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Clomiphene

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Identification
Molecular formula
C26H28ClNO
CAS number
911-45-5
IUPAC name
3-(4-chlorophenyl)-2-phenyl-prop-2-enenitrile
State
State

At room temperature, Clomiphene is a solid.

Melting point (Celsius)
116.50
Melting point (Kelvin)
389.65
Boiling point (Celsius)
491.50
Boiling point (Kelvin)
764.65
General information
Molecular weight
405.97g/mol
Molar mass
405.9660g/mol
Density
1.1520g/cm3
Appearence

Clomiphene appears as a white to pale yellow, crystalline powder. It is practically insoluble in water, sparingly soluble in alcohol, and freely soluble in chloroform.

Comment on solubility

Solubility of 3-(4-chlorophenyl)-2-phenyl-prop-2-enenitrile

The solubility of 3-(4-chlorophenyl)-2-phenyl-prop-2-enenitrile in various solvents is an interesting aspect worth exploring. This compound, which has a complex structure, exhibits distinct solubility characteristics depending on the nature of the solvent.

Factors Influencing Solubility

Several factors can affect the solubility of this compound:

  • Polarity of the Solvent: As a rule of thumb, "like dissolves like." Polar solvents may not effectively solubilize non-polar compounds.
  • Temperature: Increasing temperatures often enhance solubility, allowing greater dissolution of the compound in solvents.
  • Molecular Interactions: Hydrogen bonding, van der Waals forces, and other intermolecular interactions can also influence how well this compound dissolves.

Typical Solubility Behaviors

For 3-(4-chlorophenyl)-2-phenyl-prop-2-enenitrile, solubility can typically be observed in:

  • Organic Solvents: Such as ethanol, dichloromethane, and acetone, where the compound tends to dissolve better due to similar non-polar characteristics.
  • Limited Water Solubility: This compound is expected to have very low solubility in water due to its hydrophobic nature.

In summary, understanding the solubility of 3-(4-chlorophenyl)-2-phenyl-prop-2-enenitrile is crucial for its practical applications, be it in reactions or formulations. Proper solvent selection can significantly influence its effectiveness in various chemical processes.

Interesting facts

Interesting Facts about 3-(4-chlorophenyl)-2-phenyl-prop-2-enenitrile

3-(4-chlorophenyl)-2-phenyl-prop-2-enenitrile is a fascinating compound belonging to the family of α,β-unsaturated nitriles. Below are some intriguing facts about this compound:

  • Structural Highlights: This compound features a unique structure that includes a prop-2-enenitrile backbone, characterized by its double bond and the presence of a cyano group (-C≡N). The presence of both a chlorophenyl and a phenyl group contributes to its distinct chemical properties.
  • Potential Applications: Compounds with a similar structure often exhibit significant biological activity. Research indicates that derivatives of this compound may have potential applications in pharmaceuticals, particularly in the development of anti-cancer agents.
  • Reaction Versatility: The unsaturation in the structure makes it an excellent candidate for further chemical reactions, such as Michael additions and Nucleophilic additions, allowing for the synthesis of a diverse array of derivatives.
  • Electrophilic Aromatic Substitution: The presence of the chlorophenyl group can serve as a directing group in electrophilic aromatic substitution reactions, potentially influencing the reactivity and selectivity in synthetic routes.
  • Environmental Considerations: As with many compounds incorporating halogens, studying the environmental impact and degradation pathways of 3-(4-chlorophenyl)-2-phenyl-prop-2-enenitrile is critical. Compounds like these are often scrutinized for their stability and persistence in various ecosystems.

In summary, 3-(4-chlorophenyl)-2-phenyl-prop-2-enenitrile is not just a simple chemical entity; its complex structure and potential utility in various fields make it a subject of ongoing research and interest in the world of chemistry. As scientists continue to explore the implications of such compounds, the insights gained can lead to numerous innovative applications and advancements.

Synonyms
3-(4-chlorophenyl)-2-phenylprop-2-enenitrile
(2E)-3-(4-chlorophenyl)-2-phenylacrylonitrile
Maybridge4_002847
DTXSID901236110
AKOS030751224
DB-080960
I+/--[(4-Chlorophenyl)methylene]benzeneacetonitrile
(2Z)-3-(4-chlorophenyl)-2-phenylprop-2-enenitrile