimentation under varying conditions to establish specific solvent compatibility.

In conclusion, the solubility of 3-(4-chlorophenyl)-1-[4-(m-tolylmethyl)piperazin-1-yl]-3-phenyl-propan-1-one is subject to a multitude of factors that must be explored to fully understand its behavior in different solvents.

Interesting facts

Exploring 3-(4-chlorophenyl)-1-[4-(m-tolylmethyl)piperazin-1-yl]-3-phenyl-propan-1-one

This intriguing compound has garnered attention in the field of medicinal chemistry due to its potential therapeutic applications. Notably, it features a complex structure that allows for various interactions within biological systems. Here are some fascinating elements to consider:

  • Diverse Structural Features: The presence of a piperazine ring combined with a phenyl group illustrates the compound's intricate chemical architecture, which is essential for modulating its pharmacological activity.
  • Potential Pharmacological Effects: Research suggests that compounds of this nature may exhibit properties that could be useful in treating neurological disorders, potentially acting as anxiolytics or antidepressants.
  • Chirality Considerations: Chirality plays a significant role in the behavior of this compound, leading to variations in efficacy and safety depending on the specific enantiomer employed in therapeutic applications.
  • Research Interest: The unique combination of a chlorophenyl moiety and a m-tolylmethyl substituent has piqued the interest of chemists seeking to develop novel compounds that may improve upon existing treatments or offer new mechanisms of action.

To quote a famous chemist, "The beauty of chemistry lies in the details of molecular interactions," and this compound serves as a prime example of such beauty, where understanding its structure could unlock new potentials in pharmaceutical innovation.

As research continues, this compound may pave the way for advancements in medical science, bolstering the importance of studying complex organic molecules in the pursuit of healthcare solutions.

Synonyms
beta-(p-Chlorophenyl)phenethyl 4-(m-methylbenzyl)piperazinyl ketone
23917-55-7
1-(3-(p-Chlorophenyl)-3-phenylpropionyl)-4-(m-methylbenzyl)piperazine
KETONE, beta-(p-CHLOROPHENYL)PHENETHYL 4-(m-METHYLBENZYL)PIPERAZINYL
Piperazine, 1-(3-(p-chlorophenyl)-3-phenylpropionyl)-4-(m-methylbenzyl)-
RefChem:350446
DTXSID00946737
3-(4-Chlorophenyl)-1-{4-[(3-methylphenyl)methyl]piperazin-1-yl}-3-phenylpropan-1-one